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AB191496

Anti-Mkl2 antibody

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(4 제품이 사용된 논문 )

Rabbit Polyclonal Mkl2 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human MRTFB.

대체 명칭 보기

KIAA1243, MKL2, MRTFB, Myocardin-related transcription factor B, MRTF-B, MKL/myocardin-like protein 2, Megakaryoblastic leukemia 2

1 이미지
Western blot - Anti-Mkl2 antibody (AB191496)
  • WB

Supplier Data

Western blot - Anti-Mkl2 antibody (AB191496)

All lanes:

Western blot - Anti-Mkl2 antibody (ab191496)

Lane 1:

HEK293T whole cell lysate

Lane 2:

NIH-3T3 whole cell lysate

Lane 3:

H9C2 whole cell lysate

Predicted band size: 118 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human MRTFB. The exact immunogen used to generate this antibody is proprietary information.

Q9ULH7

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대체품

Primary Antibodies

AB242312

Anti-Mkl2 antibody [CL1546]

Immunocytochemistry/ Immunofluorescence - Anti-Mkl2 antibody [CL1546] (AB242312)

  • 0
  • 0

보완 제품

Primary Antibodies

AB252868

Anti-Serum Response Factor SRF antibody [2C5]

BOND RX™ Validated|Recombinant

Immunoprecipitation - Anti-Serum Response Factor SRF antibody [2C5] (AB252868)

  • 0
  • 0
Primary Antibodies

AB14106

Anti-TAGLN/Transgelin antibody

Immunocytochemistry/ Immunofluorescence - Anti-TAGLN/Transgelin antibody (AB14106)

  • 5
  • 27
Primary Antibodies

AB8580

Anti-Histone H3 (tri methyl K4) antibody - ChIP Grade

BOND RX™ Validated

ChIP - Anti-Histone H3 (tri methyl K4) antibody - ChIP Grade (AB8580)

  • 5
  • 90
Primary Antibodies

AB124964

Anti-alpha smooth muscle Actin antibody [EPR5368]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha smooth muscle Actin antibody [EPR5368] (AB124964)

  • 5
  • 19
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1 - 1/5", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1 - 1/5", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1 - 1/5", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
Purity >95%.
보관 버퍼
Preservative: 0.1% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The Mkl2 protein also known as Myocardin-like 2 or MRTFB is a transcriptional coactivator that primarily interacts with serum response factor (SRF) to regulate gene expression. It has a molecular weight of approximately 118 kDa. Mkl2 is ubiquitously expressed but shows high levels of expression in heart and skeletal muscles. It predominantly resides in the cytoplasm but translocates to the nucleus upon activation.
Biological function summary

Mkl2 influences cytoskeletal dynamics and cellular motility by modulating actin cytoskeleton organization. It forms a complex with SRF to control the transcription of genes involved in these processes. This complex is essential for responding to environmental cues that promote cell differentiation and proliferation.

Pathways

Mkl2 is integral to the RhoA-MRTFA-SRF signaling pathway which links changes in the actin cytoskeleton to transcriptional responses. Mkl2 works in conjunction with proteins like MKL1 to mediate these pathway interactions. Together they coordinate responses to external stimuli that affect cellular architecture and movement.

Mkl2 has implications in cardiac hypertrophy and cancer progression. Aberrant expression or regulation of Mkl2 can lead to pathological cardiac growth impacting heart function. It also associates with oncogenes in the context of cancer promoting tumor cell invasion and metastasis. Understanding its interactions with proteins like MRTFA in these conditions provides potential therapeutic targets for treatment.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation.
See full target information MRTFB
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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Scientific reports 14:3329 PubMed38337011

2024

Cellular senescence is associated with osteonecrosis of the femoral head while mesenchymal stem cell conditioned medium inhibits bone collapse.

Applications

Unspecified application

Species

Unspecified reactive species

Masanori Okamoto,Hiroaki Nakashima,Kiyoshi Sakai,Yasuhiko Takegami,Yusuke Osawa,Junna Watanabe,Sadayuki Ito,Hideharu Hibi,Shiro Imagama

Life science alliance 4: PubMed34389686

2021

Dystrophin involvement in peripheral circadian SRF signalling.

Applications

Unspecified application

Species

Unspecified reactive species

Corinne A Betts,Aarti Jagannath,Tirsa LE van Westering,Melissa Bowerman,Subhashis Banerjee,Jinhong Meng,Maria Sofia Falzarano,Lara Cravo,Graham McClorey,Katharina E Meijboom,Amarjit Bhomra,Wooi Fang Lim,Carlo Rinaldi,John R Counsell,Katarzyna Chwalenia,Elizabeth O'Donovan,Amer F Saleh,Michael J Gait,Jennifer E Morgan,Alessandra Ferlini,Russell G Foster,Matthew Ja Wood

Iranian journal of basic medical sciences 22:745-751 PubMed32373295

2020

The effect of titanium dioxide nanoparticles on mice midbrain substantia nigra.

Applications

Unspecified application

Species

Unspecified reactive species

Zahra Heidari,Abbas Mohammadipour,Parisa Haeri,Alireza Ebrahimzadeh-Bideskan

Molecular medicine reports : PubMed32626937

2020

Downregulation of miR‑142‑5p inhibits human aortic smooth muscle cell proliferation and migration by targeting MKL2.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Wu,Yuqiang Shang,Shiling Dai,Chunjun Yu,Jie Wang
제품이 사용된 논문 모두 보기
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Product promise

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