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AB243821

Anti-MRPL51 antibody

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Rabbit Polyclonal MRPL51 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MRPL51 aa 50 to C-terminus.

대체 명칭 보기

MRP64, CDA09, HSPC241, MRPL51, Large ribosomal subunit protein mL51, bMRP-64, L51mt, MRP-L51, bMRP64

3 이미지
Immunocytochemistry/ Immunofluorescence - Anti-MRPL51 antibody (AB243821)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-MRPL51 antibody (AB243821)

PFA fixed, Triton X-100 permeabilized A431 (Human epidermoid carcinoma cell line) cells labeling MRPL51 using ab243821 at 4 μg/ml (green) in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPL51 antibody (AB243821)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPL51 antibody (AB243821)

Formalin-fixed, paraffin-embedded human duodenum tissue stained for MRPL51 with ab243821 at a 1/50 dilution in immunohistochemical analysis.

Western blot - Anti-MRPL51 antibody (AB243821)
  • WB

Supplier Data

Western blot - Anti-MRPL51 antibody (AB243821)

All lanes:

Western blot - Anti-MRPL51 antibody (ab243821) at 0.4 µg/mL

Lane 1:

RT4 (Human urinary bladder cancer cell line) cell lysate

Lane 2:

U-251 MG (Human brain glioma cell line) cell lysate

Predicted band size: 15 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human MRPL51 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q4U2R6

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대체품

Primary Antibodies

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Anti-MRPL51 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPL51 antibody (AB235828)

  • 0
  • 0

보완 제품

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MiTF antibody [EPR26363-10] (AB303530)

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Primary Antibodies

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Primary Antibodies

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRP1 antibody [EPR21960] (AB235447)

  • 5
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

MRPL51 also known as mitochondrial ribosomal protein L51 is an integral component of the mitochondrial ribosome. It is involved in protein synthesis within the mitochondria. MRPL51 has a molecular mass of about 14.3 kDa. The protein is expressed in a wide range of tissues reflecting its fundamental role in mitochondrial function across different cell types. It localizes predominantly within the mitochondria indicating its direct involvement in mitochondrial protein synthesis.
Biological function summary

MRPL51 functions as part of the large subunit of the mitochondrial ribosome which is essential for the translation of proteins encoded by mitochondrial DNA. The protein is a component of a much larger ribosomal complex that assembles mRNA translation machinery specific to mitochondria. This complex plays a critical role in maintaining the functionality of mitochondria by ensuring the continuous production of proteins necessary for the electron transport chain and other mitochondrial processes.

Pathways

The ribosomal activity of MRPL51 connects directly to the oxidative phosphorylation pathway one of the most important for energy production within cells. The protein is associated with the synthesis of components essential for ATP generation. MRPL51 also relates to the mitochondrial translation pathway where it interacts with other ribosomal proteins to facilitate protein synthesis. Proteins like POLG the mitochondrial DNA polymerase and other subunits of the ribosome are also involved in these pathways illustrating an integrated role in cellular bioenergetics.

MRPL51 and its function are significant in conditions such as mitochondrial myopathy and neurodegenerative diseases. Defects in mitochondrial protein synthesis can contribute to these disorders as they result in impaired energy production. MRPL51's role in this context ties it to disorders where mitochondrial dysfunction is a factor. Additionally proteins involved in mitochondrial DNA maintenance and translation such as TFAM and TFB2M highlight the broader network of interaction that influences disease progression and manifestation.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

See full target information MRPL51
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Product promise

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