AB67844

Anti-MRPL18 antibody

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(3 제품이 사용된 논문 )

Mouse Polyclonal MRPL18 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MRPL18.

1 이미지

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Western blot - Anti-MRPL18 antibody (AB67844)

All lanes:

Western blot - Anti-MRPL18 antibody (ab67844) at 1/500 dilution

All lanes:

Human liver tissue lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate secondary antibody at 1/2500 dilution

Predicted band size: 21 kDa

Observed band size: 18 kDa

true

주요 정보

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

applications

Immunogen

Recombinant Full Length Protein corresponding to Human MRPL18.

Q9H0U6

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.4 Constituents: PBS

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

MRPL18 also known as mitochondrial ribosomal protein L18 is an integral component of the mitochondrial ribosome. This protein has a molecular mass of about 21 kDa. It plays a mechanical role in the translation of mitochondrial mRNA aiding the assembly of protein synthesis machinery. MRPL18 finds expression predominantly in tissues with high energy requirements such as heart and brain.

Biological function summary

MRPL18 is essential for mitochondrial protein biosynthesis. It forms part of the 39S subunit of the mitochondrial ribosome implicating its role in the production of polypeptides catalyzed by mitochondrial DNA. By facilitating efficient translation of genetic material into functional proteins MRPL18 collaborates with other ribosomal proteins and rRNA to maintain mitochondrial function.

Pathways

MRPL18 significantly contributes to oxidative phosphorylation and energy generation pathways. It supports these pathways by translating essential components of the electron transport chain. Closely related proteins like MRPL49 and MRPS16 also participate in these pathways together ensuring effective energy transduction within the cell.

MRPL18 shows associations with mitochondrial diseases such as mitochondrial encephalomyopathy. Impaired function or mutations in MRPL18 can disrupt mitochondrial protein synthesis leading to defective energy metabolism. The target's relationship with proteins like MRPS22 highlights its involvement in disease mechanisms affecting cellular energy homeostasis.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA.

See full target information MRPL18

대체 명칭 보기

HSPC071, MRPL18, Large ribosomal subunit protein uL18m, L18mt, MRP-L18

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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Science immunology 7:eabq4531 PubMed36399538

2022

mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand .

Applications

Unspecified application

Species

Unspecified reactive species

Leslie Naesens,Santoshi Muppala,Dhiraj Acharya,Josephine Nemegeer,Delfien Bogaert,Jung-Hyun Lee,Katrien Staes,Veronique Debacker,Pieter De Bleser,Marieke De Bruyne,Elfride De Baere,Michiel van Gent,GuanQun Liu,Bart N Lambrecht,Jens Staal,Tessa Kerre,Rudi Beyaert,Jonathan Maelfait,Simon J Tavernier,Michaela U Gack,Filomeen Haerynck

Nature immunology 19:53-62 PubMed29180807

2017

Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Jessica J Chiang,Konstantin M J Sparrer,Michiel van Gent,Charlotte Lässig,Teng Huang,Nikolaus Osterrieder,Karl-Peter Hopfner,Michaela U Gack

Genes & development 25:1289-305 PubMed21685364

2011

Biological significance of 5S rRNA import into human mitochondria: role of ribosomal protein MRP-L18.

Applications

Species

Human

Alexandre Smirnov,Nina Entelis,Robert P Martin,Ivan Tarassov

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-MRPL18 antibody

Western blot - Anti-MRPL18 antibody (AB67844)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (3)

Product promise