AB236584

Anti-MPC2 antibody

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(5 제품이 사용된 논문 )

Rabbit Polyclonal MPC2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MPC2 aa 1-50.

대체 명칭 보기

BRP44, MPC2, Mitochondrial pyruvate carrier 2, Brain protein 44

2 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MPC2 antibody (AB236584)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MPC2 antibody (AB236584)

Paraffin-embedded human liver cancer tissue stained for MPC2 with ab236584 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MPC2 antibody (AB236584)

Paraffin-embedded human gastric cancer tissue stained for MPC2 with ab236584 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MPC2 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

O95563

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

Purification 관련 사항

Purity >95%.

보관 버퍼

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

MPC2 also known as Mitochondrial Pyruvate Carrier 2 is a protein that resides in the inner mitochondrial membrane. It functions as part of a carrier complex that imports pyruvate into mitochondria. The protein has a molecular mass of approximately 15 kDa. MPC2 is expressed in various tissues with high expression observed in metabolically active tissues like muscle and liver where it plays an important role in cellular energy metabolism.

Biological function summary

The function of MPC2 involves its role in forming the MPC (Mitochondrial Pyruvate Carrier) complex with MPC1. This complex is important for the transport of pyruvate into the mitochondria a necessary step in cellular respiration and energy production. The effective functioning of the MPC complex is essential for the proper execution of oxidative phosphorylation which ultimately leads to ATP generation.

Pathways

The mitochondrial pyruvate import facilitated by MPC2 plays an important role in the citric acid cycle (Krebs cycle) and the overall process of glycolysis. These pathways are central to cellular metabolism enabling cells to convert glucose into usable energy. Additionally MPC2 interacts indirectly with proteins involved in the electron transport chain as its activity influences the substrate availability for these downstream processes.

MPC2's function is linked to metabolic disorders and conditions. Defects or deficiencies in MPC2 function can lead to disruptions in energy homeostasis contributing to diseases such as diabetes and certain mitochondrial disorders. The protein shares connections with insulin signaling pathways as disruptions here can exacerbate glucose intolerance and insulin resistance.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Mediates the uptake of pyruvate into mitochondria to maintain the balance between glycolysis and oxidative phosphorylation (PubMed : 22628558, PubMed : 26253029, PubMed : 27317664, PubMed : 29472561, PubMed : 40044865, PubMed : 40101766, PubMed : 35278701). Plays an essential role in cellular metabolism (PubMed : 40044865, PubMed : 40101766).

See full target information MPC2

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제품이 사용된 논문 (5)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Discover oncology 16:1253 PubMed40601174

2025

Mitochondrial pyruvate carrier inhibits tumor growth by Bmi1 ubiquitination in renal cell carcinoma progression.

Applications

Unspecified application

Species

Unspecified reactive species

Dan Jian,Nana Hu,Rong He,Le He,He Xiao,Xingqiao Peng,Yang Peng,Yuxin Yang,Xiaoyan Dai,Dong Wang,Yan Feng,Nan Dai,Qian Chen

Biochemical genetics : PubMed40287899

2025

MPC2 Overexpression Drives Mitochondrial Oxidative Phosphorylation and Promotes Progression in Diffuse Large B-Cell Lymphoma.

Applications

Unspecified application

Species

Unspecified reactive species

Haoneng Wu,Qiuran Zhao,Xiaobo Ma,Ying Zhao,Qing Wang,Jinguang Bai,Songling Huang

OncoTargets and therapy 18:107-127 PubMed39867862

2025

Pan-Cancer Analysis Identifies YKT6 as a Prognostic and Immunotherapy Biomarker, with an Emphasis on Cervical Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jiamin Liu,Qiang Zhang,Ling He,Huangyu Hu,Yixuan Wang,Ping Xie

Neoplasia (New York, N.Y.) 41:100903 PubMed37148658

2023

Mitochondrial rewiring drives metabolic adaptation to NAD(H) shortage in triple negative breast cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Agata Sofia Assuncao Carreira,Silvia Ravera,Chiara Zucal,Natthakan Thongon,Irene Caffa,Cecilia Astigiano,Nadia Bertola,Arianna Buongiorno,Michela Roccuzzo,Alessandra Bisio,Barbara Pardini,Alessio Nencioni,Santina Bruzzone,Alessandro Provenzani

Journal of immunology research 2021:6618837 PubMed33791391

2021

Decreased Expression of MPC2 Contributes to Aerobic Glycolysis and Colorectal Cancer Proliferation by Activating mTOR Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Manzila Kuerbanjiang,Lei Gu,Chunjie Xu,Wen Ting Xu,Siyuan Wen,Hanbing Xue,Qing Xu

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-MPC2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MPC2 antibody (AB236584)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MPC2 antibody (AB236584)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (5)

Product promise