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AB212997

Anti-Myeloid Marker antibody [MYADM/971]

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Mouse Monoclonal Myeloid Marker antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MYADM.

대체 명칭 보기

UNQ553/PRO1110, MYADM, Myeloid-associated differentiation marker, Protein SB135

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myeloid Marker antibody [MYADM/971] (AB212997)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myeloid Marker antibody [MYADM/971] (AB212997)

Formalin-fixed, paraffin-embedded human tonsil tissue stained for Myeloid Marker using ab212997 at 1 μg/ml in immunohistochemical analysis.

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

MYADM/971

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human MYADM.

Q96S97

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보완 제품

Primary Antibodies

AB109110

Anti-EEA1 antibody [EPR4245] - Early Endosome Marker

20ul selling size|RabMAb|Recombinant|KO Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-EEA1 antibody [EPR4245] - Early Endosome Marker (AB109110)

  • 5
  • 4
Primary Antibodies

AB182858

Anti-Bcl-2 antibody [EPR17509]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Bcl-2 antibody [EPR17509] (AB182858)

  • 5
  • 13
Primary Antibodies

AB32503

Anti-Bax antibody [E63]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Bax antibody [E63] (AB32503)

  • 4
  • 12
Primary Antibodies

AB16663

Anti-Cyclin D1 antibody [SP4]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|KO Validated|Lab Essentials

Western blot - Anti-Cyclin D1 antibody [SP4] (AB16663)

  • 4
  • 23
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "<p></p>" }, "Macaque monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A/G
보관 버퍼
pH: 7.2 - 7.4 Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Myeloid markers are important components involved in the identification and characterization of myeloid cells including monocytes macrophages and granulocytes. These markers such as CD14 CD33 and CD68 have a molecular mass that varies depending on the specific marker. Scientists use these markers to study cell lineage and differentiation in hematopoietic cells. They mainly express in bone marrow spleen and peripheral blood where myeloid cells are abundant. Alternate names for myeloid markers include leukocyte antigens which denote their role in leukocyte classification.
Biological function summary

Myeloid markers play significant roles in immune system function and inflammation processes. They help facilitate cell-cell communication and receptor-mediated phagocytosis in immune responses being part of cooperative complexes on cell surfaces. CD14 for instance often associates with TLR4 to mediate responses to bacterial lipopolysaccharides. By aiding the recognition and removal of pathogens myeloid markers support the body's defenses against infections and inflammation.

Pathways

Myeloid markers actively participate in innate immune signaling and inflammation pathways. They are integral to the toll-like receptor (TLR) pathway which helps recognize pathogen-associated patterns. For instance CD14 is involved in the TLR pathway that activates NF-kB and MAP kinase leading to inflammatory cytokine production. Myeloid markers also connect with complement pathways interacting with immune proteins like C3 which further signal cellular immune responses to pathogens.

Altered myeloid marker expression associates with conditions such as leukemia and chronic inflammatory diseases. Acute myeloid leukemia (AML) often involves abnormal expression of myeloid markers like CD33 impacting the differentiation of myeloid-lineage cells. Additionally in chronic inflammatory diseases such as rheumatoid arthritis changes in myeloid marker activity link to dysregulated immune responses. Through these conditions proteins like CD33 become important for diagnostic and therapeutic target considerations.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

See full target information MYADM
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell reports methods 3:100595 PubMed37741277

2023

Dual-modality imaging of immunofluorescence and imaging mass cytometry for whole-slide imaging and accurate segmentation.

Applications

Unspecified application

Species

Unspecified reactive species

Eun Na Kim,Phyllis Zixuan Chen,Dario Bressan,Monika Tripathi,Ahmad Miremadi,Massimiliano di Pietro,Lisa M Coussens,Gregory J Hannon,Rebecca C Fitzgerald,Lizhe Zhuang,Young Hwan Chang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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