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AB140863

Anti-MRGX3 antibody - Extracellular domain

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(1 출판물)

Rabbit Polyclonal MRGX3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MRGPRX3.

대체 명칭 보기

MRGX3, SNSR1, SNSR2, MRGPRX3, Mas-related G-protein coupled receptor member X3, Sensory neuron-specific G-protein coupled receptor 1/2

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRGX3 antibody - Extracellular domain (AB140863)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRGX3 antibody - Extracellular domain (AB140863)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human Brain Cerebellum (Purkinje Neurons) tissue labelling MRGX3 with ab140863 at 21 μg/ml.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human MRGPRX3. The exact immunogen used to generate this antibody is proprietary information.

Q96LB0

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except MRGPRX4 (59%), LRRK2 (53%), CACNB4 (47%).

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보완 제품

Primary Antibodies

AB140486

Anti-5HT1D Receptor antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-5HT1D Receptor antibody (AB140486)

  • 1
  • 2
Primary Antibodies

AB122514

Anti-GRIP1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GRIP1 antibody (AB122514)

  • 0
  • 0
Primary Antibodies

AB230778

Anti-5HT1F Receptor antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-5HT1F Receptor antibody (AB230778)

  • 0
  • 0
Primary Antibodies

AB140524

Anti-5HT2A Receptor antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-5HT2A Receptor antibody - C-terminal (AB140524)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "21 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

MRGX3 also known as MAS-related G protein-coupled receptor member X3 is a G protein-coupled receptor primarily involved in cell signaling. It has a molecular mass of approximately 45 kDa. MRGX3 predominantly expresses in the dorsal root ganglia and a subset of sensory neurons. As a receptor MRGX3 binds to specific ligands and activates intracellular G proteins leading to downstream signaling cascades.
Biological function summary

The receptor influences pain sensation and modulation pathways. It does this by interacting with various ligands to modulate neuronal excitability. MRGX3 does not appear to form part of a larger receptor complex but acts within the framework of peripheral nervous system signaling. Its presence in sensory neurons suggests an essential role in responding to environmental stimuli and possibly modulating inflammatory responses.

Pathways

MRGX3 takes part in the pain regulation and sensory perception pathways. It interacts with other proteins like TRPV1 which is involved in the heat pain pathway and modulates pain sensation. While MRGX3's precise place in the signaling pathway is not entirely understood it is clear that it influences signal transduction through G protein-dependent mechanisms relevant for pain and sensory functions.

MRGX3 connects to neuropathic pain and chronic inflammation-related disorders. Alterations or dysregulation of MRGX3 function can contribute to exacerbated pain states. Studies suggest an interaction with proteins such as GPR183 linking MRGX3 to the development of chronic pain disorders though research is ongoing to fully elucidate these connections.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).
See full target information MRGPRX3
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

PloS one 10:e0117581 PubMed25807145

2015

Discovery of molecular markers to discriminate corneal endothelial cells in the human body.

Applications

Unspecified application

Species

Unspecified reactive species

Masahito Yoshihara,Hiroko Ohmiya,Susumu Hara,Satoshi Kawasaki,Yoshihide Hayashizaki,Masayoshi Itoh,Hideya Kawaji,Motokazu Tsujikawa,Kohji Nishida
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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