AB181494

Anti-MEF2A antibody [2F9H2]

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(3 제품이 사용된 논문 )

Mouse Monoclonal MEF2A antibody. Suitable for WB and reacts with Recombinant fragment - Human, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MEF2A aa 350-500.

대체 명칭 보기

MEF2, MEF2A, Myocyte-specific enhancer factor 2A, Serum response factor-like protein 1

2 이미지

Supplier Data

Western blot - Anti-MEF2A antibody [2F9H2] (AB181494)

Expected MWt is 38 kDa.

All lanes:

Western blot - Anti-MEF2A antibody [2F9H2] (ab181494) at 1/500 dilution

All lanes:

MEF2A (AA: 391-497) recombinant protein

Predicted band size: 55 kDa

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Supplier Data

Western blot - Anti-MEF2A antibody [2F9H2] (AB181494)

All lanes:

Western blot - Anti-MEF2A antibody [2F9H2] (ab181494) at 1/500 dilution

Lane 1:

HEK293 cell lysate

Lane 2:

MEF2A (AA: 391-497)-hIgGFc transfected HEK293 cell lysate

Predicted band size: 55 kDa

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주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

2F9H2

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Recombinant Fragment Protein within Human MEF2A aa 350-500. The exact immunogen used to generate this antibody is proprietary information.

Q02078

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대체품

Primary Antibodies

AB227120

Anti-MEF2A antibody - C-terminal

Immunocytochemistry/ Immunofluorescence - Anti-MEF2A antibody - C-terminal (AB227120)

Primary Antibodies

AB30644

Anti-MEF2A (phospho T312) antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEF2A (phospho T312) antibody (AB30644)

Primary Antibodies

AB264329

Anti-MEF2A antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEF2A antibody (AB264329)

Primary Antibodies

AB76063

Anti-MEF2A antibody [EP1706Y]

RabMAb|Recombinant|20ul selling size

Flow Cytometry (Intracellular) - Anti-MEF2A antibody [EP1706Y] (AB76063)

Primary Antibodies

AB109420

Anti-MEF2A antibody [EPR1451]

RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-MEF2A antibody [EPR1451] (AB109420)

Primary Antibodies

AB235999

Anti-MEF2A antibody [EP1706Y] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-MEF2A antibody [EP1706Y] - BSA and Azide free (AB235999)

Primary Antibodies

AB51151

Anti-MEF2A (phospho S408) antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEF2A (phospho S408) antibody (AB51151)

보완 제품

Assay Kits

AB314602

Human MEF2A ELISA Kit

SimpleStep

Sandwich ELISA - Human MEF2A ELISA Kit (AB314602)

Primary Antibodies

AB211493

Anti-MEF2C antibody [EPR19089-202] - ChIP Grade

RabMAb|KO Validated|Recombinant|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-MEF2C antibody [EPR19089-202] - ChIP Grade (AB211493)

Primary Antibodies

AB32537

Anti-ERK1 antibody [Y72]

Flow Cytometry (Intracellular) - Anti-ERK1 antibody [Y72] (AB32537)

Primary Antibodies

AB183734

Anti-GFP antibody [EPR14104]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFP antibody [EPR14104] (AB183734)

Primary Antibodies

AB124800

Anti-Myogenin antibody [EPR4789]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myogenin antibody [EPR4789] (AB124800)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Recombinant fragment - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

Purification 관련 사항

Purified from tissue culture supernatant.

보관 버퍼

Preservative: 0.05% Sodium azide Constituents: PBS

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

MEF2A or Myocyte Enhancer Factor 2A is a transcription factor involved in regulating gene expression. MEF2A is approximately 55 kDa in size and is expressed in a variety of tissues including muscle brain and heart. It is part of the MEF2 family of transcription factors which all share a similar MADS-box/MEF2 domain structure. MEF2A binds to DNA and influences the transcription of genes involved in muscle differentiation and development.

Biological function summary

MEF2A participates in transcriptional regulation as part of a larger complex that includes other regulatory proteins. This transcription factor plays an essential role in the development and function of muscles. It activates the transcription of genes necessary for muscle fiber formation and adaptation. MEF2A also influences the expression of genes related to neuronal survival and plasticity impacting cognitive function and memory in the brain.

Pathways

MEF2A is involved in both the MAPK/ERK and PI3K/Akt pathways which are significant for cellular growth survival and differentiation. MEF2A interacts with proteins like MAPK and PI3K impacting these signaling pathways that regulate cell proliferation and apoptosis. This interaction highlights its role in cellular response to external stimuli and stress signals positioning MEF2A as an important factor in cell fate decisions.

Mutations or dysregulation of MEF2A are connected to cardiovascular diseases particularly coronary artery disease. MEF2A mutations can disrupt normal transcriptional regulation leading to impaired cardiovascular function. Additionally alterations in MEF2A function are linked to neurodegenerative disorders such as Alzheimer's disease where it may interact with proteins including Tau and amyloid precursor protein influencing neuronal health and survival.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.

See full target information MEF2A

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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Scientific reports 15:17364 PubMed40389489

2025

Inhibitory effects of high extracellular L-glutamate concentrations on skeletal myogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Himiko Ban,Koji Nobe,Soushi Kobayashi

Amino acids 51:1657-1666 PubMed31729551

2019

Methionine restriction at the post-weanling period promotes muscle fiber transition in piglets and improves intramuscular fat content in growing-finishing pigs.

Applications

Unspecified application

Species

Unspecified reactive species

Li Wu,Haiwen Zhang,Lin Na,Xihong Zhou,Xiang Li,Yurong Zhao,Zhen Wen,Qinghua He

Endocrinology 156:1303-15 PubMed25646713

2015

Brain innate immunity regulates hypothalamic arcuate neuronal activity and feeding behavior.

Applications

Unspecified application

Species

Unspecified reactive species

Wagner L Reis,Chun-Xia Yi,Yuanqing Gao,Mathias H Tschöp,Javier E Stern

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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