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AB236501

Anti-MKP-1 antibody [OTI4F10]

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(3 제품이 사용된 논문 )

Mouse Monoclonal MKP-1 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human DUSP1.

대체 명칭 보기

CL100, MKP1, PTPN10, VH1, DUSP1, Dual specificity protein phosphatase 1, Dual specificity protein phosphatase hVH1, Mitogen-activated protein kinase phosphatase 1, Protein-tyrosine phosphatase CL100, MAP kinase phosphatase 1, MKP-1

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI4F10

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human DUSP1.

P28562

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대체품

Primary Antibodies

AB61201

Anti-MKP-1 antibody

Immunohistochemistry paraffin embedded sections - Anti-MKP-1 antibody (AB61201)

  • 0
  • 0
Primary Antibodies

AB217347

Anti-MKP-1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MKP-1 antibody (AB217347)

  • 0
  • 0
Primary Antibodies

AB1351

Anti-MKP-1 antibody

Western blot - Anti-MKP-1 antibody (AB1351)

  • 4
  • 6
Primary Antibodies

AB63548

Anti-MKP-1 (phospho S359) antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MKP-1 (phospho S359) antibody (AB63548)

  • 0
  • 0

보완 제품

Primary Antibodies

AB76310

Anti-DUSP6 antibody [EPR129Y]

RabMAb|Recombinant|KO Validated|20ul selling size

Western blot - Anti-DUSP6 antibody [EPR129Y] (AB76310)

  • 5
  • 16
Primary Antibodies

AB32537

Anti-ERK1 antibody [Y72]

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Flow Cytometry (Intracellular) - Anti-ERK1 antibody [Y72] (AB32537)

  • 5
  • 4
Primary Antibodies

AB16667

Anti-Ki67 antibody [SP6]

BOND RX™ Validated|KO Validated|RabMAb|Advanced Validation|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody [SP6] (AB16667)

  • 5
  • 133
Primary Antibodies

AB62352

Anti-Nrf2 antibody [EP1808Y]

20ul selling size|RabMAb|Recombinant|KO Validated

Western blot - Anti-Nrf2 antibody [EP1808Y] (AB62352)

  • 4
  • 34
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
Purification 관련 사항
Purified from cell culture supernatant.
보관 버퍼
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The protein known as MKP-1 also called DUSP1 is a dual-specificity phosphatase. It acts mechanically by dephosphorylating the phospho-tyrosine and phospho-serine/threonine residues of its target proteins. The protein has a molecular weight of about 39 kDa. MKP-1 is ubiquitously expressed but shows higher levels in specific tissues such as liver lung and brain where it regulates various cellular processes.
Biological function summary

MKP-1 influences cellular responses to stress and inflammation by inactivating mitogen-activated protein kinases (MAPKs). It does not exist as part of a permanent complex but temporarily interacts with MAPKs. By dephosphorylating these kinases MKP-1 modulates gene expression cell proliferation and apoptosis. Through these interactions the protein plays a significant role in protecting cells from excessive inflammatory signals and stress-induced damage.

Pathways

The MKP-1 protein is integral to the MAPK signaling pathway and the JNK signaling cascade. MKP-1 directly affects the balance of MAPK-related proteins such as ERK JNK and p38 to help regulate various cellular outcomes. By dephosphorylating these proteins MKP-1 acts as a negative feedback regulator ensuring that cellular responses to external stimuli are controlled and do not become harmful.

MKP-1 is associated with inflammatory diseases and cancer. Inflammatory disorders such as rheumatoid arthritis show link with aberrant regulation of MKP-1 as it often interacts with MAPKs involved in inflammation. In cancer altered MKP-1 expression can affect tumor growth and progression due to its regulatory role on cell proliferation pathways. The protein's interaction with key signaling molecules in these diseases highlights its potential as a therapeutic target.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
See full target information DUSP1
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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The Korean journal of pain 37:320-331 PubMed39344360

2024

Down-regulation of microRNA-382-5p reduces neuropathic pain by targeting regulation of dual specificity phosphatase-1.

Applications

Unspecified application

Species

Unspecified reactive species

Anjie Xu,Huili Shen,Shasha Mei,Zhongwei Wang,Qiuyi Xie,Huaqing Cui,Yunchao Chu,Baihe Feng

Science signaling 15:eabj6915 PubMed35380879

2022

The toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Spyridoula-Angeliki Nikou,Chunsheng Zhou,James S Griffiths,Natalia K Kotowicz,Bianca M Coleman,Mary J Green,David L Moyes,Sarah L Gaffen,Julian R Naglik,Peter J Parker

BMC molecular biology 20:21 PubMed31438862

2019

MiR-32-5p influences high glucose-induced cardiac fibroblast proliferation and phenotypic alteration by inhibiting DUSP1.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Shen,Wanhong Xing,Rui Liu,Yiying Zhang,Chunhong Xie,Fangqi Gong
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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