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AB231096

Anti-MMP12 antibody

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(1 출판물)

Rabbit Polyclonal MMP12 antibody. Suitable for WB and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Rat Mmp12 aa 100-300.

대체 명칭 보기

Mmel, Mmp12, Macrophage metalloelastase, MME, Matrix metalloproteinase-12, MMP-12

5 이미지
Western blot - Anti-MMP12 antibody (AB231096)
  • WB

Supplier Data

Western blot - Anti-MMP12 antibody (AB231096)

All lanes:

Western blot - Anti-MMP12 antibody (ab231096) at 1 µg/mL

All lanes:

Rat liver lysate

Predicted band size: 54 kDa

false

Western blot - Anti-MMP12 antibody (AB231096)
  • WB

Supplier Data

Western blot - Anti-MMP12 antibody (AB231096)

All lanes:

Western blot - Anti-MMP12 antibody (ab231096) at 2 µg/mL

All lanes:

Rat small intestine lysate

Predicted band size: 54 kDa

false

Western blot - Anti-MMP12 antibody (AB231096)
  • WB

Supplier Data

Western blot - Anti-MMP12 antibody (AB231096)

All lanes:

Western blot - Anti-MMP12 antibody (ab231096) at 2 µg/mL

All lanes:

Rat thymus lysate

Predicted band size: 54 kDa

false

Western blot - Anti-MMP12 antibody (AB231096)
  • WB

Supplier Data

Western blot - Anti-MMP12 antibody (AB231096)

All lanes:

Western blot - Anti-MMP12 antibody (ab231096) at 2 µg/mL

All lanes:

Rat spinal cord lysate

Predicted band size: 54 kDa

false

Western blot - Anti-MMP12 antibody (AB231096)
  • WB

Supplier Data

Western blot - Anti-MMP12 antibody (AB231096)

All lanes:

Western blot - Anti-MMP12 antibody (ab231096) at 2 µg/mL

All lanes:

Recombinant rat MMP12 protein

Predicted band size: 54 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Rat Mmp12 aa 100-300. The exact immunogen used to generate this antibody is proprietary information.

Q63341

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대체품

Primary Antibodies

AB239851

Anti-MMP12 antibody [EP1261Y] - BSA and Azide free

RabMAb|Recombinant

Immunoprecipitation - Anti-MMP12 antibody [EP1261Y] - BSA and Azide free (AB239851)

  • 0
  • 0
Primary Antibodies

AB137444

Anti-MMP12 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP12 antibody (AB137444)

  • 4
  • 1
Primary Antibodies

AB52897

Anti-MMP12 antibody [EP1261Y]

20ul selling size|RabMAb|Recombinant

Immunoprecipitation - Anti-MMP12 antibody [EP1261Y] (AB52897)

  • 0
  • 0

보완 제품

Assay Kits

AB246540

Mouse MMP12 ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Mouse MMP12 ELISA Kit (AB246540)

  • 0
  • 0
Primary Antibodies

AB28230

Anti-Urokinase antibody [H77A10]

Western blot - Anti-Urokinase antibody [H77A10] (AB28230)

  • 0
  • 0
Primary Antibodies

AB307895

Anti-uPA Receptor/U-PAR antibody [EPR26916-73]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|Trial Size

Immunohistochemistry - Anti-uPA Receptor/U-PAR antibody [EPR26916-73] (AB307895)

  • 0
  • 0
Primary Antibodies

AB138492

Anti-Collagen I antibody [EPR7785]

20ul selling size|BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials

Immunohistochemistry (Frozen sections) - Anti-Collagen I antibody [EPR7785] (AB138492)

  • 4
  • 37
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
ab231096 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Matrix metallopeptidase 12 commonly known as MMP12 or macrophage elastase is an enzyme with a molecular mass of approximately 54 kDa. Found mainly in macrophages MMP12 belongs to the matrix metallopeptidase family. It functions to break down extracellular matrix proteins specifically elastin. Besides macrophages it sees expression in other tissues including the lungs and skin but it holds particular importance in immune cell-related environments.
Biological function summary

MMP12 plays an important role in tissue remodeling and repair processes. It interacts with other proteases within the extracellular matrix. The degradation of elastin by MMP12 contributes to structural organization and it participates in immune response modulation. As part of the matrix metalloproteinase family MMP12 takes part in the larger proteolytic system which comprises multiple enzymes working in concert.

Pathways

MMP12 is an essential factor in the extracellular matrix degradation pathway. This pathway regulates tissue remodeling and inflammatory response. MMP12 independently breaks down elastin while it interacts with proteins like MMP2 and MMP9 which assist in remodeling processes. It also contributes to the regulation of cytokines that orchestrate immune functions.

Overexpression of MMP12 is strongly linked to chronic obstructive pulmonary disease (COPD) and atherosclerosis. In COPD MMP12's breakdown of elastin contributes to tissue damage in the lung. In atherosclerosis the enzyme accelerates plaque destabilization impacting cardiovascular health. Additionally MMP12 shares functional relationships with proteins such as TIMPs (tissue inhibitors of metalloproteinases) which regulate its activity and play roles in disease pathogenesis.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3 (By similarity).
See full target information Mmp12
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Scientific reports 14:3517 PubMed38347040

2024

Aqueous humor TGFβ and fibrillin-1 in Tsk mice reveal clues to POAG pathogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

James C Tan,MinHee K Ko,Jeong-Im Woo,Kenneth L Lu,Jonathan A Kelber
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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