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AB122620

Anti-MYO16 antibody

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Rabbit Polyclonal MYO16 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MYO16 aa 800-950.

대체 명칭 보기

KIAA0865, MYO16B, NYAP3, MYO16, Unconventional myosin-XVI, Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3, Unconventional myosin-16

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYO16 antibody (AB122620)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYO16 antibody (AB122620)

Immunohistochemical analysis of paraffin-embedded Human testis tissue labeling MYO16 with ab122620 used at dilution : 1/200 - 1/500.

Moderate cytoplasmic positivity in cells in seminiferous ducts.

The section was incubated with ab122620 for 30 mins at room temperature.

The immunostaining was performed with an automated IHC staining platform using a labeled polymer as secondary reagent incubated for 30 minutes at room temperature.

Counterstained with Hematoxylin.

Heat mediated antigen retrieval was performed with Sodium-Citrate buffer (pH 6.0, Epitope Retrieval Solution1) for 10 mins.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MYO16 aa 800-950. The exact immunogen used to generate this antibody is proprietary information.

Q9Y6X6

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보완 제품

Primary Antibodies

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL1 Receptor I/IL-1R-1 antibody [EPR20150-241] - BSA and Azide free (Detector) (AB244859)

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Primary Antibodies

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Primary Antibodies

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Primary Antibodies

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha smooth muscle Actin antibody [EPR5368] (AB124964)

  • 5
  • 19
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
보관 정보
Avoid freeze / thaw cycle|Store undiluted
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

MYO16 also known as Myosin XVI is a member of the myosin superfamily of actin-based motor proteins. It weighs approximately 200 kDa. This protein exhibits ATPase activity and plays a role in intracellular transport and cell motility. MYO16 expresses predominantly in the brain but can also be found in other tissues. This expression pattern suggests it has significant functions in neural cells.
Biological function summary

Myosin XVI functions extend to maintaining cellular architecture and facilitating signal transduction processes. MYO16 might interact with various cytoskeletal components contributing to structural dynamics within cells. MYO16 may co-localize with specific proteins to form complexes influencing its functional role in neuronal pathways and affecting cellular responses.

Pathways

MYO16 integrates into signaling networks involving actin dynamics and cellular motility. It holds a potential role in pathways such as the Wnt signaling pathway and may interact with proteins like beta-catenin which are essential in cellular growth and differentiation. The interaction with cellular components highlights its involvement in modulating neuronal circuitry and connectivity.

MYO16 links with neurological conditions such as schizophrenia and autism spectrum disorders. Researchers continue to explore how MYO16 influences these diseases potentially through its interaction with proteins like DISC1 (Disrupted in Schizophrenia 1). Understanding MYO16's role in these disorders could provide potential insights into their underlying mechanisms.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity).
See full target information MYO16
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Oncogene 44:3255-3271 PubMed40640336

2025

Human RNase H2 upregulation counteracts oncogene- and chemotherapy-induced replication stress.

Applications

Unspecified application

Species

Unspecified reactive species

Rosanna J Wilkins,Abirami Kannan,Siobhan A Plass,Claire Wilson,Richard D W Kelly,Claire H M Tang,Panagiotis Kotsantis,Martin A M Reijns,Aditi Kanhere,Eva Petermann
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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