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AB151055

Anti-MRPL34 antibody

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(1 출판물)

Rabbit Polyclonal MRPL34 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MRPL34 aa 1 to C-terminus.

대체 명칭 보기

Large ribosomal subunit protein bL34m, L34mt, MRP-L34, MRPL34

3 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPL34 antibody (AB151055)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPL34 antibody (AB151055)

Immunohistochemical analysis of paraffin-embedded Human testis tissue labeling MRPL34 with ab151055 at 1/200 dilution.

Immunocytochemistry/ Immunofluorescence - Anti-MRPL34 antibody (AB151055)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-MRPL34 antibody (AB151055)

Immunofluorescent staining of human cell line U-2 OS shows positivity in nucleus, vesicles & actin filaments.

Western blot - Anti-MRPL34 antibody (AB151055)
  • WB

Unknown

Western blot - Anti-MRPL34 antibody (AB151055)

All lanes:

Western blot - Anti-MRPL34 antibody (ab151055) at 1/250 dilution

Lane 1:

RT-4 cell lysate

Lane 2:

U-251 MG cell lysate

Lane 3:

Human Plasma lysate

Lane 4:

Human Liver lysate

Lane 5:

Human Tonsil lysate

Predicted band size: 10 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human MRPL34 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9BQ48

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보완 제품

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB224467

Anti-MRPL37 antibody

Immunocytochemistry/ Immunofluorescence - Anti-MRPL37 antibody (AB224467)

  • 0
  • 0
Primary Antibodies

AB184772

Anti-URG11 antibody

Immunocytochemistry/ Immunofluorescence - Anti-URG11 antibody (AB184772)

  • 4
  • 2
Primary Antibodies

AB184725

Anti-VWA8 antibody - C-terminal

Immunocytochemistry/ Immunofluorescence - Anti-VWA8 antibody - C-terminal (AB184725)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/250 - 1/500", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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제품 세부 정보

The antibody solution should be gently mixed before use.
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

MRPL34 also known as 39S ribosomal protein L34 mitochondrial is a component of the mitochondrial ribosome large subunit. It has a molecular mass of approximately 15 kDa. MRPL34 plays a role in mitochondrial protein synthesis and is widely expressed in tissues with high energy demands such as the heart skeletal muscles and brain. The mitochondrial ribosomes differ from cytoplasmic ribosomes in protein-to-rRNA ratio and are essential for proper mitochondrial function.
Biological function summary

MRPL34 is part of the large subunit of the mitochondrial ribosome which assembles with the small subunit to translate mitochondrial-encoded proteins essential for the oxidative phosphorylation system. Within the mitochondrial ribosome which is composed of roughly 50 distinct proteins and 2 ribosomal RNA molecules MRPL34 contributes to the formation and stabilization of the ribosomal RNA core structure. Its involvement in mitochondrial protein translation directly affects cellular energy metabolism and overall mitochondrial function.

Pathways

MRPL34 contributes to the mitochondrial translation pathway an essential part of maintaining the electron transport chain by facilitating the synthesis of core components required for oxidative phosphorylation. Key proteins involved in these processes include cytochrome c oxidase and ATP synthase essential for energy production. MRPL34 ensures the proper assembly of these complexes by aiding the accurate translation of mitochondrial genome-encoded proteins.

Mutations or malfunction of MRPL34 can lead to diseases such as mitochondrial myopathy and neurodegenerative disorders like Parkinson's disease. Abnormal function of MRPL34 disrupts mitochondrial protein production affecting cellular energy levels and function. It can also influence the activity of proteins such as cytochrome c further impacting oxidative stress response and cell survival in tissues with high metabolic activity.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

See full target information MRPL34
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Redox report : communications in free radical research 29:2354625 PubMed38794801

2024

TOM5 regulates the mitochondrial membrane potential of alveolar epithelial cells in organizing pneumonia.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Qian,Xiao Li,Xinyu Li,Xijie Zhang,Qi Yuan,Zhengxia Wang,Minghun Zhang,Mao Huang,Ningfei Ji
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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