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AB242878

Anti-MMP8 antibody [EPR19122-130] - BSA and Azide free (Detector)

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Rabbit Recombinant Monoclonal MMP8 antibody. Carrier free. Suitable for sELISA and reacts with Human samples.

대체 명칭 보기

CLG1, MMP8, Neutrophil collagenase, Matrix metalloproteinase-8, PMNL collagenase, MMP-8, PMNL-CL

1 이미지
Sandwich ELISA - Anti-MMP8 antibody [EPR19122-130] - BSA and Azide free (Detector) (AB242878)
  • sELISA

Supplier Data

Sandwich ELISA - Anti-MMP8 antibody [EPR19122-130] - BSA and Azide free (Detector) (AB242878)

Representative standard curve from corresponding SimpleStep ELISA® Kit (ab219050).

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR19122-130

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

sELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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보완 제품

Assay Kits

AB219050

Human MMP8 ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human MMP8 ELISA Kit (AB219050)

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Primary Antibodies

AB314791

Anti-CD36 antibody [EPR26635-8] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-CD36 antibody [EPR26635-8] - BSA and Azide free (Capture) (AB314791)

  • 0
  • 0
Primary Antibodies

AB245029

Anti-GITR antibody [EPR20427-30] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-GITR antibody [EPR20427-30] - BSA and Azide free (Detector) (AB245029)

  • 0
  • 0
Primary Antibodies

AB259755

Anti-YKL-40/CHI3L1 antibody [EPR22243-81] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-YKL-40/CHI3L1 antibody [EPR22243-81] - BSA and Azide free (Capture) (AB259755)

  • 0
  • 0
Primary Antibodies

AB288623

Anti-ICAM1 antibody [YCA-R24639-179 H3L2] - BSA and Azide free (Detector)

Recombinant

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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제품 세부 정보

ab242878 is a BSA and Azide Free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human MMP8. The recommended pair for sandwich ELISA is:
Capture: ab242633, Human MMP8 Capture Antibody (unconjugated)
Detector: ab242878, Human MMP8 Detector Antibody (unconjugated)
The reference range value is 31.2 - 2000 pg/ml.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Sandwich ELISA
The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.

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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Matrix metalloproteinase-8 (MMP-8) also known as neutrophil collagenase is an enzyme with a molecular weight of approximately 57 kDa. It belongs to the matrix metalloproteinase family which is involved in the breakdown of extracellular matrix components. MMP-8 mainly expresses in neutrophils but can also be found in other tissues such as the skin lungs and liver. The expression of MMP-8 increases during inflammation and infection where it plays a critical role in tissue remodeling and repair processes.
Biological function summary

MMP-8 participates in the degradation of collagen types I II and III contributing to extracellular matrix remodeling. It acts independently rather than being part of a larger enzyme complex. Its activity is tightly regulated by tissue inhibitors of metalloproteinases (TIMPs) to prevent excessive tissue damage. By modulating the extracellular matrix MMP-8 influences processes like wound healing cell migration and angiogenesis indicating its essential role in maintaining tissue homeostasis.

Pathways

MMP-8 plays a role in the inflammatory response and wound healing pathways. It interacts with and processes other proteins like pro-inflammatory cytokines and growth factors which are important for regulating these pathways. MMP-8 collaborates with matrix metalloproteinase-9 (MMP-9) in the inflammatory pathway to facilitate leukocyte migration and rapid tissue remodeling during acute inflammatory responses. Its regulation involves complex interactions among proteolytic enzymes emphasizing its function in balancing matrix degradation and formation.

MMP-8 is associated with periodontal disease and rheumatoid arthritis. In periodontal disease elevated MMP-8 levels can lead to breakdown of connective tissue and bone contributing to tooth loss. In rheumatoid arthritis MMP-8 alongside MMP-1 degrades joint cartilage collagen exacerbating the inflammation and joint damage. These associations underline MMP-8's potential as a biomarker for these diseases and highlight the need for MMP-8 testing tools such as MMP8 ELISA kits to monitor disease progression and treatment efficacy.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Can degrade fibrillar type I, II, and III collagens.
See full target information MMP8
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Product promise

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