JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB151015

Anti-MOCOS/MCS antibody

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Rabbit Polyclonal MOCOS/MCS antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication.

대체 명칭 보기

Molybdenum cofactor sulfurase, MCS, MOS, MoCo sulfurase, hMCS, Molybdenum cofactor sulfurtransferase, MOCOS

3 이미지
Immunocytochemistry/ Immunofluorescence - Anti-MOCOS/MCS antibody (AB151015)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-MOCOS/MCS antibody (AB151015)

RT4 cells stained for MOCOS/MCS (green) using ab151015 at 2 μg/ml dilution in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOCOS/MCS antibody (AB151015)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOCOS/MCS antibody (AB151015)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human stomach tissue labelling MOCOS/MCS with ab151015 at 1/50 dilution

Western blot - Anti-MOCOS/MCS antibody (AB151015)
  • WB

Supplier Data

Western blot - Anti-MOCOS/MCS antibody (AB151015)

All lanes:

Western blot - Anti-MOCOS/MCS antibody (ab151015)

Lane 1:

Molecular ladder

Lane 2:

RT4 cell lysate at 0.4 µg/mL

Predicted band size: 98 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

style
left-column

보완 제품

Primary Antibodies

AB18184

Anti-6X His tag® antibody [HIS.H8]

Lab Essentials

Western blot - Anti-6X His tag® antibody [HIS.H8] (AB18184)

  • 5
  • 32
Primary Antibodies

AB219465

Anti-6X His tag® antibody [RMH01]

Recombinant|Lab Essentials

Sandwich ELISA - Anti-6X His tag® antibody [RMH01] (AB219465)

  • 0
  • 0
Primary Antibodies

AB76113

Anti-Prostate Specific Antigen antibody [EP1588Y]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostate Specific Antigen antibody [EP1588Y] (AB76113)

  • 0
  • 0
Primary Antibodies

AB133673

Anti-Alpha SNAP antibody [EPR7372]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha SNAP antibody [EPR7372] (AB133673)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
style
left-column

제품 세부 정보

The antibody solution should be gently mixed before use.
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The Molybdenum cofactor sulfurase (MOCOS) also known as MCS is an important enzyme in sulfur transfer for the activation of molybdenum cofactor. MOCOS weighs approximately 88 kDa and is found in a variety of tissues including liver and kidney. It plays a critical role in the biochemical process of activating the molybdenum cofactor which is essential for the proper function of certain enzymes.
Biological function summary

MOCOS contributes significantly to a sulfurase complex that includes other enzymes responsible for molybdenum cofactor biosynthesis and activation. It specifically introduces sulfur into the cofactor which is important for the functionality of molybdenum-dependent enzymes like xanthine dehydrogenase and aldehyde oxidase. MOCOS's activity impacts not just individual enzyme functions but whole biochemical pathways governed by these enzymes.

Pathways

MOCOS's biological function integrates into the purine degradation pathway and the aldehyde detoxification pathway. The enzyme works collaboratively with xanthine dehydrogenase in purine metabolism enabling the conversion of hypoxanthine to xanthine and subsequently to uric acid. In the aldehyde detoxification pathway MOCOS-associated enzymes such as aldehyde oxidase contribute to the breakdown of aromatic aldehydes and heterocyclic compounds playing a role in metabolizing pharmaceuticals and toxins.

MOCOS deficiencies relate to xanthinuria Type II characterized by an excessive accumulation of xanthine due to impaired xanthine dehydrogenase activity. Individuals with dysfunctional MOCOS can experience xanthine oxidation defects leading to potential renal complications due to stone formation. This relates closely to aldehyde oxidase whose reduced activity might impact drug metabolism and increase susceptibility to certain aldehyde-induced cellular damages.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Sulfurates the molybdenum cofactor (PubMed : 34356852). Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form (PubMed : 34356852). In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime (PubMed : 16973608).
See full target information MOCOS
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The Journal of biological chemistry 291:18514-24 PubMed27402836

2016

Collagen Accumulation in Osteosarcoma Cells lacking GLT25D1 Collagen Galactosyltransferase.

Applications

Unspecified application

Species

Unspecified reactive species

Stephan Baumann,Thierry Hennet
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com