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AB244396

Anti-MSP/MST1 antibody

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(1 출판물)

Rabbit Polyclonal MSP/MST1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MST1 aa 400-500.

대체 명칭 보기

D3F15S2, DNF15S2, HGFL, MST1, Hepatocyte growth factor-like protein, Macrophage stimulatory protein, Macrophage-stimulating protein, MSP

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MSP/MST1 antibody (AB244396)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MSP/MST1 antibody (AB244396)

Paraffin-embedded human liver tissue stained for MSP/MST1 using ab244396 at 1/50 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MST1 aa 400-500. The exact immunogen used to generate this antibody is proprietary information.

P26927

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대체품

Primary Antibodies

AB76822

Anti-MSP/MST1 antibody

Western blot - Anti-MSP/MST1 antibody (AB76822)

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Primary Antibodies

AB231138

Anti-MSP/MST1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MSP/MST1 antibody (AB231138)

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Primary Antibodies

AB245826

Anti-MSP/MST1 antibody [EPR22184-180] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-MSP/MST1 antibody [EPR22184-180] - BSA and Azide free (AB245826)

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Primary Antibodies

AB245190

Anti-MSP/MST1 antibody [EPR22184-180]

RabMAb|Recombinant|KO Validated

Western blot - Anti-MSP/MST1 antibody [EPR22184-180] (AB245190)

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보완 제품

Assay Kits

AB256390

Mouse MSP ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Mouse MSP ELISA Kit (AB256390)

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Primary Antibodies

AB231138

Anti-MSP/MST1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MSP/MST1 antibody (AB231138)

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Primary Antibodies

AB243656

Anti-LATS1/WARTS antibody [EPR23057-116]

RabMAb|Recombinant|KO Validated|20ul selling size

Flow Cytometry (Intracellular) - Anti-LATS1/WARTS antibody [EPR23057-116] (AB243656)

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Primary Antibodies

AB172730

Rabbit IgG, monoclonal [EPR25A] - Isotype Control

RabMAb|Advanced Validation|Recombinant

Flow Cytometry - Rabbit IgG, monoclonal [EPR25A] - Isotype Control (AB172730)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

MSP/MST1 also known as macrophage stimulating protein is a serine protease family protein with a molecular mass of approximately 80 kDa. It expresses in various tissues with significant presence in liver tissue. MST1 is a precursor protein that undergoes proteolytic cleavage to become its active form. MSP protein plays an important role in signaling processes acting as a ligand for the RON receptor tyrosine kinase triggering downstream effects in various cellular systems.
Biological function summary

MSP protein contributes to numerous cellular events including migration differentiation and survival. It forms a complex with the RON receptor facilitating cell signaling cascades that influence these processes. MSP is key in the regulation of immune responses and tissue remodeling which makes it significant in inflammation and wound healing contexts. It influences macrophage activity promoting their ability to clear pathogens and repair tissues.

Pathways

MSP protein is integral to the HGF/MET signaling pathway and the related MSP/RON pathway. These pathways are involved in cellular growth motility and morphogenesis with a notable impact on epithelial cellular dynamics. MST1 through its interaction with RON influences c-Met and related pathways that intertwine with cell cycle regulation. The crosstalk with hepatocyte growth factor (HGF) can further elucidate the sophisticated regulation of cellular functions where MSP plays a role.

MSP protein has been implicated in cancer progression and inflammatory diseases. It associates closely with the progression of certain carcinomas through its interaction with the RON receptor influencing tumor proliferation and metastasis. Additionally the dysregulation of MSP is associated with chronic inflammatory conditions linking it to key pathway proteins such as HGF. The therapeutic targeting of MSP might offer insights into anticancer and anti-inflammatory treatment strategies.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

See full target information MST1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

International journal of molecular medicine 47:643-658 PubMed33416146

2021

Regulatory role of DEPTOR‑mediated cellular autophagy and mitochondrial reactive oxygen species in angiogenesis in multiple myeloma.

Applications

Unspecified application

Species

Unspecified reactive species

Jizhen Wang,Junmin Chen,Dongbiao Qiu,Zhiyong Zeng
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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