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AB243587

Anti-MTA3 antibody

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Rabbit Polyclonal MTA3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MTA3 aa 400 to C-terminus.

대체 명칭 보기

KIAA1266, MTA3, Metastasis-associated protein MTA3

2 이미지
Immunocytochemistry/ Immunofluorescence - Anti-MTA3 antibody (AB243587)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-MTA3 antibody (AB243587)

PFA-fixed, Triton X-100 permeabilized U-251 MG (human brain glioma cell line) cells stained for MTA3 (green) using ab243587 at 4 μg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MTA3 antibody (AB243587)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MTA3 antibody (AB243587)

Formalin-fixed, paraffin-embedded human colon tissue stained for MTA3 using ab243587 at 1/200 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human MTA3 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9BTC8

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대체품

Primary Antibodies

AB176346

Anti-MTA3 antibody [EPR12777(B)]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-MTA3 antibody [EPR12777(B)] (AB176346)

  • 0
  • 0
Primary Antibodies

AB87275

Anti-MTA3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MTA3 antibody (AB87275)

  • 5
  • 3

보완 제품

Primary Antibodies

AB171073

Anti-MTA2/PID antibody [EPR8537(2)]

RabMAb|Recombinant|Trial Size

Flow Cytometry (Intracellular) - Anti-MTA2/PID antibody [EPR8537(2)] (AB171073)

  • 0
  • 0
Primary Antibodies

AB79416

Anti-RBBP4 antibody [EPR3411] - ChIP Grade

RabMAb|Advanced Validation|Recombinant

Flow Cytometry (Intracellular) - Anti-RBBP4 antibody [EPR3411] - ChIP Grade (AB79416)

  • 0
  • 0
Primary Antibodies

AB70469

Anti-CHD4 antibody [3F2/4]

BOND RX™ Validated|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHD4 antibody [3F2/4] (AB70469)

  • 5
  • 8
Primary Antibodies

AB7028

Anti-HDAC1 antibody - Nuclear Loading Control

Western blot - Anti-HDAC1 antibody - Nuclear Loading Control (AB7028)

  • 4
  • 24
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The MTA3 protein also known as Metastasis-Associated Protein 3 is a member of the MTA family and has a molecular mass of approximately 53 kDa. MTA3 localizes in the nucleus and shows expression in various tissues including breast tissue and the immune system. It functions as a transcriptional corepressor particularly influencing E-cadherin repression by being part of the nucleosome remodeling and histone deacetylase (NuRD) complex.
Biological function summary

Activities involving gene expression regulation occur through interactions with other chromatin-associated molecules. MTA3 participates as a component of the NuRD complex which also includes Mi2 and HDAC1 that is critical in chromatin remodeling and transcriptional repression. Through MTA3's involvement the complex influences cell proliferation differentiation and epithelial-mesenchymal transition (EMT).

Pathways

MTA3 is particularly significant in the EMT pathway affecting cell migration and invasion capacities. It interacts with proteins such as TWIST and ZEB1 which are associated with EMT. Additionally MTA3 plays a role in the Notch signaling pathway where it helps in maintaining proper cell lineage differentiation by modulating transcription factors through deacetylation processes.

Altered MTA3 expression is seen in breast cancer and has a link to its progression. It connects closely with E-cadherin which serves as a marker for EMT and cancer metastasis. MTA3's involvement in histone modification pathways also correlates with altered gene expression seen in various autoimmune disorders making it a possible point of interest for therapeutic research and interventions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed : 12705869, PubMed : 16428440, PubMed : 28977666). Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (PubMed : 12705869). Contributes to transcriptional repression by BCL6 (PubMed : 15454082).
See full target information MTA3
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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