AB235395

Anti-MND1 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal MND1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MND1.

대체 명칭 보기

GAJ, MND1, Meiotic nuclear division protein 1 homolog

2 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MND1 antibody (AB235395)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MND1 antibody (AB235395)

Paraffin-embedded human endometrial cancer tissue stained for MND1 with ab235395 (1/100 dilution) in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MND1 antibody (AB235395)

Paraffin-embedded human gastric cancer tissue stained for MND1 with ab235395 (1/100 dilution) in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human MND1.

Q9BWT6

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

Purification 관련 사항

Purity >95%

보관 버퍼

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The MND1 protein also known by its full name Meiotic Nuclear Divisions 1 plays a mechanical role in the process of homologous recombination. Its molecular mass is approximately 25 kDa which is quite small. MND1 expresses in germ cells specifically during the meiotic phase of cell division. This expression has been noted in both male and female gametogenesis which is essential for proper chromosomal synapsis and disassembly.

Biological function summary

MND1 works alongside other proteins to ensure successful meiotic recombination. It often forms a complex with the protein HOP2 which enhances its function. This complex improves the pairing and alignment of homologous chromosomes during meiosis. Through this interaction MND1 influences genetic diversity by allowing the exchange of genetic material between chromosomes a necessary process for the formation of viable gametes.

Pathways

MND1 interacts within genetic recombination pathways that are important for accurate chromosome segregation. It performs important functions in the homologous recombination repair pathway. Specifically the MND1-HOP2 complex works closely with proteins such as RAD51 and DMC1 which are also involved in DNA repair and strand invasion during meiosis. These interactions facilitate the correction of DNA double-strand breaks ensuring stability and integrity of the genetic material.

Mutations or malfunctions in MND1 can lead to meiotic arrest and infertility. Research indicates that improper function or expression of MND1 may be implicated in certain cases of sterility in both males and females. The MND1-HOP2 complex has shown associations with these fertility issues highlighting its importance in normal reproductive health. Understanding the MND1 pathway could potentially lead to new insights into treatments for infertility issues.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.

See full target information MND1

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular cell 85:815-828.e10 PubMed39879985

2025

Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase.

Applications

Unspecified application

Species

Unspecified reactive species

Sara Carrillo Roas,Yuichi Yagita,Paul Murphy,Robert Kurzbauer,Tim Clausen,Eszter Zavodszky,Ramanujan S Hegde

Aging 14:7416-7442 PubMed36098680

2022

MND1 functions as a potential prognostic biomarker associated with cell cycle and immune infiltration in kidney renal clear cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jiayu Fang,Jing Zhen,Yiyang Gong,Yun Ke,Bidong Fu,Yike Jiang,Jing Xie,Yue Liu,Yongqi Ding,Da Huang,Fan Xiao

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-MND1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MND1 antibody (AB235395)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MND1 antibody (AB235395)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (2)

Product promise