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AB113707

Anti-MTCH2 antibody

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Rabbit Polyclonal MTCH2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MTCH2 conjugated to Keyhole Limpet Haemocyanin.

대체 명칭 보기

MIMP, HSPC032, MTCH2, Mitochondrial carrier homolog 2, Met-induced mitochondrial protein

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MTCH2 antibody (AB113707)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MTCH2 antibody (AB113707)

ab113707, at 5 μg/ml, staining MTCH2 in formalin fixed, paraffin embedded Human small intestine tissue by Immunohistochemistry.

Western blot - Anti-MTCH2 antibody (AB113707)
  • WB

Unknown

Western blot - Anti-MTCH2 antibody (AB113707)

All lanes:

Western blot - Anti-MTCH2 antibody (ab113707) at 1 µg/mL

All lanes:

293 cell lysate

Predicted band size: 33 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human MTCH2 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9Y6C9

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대체품

Primary Antibodies

AB227926

Anti-MTCH2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MTCH2 antibody (AB227926)

  • 0
  • 0

보완 제품

Primary Antibodies

AB57523

Anti-TOMM22/TOM22 antibody [4G4]

Immunocytochemistry/ Immunofluorescence - Anti-TOMM22/TOM22 antibody [4G4] (AB57523)

  • 0
  • 0
Primary Antibodies

AB187027

Anti-RhoA antibody [EPR18134]

20ul selling size|RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-RhoA antibody [EPR18134] (AB187027)

  • 4
  • 1
Primary Antibodies

AB200199

Anti-SRP72 antibody [EPR17143]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-SRP72 antibody [EPR17143] (AB200199)

  • 0
  • 0
Primary Antibodies

AB308510

Anti-CHCHD10 antibody [EPR26966-33]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-CHCHD10 antibody [EPR26966-33] (AB308510)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

MTCH2 also known as Mitochondrial Carrier Homolog 2 serves as a protein involved in mitochondrial function. It has a mass of approximately 33 kDa. This protein sees high levels of expression in adipose tissue liver heart and skeletal muscle indicating its role in energy metabolism and homeostasis. MTCH2 localizes to the outer mitochondrial membrane where it impacts the transfer of metabolic substrates and signals across the mitochondrial barrier.
Biological function summary

MTCH2 plays a significant role in regulating mitochondrial apoptosis and metabolism. It is involved in the control of lipid and glucose metabolism essential for maintaining cellular energy balance. MTCH2 forms part of a larger protein complex associated with the mitochondrial outer membrane and interacts with several key regulators of apoptosis including tBID. Its function is important to maintaining cell survival and regulating programmed cell death in response to metabolic stress.

Pathways

The regulatory role of MTCH2 integrates it into the mitochondrial apoptosis and lipid metabolism pathways. MTCH2 acts synergistically within the apoptosis pathway by influencing the activity of proteins such as Bax. In the lipid metabolism pathway MTCH2 coordinates with proteins like CD36 to regulate fatty acid uptake and oxidation connecting cellular energy demands with supply.

MTCH2 has relevance to metabolic conditions and neurodegenerative diseases. In obesity alterations in MTCH2 function affect energy metabolism and fat accumulation. In Alzheimer's disease MTCH2 interaction with amyloid precursor protein regulates mitochondrial function and could contribute to neuronal death. MTCH2 associating with tBID and Bax further implicates its role in the progression of these conditions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane (PubMed : 36264797). Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins (PubMed : 36264797). Does not mediate insertion of beta-barrel transmembrane proteins (PubMed : 36264797). Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis (By similarity). Regulates the quiescence/cycling of hematopoietic stem cells (HSCs) (By similarity). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs) (By similarity). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology (By similarity).
See full target information MTCH2
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cancer management and research 12:10505-10519 PubMed33122949

2020

Circ_0000260 Regulates the Development and Deterioration of Gastric Adenocarcinoma with Cisplatin Resistance by Upregulating MMP11 via Targeting MiR-129-5p.

Applications

Unspecified application

Species

Unspecified reactive species

Shicheng Liu,Miao Wu,Mengyin Peng
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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