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AB235828

Anti-MRPL51 antibody

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(3 제품이 사용된 논문 )

Rabbit Polyclonal MRPL51 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MRPL51.

대체 명칭 보기

MRP64, CDA09, HSPC241, MRPL51, Large ribosomal subunit protein mL51, bMRP-64, L51mt, MRP-L51, bMRP64

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPL51 antibody (AB235828)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPL51 antibody (AB235828)

Paraffin-embedded human small intestine tissue stained for MRPL51 using ab235828 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human MRPL51.

Q4U2R6

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

MRPL51 also known as mitochondrial ribosomal protein L51 is an integral component of the mitochondrial ribosome. It is involved in protein synthesis within the mitochondria. MRPL51 has a molecular mass of about 14.3 kDa. The protein is expressed in a wide range of tissues reflecting its fundamental role in mitochondrial function across different cell types. It localizes predominantly within the mitochondria indicating its direct involvement in mitochondrial protein synthesis.
Biological function summary

MRPL51 functions as part of the large subunit of the mitochondrial ribosome which is essential for the translation of proteins encoded by mitochondrial DNA. The protein is a component of a much larger ribosomal complex that assembles mRNA translation machinery specific to mitochondria. This complex plays a critical role in maintaining the functionality of mitochondria by ensuring the continuous production of proteins necessary for the electron transport chain and other mitochondrial processes.

Pathways

The ribosomal activity of MRPL51 connects directly to the oxidative phosphorylation pathway one of the most important for energy production within cells. The protein is associated with the synthesis of components essential for ATP generation. MRPL51 also relates to the mitochondrial translation pathway where it interacts with other ribosomal proteins to facilitate protein synthesis. Proteins like POLG the mitochondrial DNA polymerase and other subunits of the ribosome are also involved in these pathways illustrating an integrated role in cellular bioenergetics.

MRPL51 and its function are significant in conditions such as mitochondrial myopathy and neurodegenerative diseases. Defects in mitochondrial protein synthesis can contribute to these disorders as they result in impaired energy production. MRPL51's role in this context ties it to disorders where mitochondrial dysfunction is a factor. Additionally proteins involved in mitochondrial DNA maintenance and translation such as TFAM and TFB2M highlight the broader network of interaction that influences disease progression and manifestation.

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Autophagy 19:1745-1763 PubMed36449354

2022

The effector Vm1G-1794 protects the aggregated MdEF-Tu from autophagic degradation to promote infection in apple.

Applications

Unspecified application

Species

Unspecified reactive species

Runmin Che,Changhai Liu,Qi Wang,Wenyan Tu,Ping Wang,Chao Li,Xiaoqing Gong,Ke Mao,Hao Feng,Lili Huang,Pengmin Li,Fengwang Ma

Biomedicines 10: PubMed35625704

2022

Arsenic Activates the ER Stress-Associated Unfolded Protein Response via the Activating Transcription Factor 6 in Human Bronchial Epithelial Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Priya Wadgaonkar,Zhuoyue Bi,Junmei Wan,Yao Fu,Qian Zhang,Bandar Almutairy,Wenxuan Zhang,Yiran Qiu,Chitra Thakur,Maik Hüttemann,Fei Chen

Cell reports 29:1728-1738.e9 PubMed31693908

2019

MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition.

Applications

Unspecified application

Species

Unspecified reactive species

Jakob D Busch,Miriam Cipullo,Ilian Atanassov,Ana Bratic,Eduardo Silva Ramos,Thomas Schöndorf,Xinping Li,Sarah F Pearce,Dusanka Milenkovic,Joanna Rorbach,Nils-Göran Larsson
제품이 사용된 논문 모두 보기

Product promise

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