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AB121821

Anti-MRPL41 antibody

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(3 제품이 사용된 논문 )

Rabbit Polyclonal MRPL41 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MRPL41 aa 50 to C-terminus.

대체 명칭 보기

BMRP, MRPL27, RPML27, PIG3, MRPL41, Large ribosomal subunit protein mL41, Bcl-2-interacting mitochondrial ribosomal protein L41, Cell proliferation-inducing gene 3 protein, MRP-L27 homolog, L41mt, MRP-L41

3 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPL41 antibody (AB121821)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPL41 antibody (AB121821)

ab121821, at 1/300 dilution, staining MRPL41 in paraffin-embedded Human rectum tissue by Immunohistochemistry.

Immunocytochemistry/ Immunofluorescence - Anti-MRPL41 antibody (AB121821)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-MRPL41 antibody (AB121821)

ab121821, at 4µg/ml, staining MRPL41 in U-251MG cells by Immunofluorescence. Antibody staining is shown in green.

Western blot - Anti-MRPL41 antibody (AB121821)
  • WB

Unknown

Western blot - Anti-MRPL41 antibody (AB121821)

All lanes:

Western blot - Anti-MRPL41 antibody (ab121821) at 1/250 dilution

Lane 1:

RT-4 cell lysate

Lane 2:

U-251 MG cell lysate

Lane 3:

Human Plasma lysate

Lane 4:

Human Liver lysate

Lane 5:

Human Tonsil lysate

Predicted band size: 15 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MRPL41 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8IXM3

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보완 제품

Primary Antibodies

AB180498

Anti-NHP2 antibody [EPR12404]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NHP2 antibody [EPR12404] (AB180498)

  • 5
  • 1
Primary Antibodies

AB96819

Anti-PIG3 antibody

Immunocytochemistry/ Immunofluorescence - Anti-PIG3 antibody (AB96819)

  • 0
  • 0
Primary Antibodies

AB129022

Anti-ALDH3A1 antibody [EPR7406]

RabMAb|Recombinant

Western blot - Anti-ALDH3A1 antibody [EPR7406] (AB129022)

  • 0
  • 0
Proteins & Peptides

AB95857

Recombinant Human PIG3 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human PIG3 protein (His tag N-Terminus) (AB95857)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

MRPL41 also known as mitochondrial ribosomal protein L41 plays an important role in protein synthesis within the mitochondria. This protein is a component of the large 39S subunit of mitochondrial ribosome with a molecular mass estimated around 25 kDa. It is expressed primarily in mitochondria across various tissues implying a wide-ranging function associated with cellular energy production and metabolism.
Biological function summary

MRPL41 interacts in mitochondrial ribosome assembly where it helps in the production of proteins necessary for mitochondrial function. It is a segment of the mitochondrial ribosome working alongside other ribosomal proteins in a specialized complex. These proteins ensure that the mitochondria can synthesize their own proteins which are vital for the organelle's energy-converting activities. MRPL41 thereby is instrumental in maintaining the integrity of the mitochondrial protein synthesis machinery.

Pathways

MRPL41 is embedded within the mitochondrial translation and oxidative phosphorylation pathways which are essential for cellular energy supply. This protein forms connections with other mitochondrial ribosomal proteins such as MRPL2 contributing to the proper function of the electron transport chain. Disruption in these pathways could lead to significant cellular dysfunctions due to mitochondrial malfunction.

MRPL41 is associated with mitochondrial diseases which can result from failures in mitochondrial protein synthesis. These disorders often present as metabolic issues or multisystemic anomalies. MRPL41 has connections to proteins like MRPS22 which is also involved in the mitochondrial ribosome and is implicated in similar disorders. Understanding MRPL41's role gives insights into potential therapeutic targets for mitochondrial-related diseases.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Component of the mitochondrial ribosome large subunit (PubMed : 25278503, PubMed : 25838379, PubMed : 28892042, PubMed : 35177605). Also involved in apoptosis and cell cycle (PubMed : 16024796, PubMed : 16256947). Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (PubMed : 16024796).
See full target information MRPL41
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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in genetics 13:1097234 PubMed36704343

2023

A novel 9-gene signature for the prediction of postoperative recurrence in stage II/III colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Cheng Xin,Yi Lai,Liqiang Ji,Ye Wang,Shihao Li,Liqiang Hao,Wei Zhang,Ronggui Meng,Jun Xu,Yonggang Hong,Zheng Lou

Journal of molecular endocrinology 68:63-76 PubMed34752415

2021

Non-cell autonomous mechanisms control mitochondrial gene dysregulation in polycystic ovary syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Alba Moreno-Asso,Ali Altıntaş,Luke C McIlvenna,Rhiannon K Patten,Javier Botella,Andrew J McAinch,Raymond J Rodgers,Romain Barrès,Nigel K Stepto

Journal of cellular and molecular medicine : PubMed32583631

2020

LncRNA FAM83H-AS1 promotes oesophageal squamous cell carcinoma progression via miR-10a-5p/Girdin axis.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Feng,Gaoyan Wang,Xiaoliang Liang,Zheng Wu,Xinchen Wang,Zhiming Dong,Yanli Guo,Supeng Shen,Jia Liang,Wei Guo
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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