AB220085

Anti-mu Crystallin antibody

(1 리뷰)

(3 제품이 사용된 논문 )

Rabbit Polyclonal mu Crystallin antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CRYM aa 150-250.

대체 명칭 보기

THBP, CRYM, Ketimine reductase mu-crystallin, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase, NADP-regulated thyroid-hormone-binding protein, P2C/Pyr2C reductase

5 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-mu Crystallin antibody (AB220085)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-mu Crystallin antibody (AB220085)

Immunohistochemical analysis of human pancreas tissue labeling mu Crystallin in exocrine glandular cells with ab220085 at a 1/200 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-mu Crystallin antibody (AB220085)

Immunohistochemical analysis of human prostate tissue labeling mu Crystallin in the cytoplasm of glandular cells with ab220085 at a 1/200 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-mu Crystallin antibody (AB220085)

Immunohistochemical analysis of human kidney tissue labeling mu Crystallin in the cytoplasm of cells in tubules with ab220085 at a 1/200 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-mu Crystallin antibody (AB220085)

Immunohistochemical analysis of human cerebral cortex tissue labeling mu Crystallin in the cytoplasm of neurons with ab220085 at a 1/200 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunocytochemistry/ Immunofluorescence - Anti-mu Crystallin antibody (AB220085)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-mu Crystallin antibody (AB220085)

Immunocytochemical analysis of SH-SY5Y (Human neuroblastoma cell line from bone marrow) whole cells labeling mu Crystallin in the cytosol with ab220085 at 2 μg/ml.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human CRYM aa 150-250. The exact immunogen used to generate this antibody is proprietary information.

Q14894

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100</p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Mu Crystallin also known as CRYM is a protein with a molecular weight of approximately 33 kDa. It binds to NADPH functioning as a crystallin-like structure. Mu Crystallin expresses in several tissues with notable presence in the human kidney heart and inner ear. While its original identification was in relation to vertebrate eye lens outside the lens its expression takes on additional roles that align with its involvement in thyroid hormone binding.

Biological function summary

Mu Crystallin plays a part in the regulation of thyroid hormones by acting as a carrier protein for triiodothyronine (T3). It does not belong to any known complex but shows distinction in its binding capabilities. By binding with T3 mu Crystallin modulates the availability of this hormone affecting local cellular environments and hormonal pathways. This interaction influences the normal signaling of thyroid hormones which are essential for maintaining many physiological processes.

Pathways

Mu Crystallin is involved in key processes related to thyroid hormone signaling and metabolic regulation. It fits importantly into the thyroid hormone pathway where it impacts the transportation and eventual metabolism of T3. In relation to this context mu Crystallin interacts with proteins such as thyroid hormone receptors and other binding proteins inherent in the metabolic pathways.

Defects and dysregulation in mu Crystallin function connect to non-syndromic deafness and depressive disorders. Through its role in hormone regulation mu Crystallin's dysfunctions can impact neurotransmitter levels which may contribute to depressive conditions. Furthermore its relationship with other thyroid hormone-related proteins suggests implications in auditory impairments where alterations in hormone availability affect inner ear health.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Catalyzes the NAD(P)H-dependent reduction of imine double bonds of a number of cyclic ketimine substrates, including sulfur-containing cyclic ketimines (PubMed : 21332720, PubMed : 25931162). Under physiological conditions, it efficiently catalyzes delta(1)-piperideine-2-carboxylate (P2C) and delta(1)-pyrroline-2-carboxylate (Pyr2C) reduction, suggesting a central role in lysine and glutamate metabolism (PubMed : 25931162). Additional substrates are delta(2)-thiazoline-2-carboxylate (T2C), 3,4-dehydrothiomorpholine-3-carboxylate (AECK), and (R)-lanthionine ketimine (LK) that is reduced at very low rate compared to other substrates (PubMed : 25931162). Also catalyzes the NAD(P)H-dependent reduction of (S)-cystathionine ketimine (CysK) (By similarity).

See full target information CRYM

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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Acta neuropathologica 147:56 PubMed38478117

2024

Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia.

Applications

Unspecified application

Species

Unspecified reactive species

Christine Marques,Aaron Held,Katherine Dorfman,Joon Sung,Catherine Song,Amey S Kavuturu,Corey Aguilar,Tommaso Russo,Derek H Oakley,Mark W Albers,Bradley T Hyman,Leonard Petrucelli,Clotilde Lagier-Tourenne,Brian J Wainger

Journal of neuroinflammation 20:62 PubMed36890518

2023

Cannabinoids modulate the microbiota-gut-brain axis in HIV/SIV infection by reducing neuroinflammation and dysbiosis while concurrently elevating endocannabinoid and indole-3-propionate levels.

Applications

Unspecified application

Species

Unspecified reactive species

Marina McDew-White,Eunhee Lee,Lakmini S Premadasa,Xavier Alvarez,Chioma M Okeoma,Mahesh Mohan

Cell death & disease 9:854 PubMed30154401

2018

Exosomal miR-21-5p derived from gastric cancer promotes peritoneal metastasis via mesothelial-to-mesenchymal transition.

Applications

Unspecified application

Species

Unspecified reactive species

Qiang Li,Bowen Li,Qing Li,Song Wei,Zhongyuan He,Xiaoxu Huang,Lu Wang,Yiwen Xia,Zhipeng Xu,Zheng Li,Weizhi Wang,Li Yang,Diancai Zhang,Zekuan Xu

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-mu Crystallin antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-mu Crystallin antibody (AB220085)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-mu Crystallin antibody (AB220085)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-mu Crystallin antibody (AB220085)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-mu Crystallin antibody (AB220085)

Immunocytochemistry/ Immunofluorescence - Anti-mu Crystallin antibody (AB220085)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (3)

Product promise