AB233004

Anti-MMP24 antibody

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Rabbit Polyclonal MMP24 antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MMP24 aa 400 to C-terminus.

대체 명칭 보기

MT5MMP, MMP24, Matrix metalloproteinase-24, MMP-24, Membrane-type matrix metalloproteinase 5, Membrane-type-5 matrix metalloproteinase, MT-MMP 5, MTMMP5, MT5-MMP

11 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)

Formalin-fixed, paraffin-embedded human skin cancer tissue stained for MMP24 using ab233004 at 10 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)

Formalin-fixed, paraffin-embedded human liver tissue stained for MMP24 using ab233004 at 10 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)

Formalin-fixed, paraffin-embedded human kidney tissue stained for MMP24 using ab233004 at 10 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)

Formalin-fixed, paraffin-embedded human stomach cancer tissue stained for MMP24 using ab233004 at 10 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)

Formalin-fixed, paraffin-embedded human colorectal cancer tissue stained for MMP24 using ab233004 at 10 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Rat cerebrum lysate

Predicted band size: 73 kDa

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주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MMP24 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9Y5R2

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

Purification 관련 사항

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

보관 버퍼

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Matrix Metalloproteinase 24 (MMP24) also known as MT5-MMP is an enzyme that plays a significant role in tissue remodeling and degradation of extracellular matrix components. This enzyme is membrane-anchored unlike its soluble counterparts and has a mass of approximately 72 kDa. MMP24 is expressed in neuronal tissues and shows high levels of activity in the brain and other parts of the central nervous system as well as in certain cancer cell types. MMP24 is implicated in several cellular processes due to its ability to cleave a variety of substrates.

Biological function summary

The enzyme is involved in the modulation of synaptic connections and neural plasticity. MMP24 functions as part of a complex which includes pro-protein convertases that activate the enzyme from its pro-form. These activities highlight its contribution to the regulation of neural networks. MMP24's interaction with neuronal substrates and their subsequent processing is vital for maintaining normal neural architecture and response to recovery processes after injury.

Pathways

MMP24 holds a significant role in the extracellular matrix (ECM) remodeling pathway and is linked to the integrin signaling pathway. These pathways are important for cell adhesion migration and survival. In the ECM remodeling pathway MMP24 interacts with other metalloproteinases such as MMP2 and MMP9 highlighting its contribution to the dynamic remodeling processes. In the integrin signaling pathway its activity affects cell-matrix interactions emphasizing its importance in cellular communication and structural organization within tissues.

Abnormalities in MMP24 expression and activity associate with neurodegenerative diseases like Alzheimer's and certain types of cancer including glioma. MMP24’s involvement in cancer emphasizes its role in promoting cancer cell invasion and metastasis due to its ECM degrading capability. It works in connection with other proteins like MMP14 which also plays a significant role in tumor progression and response to tumor microenvironmental changes. Understanding the regulation and activity of MMP24 could offer therapeutic insights into these pathological conditions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity).

See full target information MMP24

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature communications 16:4124 PubMed40319020

2025

Non-canonical Wnt signaling promotes epithelial fluidization in the repairing airway.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel Jun-Kit Hu,Xiaoyu Tracy Cai,Jesse Simons,Jina Yun,Justin Elstrott,Heinrich Jasper

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-MMP24 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)

Western blot - Anti-MMP24 antibody (AB233004)

Western blot - Anti-MMP24 antibody (AB233004)

Western blot - Anti-MMP24 antibody (AB233004)

Western blot - Anti-MMP24 antibody (AB233004)

Western blot - Anti-MMP24 antibody (AB233004)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise