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AB97290

Anti-MPP2/DLG2 antibody

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(4 제품이 사용된 논문 )

Rabbit Polyclonal MPP2/DLG2 antibody. Suitable for WB and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MPP2 aa 100-450.
2 이미지
Western blot - Anti-MPP2/DLG2 antibody (AB97290)
  • WB

Supplier Data

Western blot - Anti-MPP2/DLG2 antibody (AB97290)

Samples were separated by 7.5% SDS-PAGE.

All lanes:

Western blot - Anti-MPP2/DLG2 antibody (ab97290) at 1/1000 dilution

All lanes:

A549 whole cell lysate at 30 µg

Predicted band size: 65 kDa

false

Western blot - Anti-MPP2/DLG2 antibody (AB97290)
  • WB

Supplier Data

Western blot - Anti-MPP2/DLG2 antibody (AB97290)

Samples were separated by 7.5% SDS-PAGE.

All lanes:

Western blot - Anti-MPP2/DLG2 antibody (ab97290) at 1/1000 dilution

All lanes:

Mouse brain tissue lysate at 50 µg

Predicted band size: 65 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human MPP2 aa 100-450. The exact immunogen used to generate this antibody is proprietary information.

Q14168

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대체품

Primary Antibodies

AB231634

Anti-MPP2/DLG2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-MPP2/DLG2 antibody (AB231634)

  • 0
  • 0

보완 제품

Primary Antibodies

AB198499

Anti-GRID2 antibody [EPR15422] - N-terminal

RabMAb|Recombinant

Western blot - Anti-GRID2 antibody [EPR15422] - N-terminal (AB198499)

  • 0
  • 0
Primary Antibodies

AB240636

Anti-Ctip2 antibody [EPR23120-25]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Flow Cytometry (Intracellular) - Anti-Ctip2 antibody [EPR23120-25] (AB240636)

  • 5
  • 1
Primary Antibodies

AB92446

Anti-SATB2 antibody [EPNCIR130A]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SATB2 antibody [EPNCIR130A] (AB92446)

  • 5
  • 10
Primary Antibodies

AB183032

Anti-TBR1 antibody [EPR8138(2)]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Frozen sections) - Anti-TBR1 antibody [EPR8138(2)] (AB183032)

  • 5
  • 6
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The MPP2 also known as DLG2 (Discs Large Homolog 2) is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. It plays a role in maintaining cell polarity and organizing signal complexes at cell junctions. This protein has a mass of approximately 85 kDa. MPP2/DLG2 expresses mainly in the brain particularly in neuronal cells where it contributes to synaptic transmission and plasticity.
Biological function summary

The DLG2 protein acts as a scaffolding protein that organizes other proteins within the synaptic membrane at excitatory synapses. It is part of the heteromeric complex that includes other synaptic proteins facilitating interactions between NMDA receptors and various signaling molecules. By stabilizing these protein interactions DLG2 influences synaptic strength and cellular communication pathways.

Pathways

DLG2 is involved in the regulation of synaptic plasticity which plays an important role in learning and memory. It participates in the NMDA receptor signaling pathway interacting with proteins like PSD-95 which is important for synapse maturation and plasticity. Additionally DLG2 is linked to the MAPK signaling pathway which impacts cell growth division and differentiation.

DLG2 has associations with neurological disorders such as schizophrenia and intellectual disabilities. Its interaction with proteins like SHANK3 which are implicated in neuropsychiatric conditions suggests that dysregulation of DLG2 can lead to abnormal synaptic signaling linked to these disorders. Understanding DLG2's function and connections is important for exploring therapeutic targets in these brain disorders.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity). Seems to negatively regulate SRC function in epithelial cells (PubMed : 19665017).
See full target information MPP2

대체 명칭 보기

DLG2, MPP2, MAGUK p55 subfamily member 2, Discs large homolog 2, Protein MPP2
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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

JCI insight 9: PubMed38889014

2024

Chronic pharmacologic manipulation of dopamine transmission ameliorates metabolic disturbance in Trappc9-linked brain developmental syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Li,Muhammad Usman,Ellen Sapp,Yuting Ke,Zejian Wang,Adel Boudi,Marian DiFiglia,Xueyi Li

PLoS biology 20:e3001503 PubMed35312684

2022

The synaptic scaffold protein MPP2 interacts with GABAA receptors at the periphery of the postsynaptic density of glutamatergic synapses.

Applications

Unspecified application

Species

Unspecified reactive species

Bettina Schmerl,Niclas Gimber,Benno Kuropka,Alexander Stumpf,Jakob Rentsch,Stella-Amrei Kunde,Judith von Sivers,Helge Ewers,Dietmar Schmitz,Christian Freund,Jan Schmoranzer,Nils Rademacher,Sarah A Shoichet

Bioscience reports 39: PubMed30808715

2019

gene suppresses intracranial aneurysm formation and rupture through inhibiting the NF-κB signaling pathway mediated inflammatory response.

Applications

Unspecified application

Species

Unspecified reactive species

Xian-Liang Lai,Zhi-Feng Deng,Xin-Gen Zhu,Zhi-Hua Chen

Scientific reports 6:35283 PubMed27756895

2016

MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density.

Applications

WB, ICC/IF

Species

Unspecified reactive species, Unspecified reactive species

Nils Rademacher,Bettina Schmerl,Jennifer A Lardong,Markus C Wahl,Sarah A Shoichet
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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