AB150415

Anti-MMP27 antibody [EPR7543]

RabMAb
Recombinant
각 태그의 뜻

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Rabbit Recombinant Monoclonal MMP27 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

1 이미지

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Western blot - Anti-MMP27 antibody [EPR7543] (AB150415)

All lanes:

Western blot - Anti-MMP27 antibody [EPR7543] (ab150415) at 1/1000 dilution

Lane 1:

Caco-1 cell lysate at 10 µg

Lane 2:

Human fetal lung cell lysate at 10 µg

Lane 3:

Raji cell lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP at 1/2000 dilution

Predicted band size: 59 kDa

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주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR7543

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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제품 세부 정보

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

배송 시 보관 조건

Conditional Ambient

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

MMP27 also known as matrix metallopeptidase 27 is part of the matrix metalloproteinases (MMPs) family. This protein has a molecular mass of approximately 54 kDa. MMPs are known for their role in cleaving extracellular matrix components. MMP27 expresses in several human tissues including lymphoid organs like the spleen and lymph nodes. It involves in processes related to tissue remodeling and repair as well as immune functions.

Biological function summary

MMP27 participates in the breakdown of proteins in the extracellular matrix. It does this as a monomer unlike some other metalloproteinases that form complexes. Although its specific substrate preferences are not completely characterized MMP27 likely interacts with proteoglycans and collagen influencing the structural components of cells and tissues. This enables various cell migration and differentiation events.

Pathways

Enzymes of the MMP family like MMP27 play roles in the connective tissue remodeling pathway and the immune response regulation pathway. In these pathways MMP27 interacts with other proteins such as TIMPs (tissue inhibitors of metalloproteinases) which regulate its activity. The balance between MMPs and TIMPs is vital for maintaining tissue homeostasis and proper immune system function.

Irregular expression or activity of MMP27 can relate to disorders like cancer and rheumatoid arthritis. MMP27’s role in degrading extracellular matrix components affects tumor progression and inflammation. In cancer it may interact with other MMPs such as MMP9 facilitating metastasis. In rheumatoid arthritis MMP27 could contribute to joint inflammation and destruction of cartilage interacting with cytokines that modulate inflammatory responses.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens.

See full target information MMP27

대체 명칭 보기

UNQ2503/PRO5992, MMP27, Matrix metalloproteinase-27, MMP-27

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Proceedings of the National Academy of Sciences of 115:E9687-E9696 PubMed30254165

2018

Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Sarah K Baker,Zu-Lin Chen,Erin H Norris,Alexey S Revenko,A Robert MacLeod,Sidney Strickland

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-MMP27 antibody [EPR7543]

Western blot - Anti-MMP27 antibody [EPR7543] (AB150415)

관련 conjugated 항체와 다양한 조성의 항체 (1)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (1)

Product promise