AB244267

Anti-MEIS2 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal MEIS2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MEIS2 aa 150-300.

대체 명칭 보기

MRG1, MEIS2, Homeobox protein Meis2, Meis1-related protein 1

5 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEIS2 antibody (AB244267)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEIS2 antibody (AB244267)

Formalin-fixed, paraffin-embedded human prostate tissue stained for MEIS2 using ab244267 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEIS2 antibody (AB244267)

Formalin-fixed, paraffin-embedded human endometrium tissue stained for MEIS2 using ab244267 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEIS2 antibody (AB244267)

Formalin-fixed, paraffin-embedded human cerebral cortex tissue stained for MEIS2 using ab244267 at 1/500 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-MEIS2 antibody (AB244267)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-MEIS2 antibody (AB244267)

PFA-fixed, Triton X-100 permeabilized A431 (human epidermoid carcinoma cell line) cells stained for MEIS2 (green) using ab244267 at 4 μg/ml in ICC/IF.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEIS2 antibody (AB244267)

Formalin-fixed, paraffin-embedded human liver tissue stained for MEIS2 using ab244267 at 1/500 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MEIS2 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.

O14770

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

MEIS2 or Myeloid Ecotropic Viral Integration Site 2 is a transcription factor known for its role in gene regulation. This protein weighs approximately 52-54 kDa and participates in DNA binding. MEIS2 is highly expressed in tissues like the brain heart and kidneys especially during developmental stages. MEIS2 functions through direct interaction with genomic regions to regulate the transcription of target genes.

Biological function summary

MEIS2 influences cell differentiation and organ development. It interacts with other proteins as part of a complex including the HOX and PBX families to fine-tune transcriptional outcomes. MEIS2 plays a role in neuronal development where its activity helps shape the neural tissue architecture. Researchers observe that MEIS2 affects cellular processes important for forming correctly structured organs.

Pathways

MEIS2 is engaged in the retinoic acid signaling pathway and the Notch signaling pathway. These pathways are vital in embryonic development and cellular differentiation. MEIS2's interaction with the PBX1 protein demonstrates its importance in pathways that lead to precise gene expression during development. Together they contribute to regulating the transcriptional networks involved in developmental processes.

MEIS2 has links to certain developmental disorders and cancers. Mutations or aberrant expression of MEIS2 correlate with conditions like cleft palate and neuroblastoma. Notably its interaction with the HOXA9 protein has been documented in certain types of leukemia showing how MEIS2-related pathways can contribute to abnormal cell proliferation. Understanding these interactions aids research into potential targets for therapeutic intervention.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1 : PBX1b : MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription.

See full target information MEIS2

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

eLife 13: PubMed39679919

2024

Identification of an early subset of cerebellar nuclei neurons in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Maryam Rahimi-Balaei,Shayan Amiri,Thomas Lamonerie,Sih-Rong Wu,Huda Y Zoghbi,G Giacomo Consalez,Daniel Goldowitz,Hassan Marzban

Frontiers in cell and developmental biology 9:662763 PubMed34485271

2021

NLGN3 Upregulates Expression of ADAM10 to Promote the Cleavage of NLGN3 Activating the LYN Pathway in Human Gliomas.

Applications

Unspecified application

Species

Unspecified reactive species

Ning-Ning Dang,Xiao-Bing Li,Mei Zhang,Chen Han,Xiao-Yong Fan,Shu-Hong Huang

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-MEIS2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEIS2 antibody (AB244267)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEIS2 antibody (AB244267)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEIS2 antibody (AB244267)

Immunocytochemistry/ Immunofluorescence - Anti-MEIS2 antibody (AB244267)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEIS2 antibody (AB244267)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (2)

Product promise