JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB243596

Anti-MMAB antibody

Be the first to review this product! 리뷰 제출

|

(0 출판물)

Rabbit Polyclonal MMAB antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MMAB aa 150 to C-terminus.

대체 명칭 보기

Corrinoid adenosyltransferase MMAB, ATP:co(I)rrinoid adenosyltransferase MMAB, Methylmalonic aciduria type B protein, MMAB

2 이미지
Immunocytochemistry/ Immunofluorescence - Anti-MMAB antibody (AB243596)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-MMAB antibody (AB243596)

Paraformaldehyde-fixed, Triton X-100 permeabilized A431 (human epidermoid carcinoma cell line) cells labeling MMAB (Green) using ab243596 at 4 μg/mL in ICC/IF analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMAB antibody (AB243596)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMAB antibody (AB243596)

Formalin-fixed, paraffin-embedded human liver tissue stained for MMAB using ab243596 at 1/500 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human MMAB aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q96EY8

style
left-column

대체품

Primary Antibodies

AB174831

Anti-MMAB antibody [EPR8695]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-MMAB antibody [EPR8695] (AB174831)

  • 0
  • 0

보완 제품

Proteins & Peptides

AB99217

Recombinant Human MMAB protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human MMAB protein (His tag N-Terminus) (AB99217)

  • 0
  • 0
Primary Antibodies

AB213224

Anti-Histone H3 (tri methyl K4) antibody [EPR20551-225] - ChIP Grade

20ul selling size|RabMAb|Advanced Validation|Recombinant

ChIP - Anti-Histone H3 (tri methyl K4) antibody [EPR20551-225] - ChIP Grade (AB213224)

  • 4
  • 6
Primary Antibodies

AB192985

Anti-Histone H3 (tri methyl K27) antibody [EPR18607] - ChIP Grade

20ul selling size|RabMAb|Advanced Validation|Recombinant

ChIP-sequencing - Anti-Histone H3 (tri methyl K27) antibody [EPR18607] - ChIP Grade (AB192985)

  • 4
  • 14
Primary Antibodies

AB175310

Anti-ADA antibody

Immunocytochemistry/ Immunofluorescence - Anti-ADA antibody (AB175310)

  • 4
  • 1
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

MMAB also known as methylmalonic aciduria type B protein plays a critical role in the conversion of certain molecules within the mitochondria. This protein weighing approximately 38 kDa assists in the conversion of vitamin B12 into adenosylcobalamin an active coenzyme form. MMAB is present in many tissues with significant expression in liver and kidney where significant mitochondrial activities occur. Methylmalonyl-CoA a byproduct needing processing for energy production relies on MMAB for transformation.
Biological function summary

MMAB is indispensable for vitamin B12 metabolism and mitochondrial function. This protein acts within a larger enzymatic complex that converts methylmalonyl-CoA to succinyl-CoA. By playing a role in this conversion MMAB facilitates the Krebs cycle an essential biochemical pathway for energy production. Its interaction with other proteins like methylmalonyl-CoA mutase ensures proper biochemical transformations highlighting its importance in metabolic processes.

Pathways

Methylmalonic acidemia results from disruptions in the MMAB-mediated pathway notably affecting energy metabolism. This protein integrates into the mitochondrial pathway that handles odd-chain fatty acids and amino acid breakdown. The effective collaboration of MMAB with methylmalonyl-CoA mutase ensures efficient functioning within these pathways linking MMAB to essential metabolic activities like gluconeogenesis and energy production.

Mutations in MMAB contribute to methylmalonic acidemia a metabolic disorder characterized by accumulation of methylmalonic acid in the body. This condition can lead to developmental delay metabolic crisis and other severe symptoms if untreated. Alongside methylmalonyl-CoA mutase MMAB mutations impact vitamin B12-related pathways highlighting their joint role in this genetic disorder. Early diagnosis and treatment targeting this pathway help mitigate symptoms related to these enzymatic dysfunctions.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Converts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), a coenzyme for methylmalonyl-CoA mutase, therefore participates in the final step of the vitamin B12 conversion (PubMed : 12514191). Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer that is stimulated by ATP-binding to MMAB and gated by MMAA (Probable).
See full target information MMAB
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com