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AB236400

Anti-MKX antibody [OTI6A12]

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(2 제품이 사용된 논문 )

Mouse Monoclonal MKX antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MKX.

대체 명칭 보기

C10orf48, IRXL1, MKX, Homeobox protein Mohawk

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MKX antibody [OTI6A12] (AB236400)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MKX antibody [OTI6A12] (AB236400)

Paraffin-embedded human prostate tissue stained for MKX using ab236400 at 1/150 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MKX antibody [OTI6A12] (AB236400)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MKX antibody [OTI6A12] (AB236400)

Paraffin-embedded human prostate carcinoma tissue stained for MKX using ab236400 at 1/150 dilution in immunohistochemical analysis.

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI6A12

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human MKX.

Q8IYA7

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보완 제품

Primary Antibodies

AB138492

Anti-Collagen I antibody [EPR7785]

20ul selling size|BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials

Immunohistochemistry (Frozen sections) - Anti-Collagen I antibody [EPR7785] (AB138492)

  • 4
  • 37
Primary Antibodies

AB203676

Anti-tenomodulin antibody

Western blot - Anti-tenomodulin antibody (AB203676)

  • 4
  • 7
Primary Antibodies

AB34712

Anti-Collagen II antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Collagen II antibody (AB34712)

  • 4
  • 16
Primary Antibodies

AB181602

Anti-GAPDH antibody [EPR16891] - Loading Control

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GAPDH antibody [EPR16891] - Loading Control (AB181602)

  • 5
  • 23
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/150", "IHCP-species-notes": "<p>Heat-induced epitope retrieval by 1 mM EDTA in 10 mM Tris, pH 8.5, 120°C for 3 minutes.</p>" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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제품 세부 정보

Clone OTI6A12 (formerly 6A12).
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
Purification 관련 사항
Purified from cell culture supernatant.
보관 버퍼
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

MKX also known as Mohawk Homeobox is a transcription factor with a mass of approximately 36 kDa. This protein plays a role in gene regulation by binding to DNA sequences and influencing the expression of target genes. MKX mainly expresses in mesodermal tissues especially in skeletal muscles tendons and ligaments during development. Its expression is spatially and temporally regulated reflecting its involvement in tissue-specific processes.
Biological function summary

MKX influences the formation and maintenance of fibrous connective tissues. It does not function as part of a known complex but interacts with other transcription factors to regulate gene expression patterns essential for tissue differentiation and function. MKX is involved in orchestrating the development of musculoskeletal structures by modulating the expression of genes related to extracellular matrix composition and organization. Through these actions MKX contributes to the structural integrity and mechanical properties of tendons and ligaments.

Pathways

MKX plays a role in the tendon development and TGF-β signaling pathways. In these pathways MKX coordinates with proteins such as Scleraxis (SCX) and Tenomodulin (TNMD) to promote tendon and ligament differentiation. The interaction of MKX within these pathways facilitates cellular processes that mediate tissue formation and repair indicating its integral role in connective tissue physiology.

MKX has strong connections to conditions involving tendon and ligament degeneration such as tendinopathy and osteoarthritis. Altered expression levels or mutations in MKX may disrupt normal tissue development and repair processes linking it to these disorders. Furthermore MKX interacts with proteins like Matrix Metalloproteinases (MMPs) which play a role in tissue remodeling and are involved in pathological conditions when dysregulated. Understanding the functions and interactions of MKX aids in exploring therapeutic targets for musculoskeletal diseases.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

May act as a morphogenetic regulator of cell adhesion.
See full target information MKX
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of tissue engineering 16:20417314251315185 PubMed39882545

2025

Therapeutic potential and mechanisms of umbilical cord mesenchymal stem cells differentiating into tendon cells and promotion of rotator cuff tendon-bone healing.

Applications

Unspecified application

Species

Unspecified reactive species

Youliang Shen,Yuelei Wang,Yidan Xu,Jie Wang,Chuqiang Yin,Zengshuai Han,Feng Shen,Ting Wang

Aging 15:3807-3825 PubMed37166429

2023

Identification and validation of metabolism-related genes signature and immune infiltration landscape of rheumatoid arthritis based on machine learning.

Applications

Unspecified application

Species

Unspecified reactive species

Zhaoyang Guo,Yuanye Ma,Yaqing Wang,Hongfei Xiang,Huifei Cui,Zuoran Fan,Youfu Zhu,Dongming Xing,Bohua Chen,Hao Tao,Zhu Guo,Xiaolin Wu
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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