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AB238762

Anti-MGAT2 antibody

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(1 출판물)

Rabbit Polyclonal MGAT2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MOGAT2 aa 100-300.

대체 명칭 보기

DC5, DGAT2L5, MOGAT2, 2-acylglycerol O-acyltransferase 2, Acyl-CoA:monoacylglycerol acyltransferase 2, Diacylglycerol O-acyltransferase candidate 5, Diacylglycerol acyltransferase 2-like protein 5, Monoacylglycerol O-acyltransferase 2, MGAT2, hMGAT2, hDC5

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MGAT2 antibody (AB238762)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MGAT2 antibody (AB238762)

Paraffin-embedded human small intestine tissue stained for MGAT2 using ab238762 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MOGAT2 aa 100-300. The exact immunogen used to generate this antibody is proprietary information.

Q3SYC2

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대체품

Primary Antibodies

AB228950

Anti-MGAT2 antibody

Western blot - Anti-MGAT2 antibody (AB228950)

  • 0
  • 0

보완 제품

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB307162

Anti-Monoacylglycerol Lipase/MGL antibody [EPR26936-12]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry - Anti-Monoacylglycerol Lipase/MGL antibody [EPR26936-12] (AB307162)

  • 0
  • 0
Primary Antibodies

AB217360

Anti-LIPC antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LIPC antibody (AB217360)

  • 4
  • 1
Primary Antibodies

AB134131

Anti-CD41 antibody [EPR4330]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-CD41 antibody [EPR4330] (AB134131)

  • 2
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity greater than 95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

MGAT2 also known as alpha-16-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase is an enzyme with a molecular mass of approximately 58 kDa. It plays an important role in the glycosylation process. We find MGAT2 mainly expressed in the Golgi apparatus within various human tissues. This enzyme catalyzes the addition of N-acetylglucosamine to form branched N-glycans which are essential for protein maturation and function.
Biological function summary

MGAT2 participates in the modification of N-linked oligosaccharides as part of a larger glycosylation complex. Glycosylation is a critical step in the maturation of glycoproteins impacting cell signaling protein folding and stability. MGAT2 modifies high mannose-type oligosaccharides into complex types enhancing their functional diversity. The role of MGAT2 in these processes affects multiple cellular functions necessary for maintaining homeostasis.

Pathways

MGAT2 interacts with key proteins in the N-glycan biosynthesis pathway and has connections to the calnexin/calreticulin cycle. In these pathways MGAT2 works with other glycosyltransferases to construct fully mature glycoproteins which are subsequently important for protein folding and quality control. Its interaction with proteins such as MGAT1 and GNPTAB ensures efficient glycoprotein processing and quality control before they achieve their final functional structures.

MGAT2 has associations with carbohydrate-deficient glycoprotein syndrome type II a rare inherited disorder affecting glycosylation. This condition results from mutations in the MGAT2 gene leading to improper glycan branching and subsequent physiological issues. The altered glycosylation impacts various proteins contributing to this multisystem disorder. Additionally variations and malfunctions involving MGAT2 can affect immune response linking it indirectly to immunological conditions although more research is necessary to fully comprehend these connections.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Involved in glycerolipid synthesis and lipid metabolism (PubMed : 12621063, PubMed : 18768481, PubMed : 27184406, PubMed : 28420705). Catalyzes the formation of diacylglycerol, the precursor of triacylglycerol, by transferring the acyl chain of a fatty acyl-CoA to a monoacylglycerol (PubMed : 12621063, PubMed : 27184406). Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes (By similarity). Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18 : 3 > C18 : 2 > C18 : 1 > C18 : 0 at sn-2 (PubMed : 12621063). Able to use 1-monoalkylglycerol (1-MAkG, 1-O-alkylglycerol) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG, 1-O-alkyl-3-acylglycerol or 1-O-alkyl-2-acylglycerol) and subsequently, with lower efficiency, may add another acyl chain producing monoalkyl-diacylglycerol (MADAG, 1-O-alkyl-2,3-diacylglycerol) (PubMed : 28420705). Possesses weak but significant activity with diacylglycerol as substrate, producing triacylglycerol (triacyl-sn-glycerol) (PubMed : 18768481).
See full target information MOGAT2
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Middle East journal of digestive diseases 12:39-44 PubMed32082520

2020

Assessment of Immuno-Histochemical Expression of MBD1 in Colorectal Adenocarcinoma and Its Correlations with Prognostic Factors.

Applications

Unspecified application

Species

Unspecified reactive species

Sholeh Ghaedamini,Mehdi Nikbakht,Mitra Soleimani
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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