JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB111942

Anti-MLH3 antibody

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Rabbit Polyclonal MLH3 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MLH3 aa 1 to C-terminus.

대체 명칭 보기

DNA mismatch repair protein Mlh3, MutL protein homolog 3, MLH3

1 이미지
Western blot - Anti-MLH3 antibody (AB111942)
  • WB

Unknown

Western blot - Anti-MLH3 antibody (AB111942)

5% SDS PAGE

All lanes:

Western blot - Anti-MLH3 antibody (ab111942) at 1/1000 dilution

All lanes:

HCT116 whole cell lysate at 30 µg

Predicted band size: 142 kDa,164 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human MLH3 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9UHC1

style
left-column

대체품

Primary Antibodies

AB221066

Anti-MLH3 antibody

Immunocytochemistry/ Immunofluorescence - Anti-MLH3 antibody (AB221066)

  • 0
  • 0
Primary Antibodies

AB4834

Anti-MLH3 antibody

Immunocytochemistry/ Immunofluorescence - Anti-MLH3 antibody (AB4834)

  • 0
  • 0

보완 제품

Primary Antibodies

AB110638

Anti-PMS2 antibody [EPR3947]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PMS2 antibody [EPR3947] (AB110638)

  • 4
  • 3
Primary Antibodies

AB92312

Anti-MLH1 antibody [EPR3894]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-MLH1 antibody [EPR3894] (AB92312)

  • 5
  • 4
Primary Antibodies

AB70270

Anti-MSH2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-MSH2 antibody (AB70270)

  • 5
  • 4
Primary Antibodies

AB92471

Anti-MSH6 antibody [EPR3945]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|KO Validated|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MSH6 antibody [EPR3945] (AB92471)

  • 5
  • 5
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
ab111942 is purified by antigen-affinity chromatography.
보관 버퍼
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

MLH3 also known as MutL homolog 3 is a DNA mismatch repair protein part of the MutL family. It has a molecular mass of approximately 160 kilodaltons (kDa). This protein is mainly expressed in the testis and also found in various other tissues at lower levels. MLH3 plays a mechanical role in DNA repair through the correction of mismatches that occur during replication.
Biological function summary

MLH3 acts within DNA mismatch repair processes to maintain genomic stability. It forms heterodimeric complexes with MLH1 another MutL homolog which is essential for its DNA repair function. This complex carries out the recognition and repair of insertion-deletion loops and base-base mismatches in DNA therefore ensuring fidelity during cell division.

Pathways

MLH3 operates within the DNA damage response and repair pathways. It interacts significantly with the MLH1 protein to facilitate mismatch repair activities. Additionally MLH3 participates in the homologous recombination pathway working alongside proteins such as MSH2 to secure proper chromosome segregation during meiosis.

MLH3 mutations or dysfunctions have associations with Lynch syndrome a hereditary condition that increases cancer risk especially colorectal cancer. Alterations in MLH3 in combination with MLH1 mutations have implications for mismatch repair deficiencies observed in these disorders. Additionally variances in MLH3 contribute to the progression of endometrial cancer often linked with other mismatch repair proteins like MSH6 in the disease pathology.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Probably involved in the repair of mismatches in DNA.
See full target information MLH3
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Scientific reports 8:4670 PubMed29549309

2018

Coupling of SK channels, L-type Ca channels, and ryanodine receptors in cardiomyocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Dong Zhang,Zana A Coulibaly,Wei Chun Chen,Hannah A Ledford,Jeong Han Lee,Padmini Sirish,Gu Dai,Zhong Jian,Frank Chuang,Ingrid Brust-Mascher,Ebenezer N Yamoah,Ye Chen-Izu,Leighton T Izu,Nipavan Chiamvimonvat
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com