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AB236510

Anti-MMP11 antibody [OTI3E10]

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Mouse Monoclonal MMP11 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MMP11 aa 200 to C-terminus.

대체 명칭 보기

STMY3, MMP11, Stromelysin-3, SL-3, ST3, Matrix metalloproteinase-11, MMP-11

2 이미지
Western blot - Anti-MMP11 antibody [OTI3E10] (AB236510)
  • WB

Supplier Data

Western blot - Anti-MMP11 antibody [OTI3E10] (AB236510)

All lanes:

Western blot - Anti-MMP11 antibody [OTI3E10] (ab236510) at 1/500 dilution

Lane 1:

MDA-MB-231 (human breast adenocarcinoma cell line) whole cell lysate at 35 µg

Lane 2:

T-47D (human ductal breast epithelial tumor cell line) whole cell lysate at 35 µg

Predicted band size: 55 kDa

false

Western blot - Anti-MMP11 antibody [OTI3E10] (AB236510)
  • WB

Supplier Data

Western blot - Anti-MMP11 antibody [OTI3E10] (AB236510)

All lanes:

Western blot - Anti-MMP11 antibody [OTI3E10] (ab236510) at 1/500 dilution

Lane 1:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) transfected with pCMV6-ENTRY control at 5 µg

Lane 2:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) transfected with pCMV6-ENTRY MMP11 at 5 µg

Predicted band size: 55 kDa

false

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI3E10

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human MMP11 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P24347

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대체품

Primary Antibodies

AB119284

Anti-MMP11 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP11 antibody (AB119284)

  • 0
  • 0
Primary Antibodies

AB53143

Anti-MMP11 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP11 antibody (AB53143)

  • 4
  • 1

보완 제품

Primary Antibodies

AB215715

Anti-TGF beta 1 antibody [EPR21143]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|KO Validated

Western blot - Anti-TGF beta 1 antibody [EPR21143] (AB215715)

  • 5
  • 7
Primary Antibodies

AB282457

Anti-EpCAM antibody [RM1016]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunocytochemistry - Anti-EpCAM antibody [RM1016] (AB282457)

  • 3
  • 1
Primary Antibodies

AB276139

Anti-TIMP3 antibody [EPR23943-149] - BSA and Azide free

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-TIMP3 antibody [EPR23943-149] - BSA and Azide free (AB276139)

  • 0
  • 0
Primary Antibodies

AB181118

Anti-MMP23 antibody [EPR7769]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-MMP23 antibody [EPR7769] (AB181118)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
Purification 관련 사항
Purified from cell culture supernatant.
보관 버퍼
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

MMP11 also known as stromelysin-3 is a matrix metalloproteinase with a mass of approximately 54 kDa. It participates in the breakdown of extracellular matrix components particularly during tissue remodeling and wound healing. MMP11 demonstrates unique mechanical behavior when compared to other MMPs as it prefers cleaving non-matrix substrates like alpha1-proteinase inhibitor. Expression levels of MMP11 vary but are commonly found in tissues undergoing active remodeling including the placenta and stroma of breast tumors.
Biological function summary

The modulation of the extracellular matrix by MMP11 helps in regulating tissue architecture and cellular interactions. Unlike other MMPs MMP11 does not participate in large protein complexes but acts mainly at the cellular boundaries. It helps facilitate tumor cell invasion by altering the local matrix environment and can modify growth factor activity aiding in cell proliferation and migration.

Pathways

MMP11 is deeply integrated into the tissue remodeling and invasion pathways. It associates with the serine protease pathway known for its role in regulating the extracellular environment. MMP11 is linked to proteins like TIMP1 which is a natural inhibitor and works together in maintaining the balance of extracellular matrix deposition and degradation.

Overexpression of MMP11 is frequently observed in various cancers such as breast and gastric cancer. Its contribution to tumor progression makes it a significant focus in cancer research. MMP11's interaction with other factors like insulin-like growth factor binding proteins influences cellular processes that compromise tissue integrity further linking it to cancer metastasis and progression. This relationship highlights its potential as a therapeutic target in oncology.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

May play an important role in the progression of epithelial malignancies.
See full target information MMP11
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

eLife 12: PubMed37010266

2023

Single-cell RNA-seq of heart reveals intercellular communication drivers of myocardial fibrosis in diabetic cardiomyopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Li,Xinqi Lou,Yingjie Zha,Yinyin Qin,Jun Zha,Lei Hong,Zhanli Xie,Shudi Yang,Chen Wang,Jianzhong An,Zhenhao Zhang,Shigang Qiao
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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