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AB121718

Anti-MSL1 antibody

5

(1 리뷰)

|

(1 출판물)

Rabbit Polyclonal MSL1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MSL1 aa 200 to C-terminus.

대체 명칭 보기

MSL1L1, MSL1, Male-specific lethal 1 homolog, MSL-1, Male-specific lethal 1-like 1, Male-specific lethal-1 homolog 1, MSL1-like 1

2 이미지
Immunocytochemistry/ Immunofluorescence - Anti-MSL1 antibody (AB121718)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-MSL1 antibody (AB121718)

ab121718 at 4 μg/ml staining MSL1v1 (green) in PFA/Triton X-100 fixed/permeabilized A431 cells by Immunofluorescence.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MSL1 antibody (AB121718)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MSL1 antibody (AB121718)

ab121718 at 1/400 dilution staining MSL1v1 in Paraffin-embedded Human Prostate tissue by Immunohistochemistry.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MSL1 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q68DK7

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보완 제품

Primary Antibodies

AB92446

Anti-SATB2 antibody [EPNCIR130A]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SATB2 antibody [EPNCIR130A] (AB92446)

  • 5
  • 10
Primary Antibodies

AB64090

Anti-Cytokeratin 20 antibody [SP33]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 20 antibody [SP33] (AB64090)

  • 5
  • 1
Primary Antibodies

AB205606

Anti-DDDDK tag (Binds to FLAG® tag sequence) antibody [EPR20018-251]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Western blot - Anti-DDDDK tag (Binds to FLAG® tag sequence) antibody [EPR20018-251] (AB205606)

  • 5
  • 2
Primary Antibodies

AB33985

Anti-COX IV antibody [mAbcam33985] - Mitochondrial Marker

Lab Essentials

Western blot - Anti-COX IV antibody [mAbcam33985] - Mitochondrial Marker (AB33985)

  • 5
  • 25
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

MSL1 or Male-Specific Lethal 1 functions mechanically as an important component of the MSL complex that engages in gene regulation activities. It has a molecular mass of approximately 62 kDa. MSL1 expresses in diverse tissues including the brain liver and muscle. It plays a critical role in dosage compensation contributing to equalizing gene expression levels between sexes in species like Drosophila.
Biological function summary

MSL1 participates in the assembly of the MSL complex. This multi-protein complex facilitates histone H4 lysine 16 acetylation which activates transcription. MSL1 specifically assists in recruiting the acetyltransferase MOF to target sites on the X chromosome. The expression level and activity of MSL1 are tightly regulated to ensure proper chromosomal balance in the organism. Its activity is not limited to dosage compensation but also influences other chromatin remodeling processes.

Pathways

MSL1 plays significant roles in chromatin modification pathways participating in transcriptional regulation actively. The protein aligns closely with MOF in these pathways forming a duo that heavily influences acetylation across chromatin landscapes. In addition to histone modification MSL1 connections extend to gene expression pathways responding to various cellular stimuli interfacing with proteins like MSL2 and MSL3 to regulate gene activation machinery.

MSL1 has associations with certain cancers including breast cancer and leukemia. The protein's dysregulation can skew chromatin remodeling leading to abnormal gene expression profiles commonly seen in tumorigenesis. MSL1 partners with other proteins like MOF impacting the transcriptional regulatory networks often targeted in cancer therapies. Understanding MSL1's role allows for targeted approaches in developing therapeutic strategies for these diseases.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed : 16227571, PubMed : 16543150, PubMed : 33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed : 33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed : 22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed : 21726816, PubMed : 30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed : 21726816).
See full target information MSL1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Bone research 11:1 PubMed36588108

2023

A novel molecular classification method for osteosarcoma based on tumor cell differentiation trajectories.

Applications

Unspecified application

Species

Unspecified reactive species

Hao Zhang,Ting Wang,Haiyi Gong,Runyi Jiang,Wang Zhou,Haitao Sun,Runzhi Huang,Yao Wang,Zhipeng Wu,Wei Xu,Zhenxi Li,Quan Huang,Xiaopan Cai,Zaijun Lin,Jinbo Hu,Qi Jia,Chen Ye,Haifeng Wei,Jianru Xiao
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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