AB232897

Anti-Myh14 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal MYH14 antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MYH14 aa 1050 to C-terminus.

대체 명칭 보기

KIAA2034, FP17425, MYH14, Myosin-14, Myosin heavy chain 14, Non-muscle myosin heavy chain IIc, NMHC II-C

5 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myh14 antibody (AB232897)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myh14 antibody (AB232897)

Formalin-fixed, paraffin-embedded human liver cancer tissue stained for Myh14 using ab232897 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myh14 antibody (AB232897)

Formalin-fixed, paraffin-embedded human cerebrum tissue stained for Myh14 using ab232897 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myh14 antibody (AB232897)

Formalin-fixed, paraffin-embedded human liver tissue stained for Myh14 using ab232897 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-Myh14 antibody (AB232897)

All lanes:

Western blot - Anti-Myh14 antibody (ab232897) at 1 µg/mL

All lanes:

Rat brain tissue lysate

Secondary

All lanes:

HRP-Linked Guinea pig anti-Rabbit at 1/2000 dilution

Predicted band size: 228 kDa

false

Supplier Data

Western blot - Anti-Myh14 antibody (AB232897)

All lanes:

Western blot - Anti-Myh14 antibody (ab232897) at 1 µg/mL

All lanes:

Recombinant human Myh14 protein

Secondary

All lanes:

HRP-Linked Guinea pig anti-Rabbit at 1/2000 dilution

Predicted band size: 228 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human MYH14 aa 1050 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q7Z406

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

Purification 관련 사항

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

보관 버퍼

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The protein Myh14 also known as myosin-14 and non-muscle myosin heavy chain IIC is a member of the myosin superfamily of motor proteins. This protein is approximately 227 kDa in mass and plays an important role in cellular motility by facilitating actin-based transport processes. Myh14 is expressed in various tissues including the heart spleen and cerebellum suggesting its involvement in diverse physiological processes.

Biological function summary

Myh14 functions in the cytoskeleton interacting with actin filaments to contribute to processes like cell shape changes and migration. It acts as a part of the non-muscle myosin IIC complex working in tandem with other cytoskeletal elements to provide structural integrity and tension within cells. This activity supports various cellular mechanisms that require precise mechanical movement and stability.

Pathways

Myh14 plays a role in the Rho GTPase signaling pathway and actin cytoskeleton regulation. These pathways are important for cell adhesion and motility influencing how cells interact and communicate in their environments. Myh14's actions are closely related to proteins such as actin and other myosin family members which collectively maintain cytoskeletal dynamics and cellular responses to external signals.

Myh14 has been linked to sensorineural hearing loss and ischemic stroke. Its relationship with disorders involving the auditory system connects it to proteins like Myh9 another myosin family member associated with similar conditions. In cardiovascular pathology alterations in Myh14 expression may affect cellular responses during tissue damage such as those observed in stroke linking it to physiological processes and potential therapeutic targets.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.

See full target information MYH14

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of personalized medicine 14: PubMed38673008

2024

Alteration of the Expression and Functional Activities of Myosin II Isoforms in Enlarged Hyperplastic Prostates.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao Wang,Weixiang He,Hui Chen,Rui Yang,Hongmei Su,Michael E DiSanto,Xinhua Zhang

Aging 13:23739-23756 PubMed34689137

2021

Loganin substantially ameliorates molecular deficits, pathologies and cognitive impairment in a mouse model of Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Lulin Nie,Kaiwu He,Fengzhu Xie,Shifeng Xiao,Shupeng Li,Jia Xu,Kaiqin Zhang,Chen Yang,Li Zhou,Jianjun Liu,Liangyu Zou,Xifei Yang

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Myh14 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myh14 antibody (AB232897)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myh14 antibody (AB232897)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myh14 antibody (AB232897)

Western blot - Anti-Myh14 antibody (AB232897)

Western blot - Anti-Myh14 antibody (AB232897)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (2)

Product promise