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AB233263

Anti-MYOM2 antibody

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Rabbit Polyclonal MYOM2 antibody. Suitable for WB, IHC-P and reacts with Pig, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MYOM2 aa 1100-1450.

대체 명칭 보기

Myomesin-2, 165 kDa connectin-associated protein, 165 kDa titin-associated protein, M-protein, Myomesin family member 2, MYOM2

4 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYOM2 antibody (AB233263)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYOM2 antibody (AB233263)

Formalin-fixed, paraffin-embedded human brain tissue stained for MYOM2 using ab233263 at 20 μg/mL in immunohistochemical analysis. DAB staining.

Western blot - Anti-MYOM2 antibody (AB233263)
  • WB

Supplier Data

Western blot - Anti-MYOM2 antibody (AB233263)

All lanes:

Western blot - Anti-MYOM2 antibody (ab233263) at 2 µg/mL

All lanes:

Recombinant human MYOM2 protein

Predicted band size: 165 kDa

false

Western blot - Anti-MYOM2 antibody (AB233263)
  • WB

Supplier Data

Western blot - Anti-MYOM2 antibody (AB233263)

All lanes:

Western blot - Anti-MYOM2 antibody (ab233263) at 2 µg/mL

All lanes:

Pig skeletal muscle lysate

Predicted band size: 165 kDa

false

Western blot - Anti-MYOM2 antibody (AB233263)
  • WB

Supplier Data

Western blot - Anti-MYOM2 antibody (AB233263)

All lanes:

Western blot - Anti-MYOM2 antibody (ab233263) at 2 µg/mL

All lanes:

Pig heart lysate

Predicted band size: 165 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Pig

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MYOM2 aa 1100-1450. The exact immunogen used to generate this antibody is proprietary information.

P54296

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보완 제품

Primary Antibodies

AB121973

Anti-MYOM3 antibody

Immunocytochemistry/ Immunofluorescence - Anti-MYOM3 antibody (AB121973)

  • 0
  • 0
Primary Antibodies

AB79935

Anti-Myosin Light Chain 2 antibody

BOND RX™ Validated

Western blot - Anti-Myosin Light Chain 2 antibody (AB79935)

  • 5
  • 2
Primary Antibodies

AB233513

Anti-CD42d/GP5 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD42d/GP5 antibody (AB233513)

  • 0
  • 0
Primary Antibodies

AB211777

Anti-NR2F2 antibody [EPR18443]

RabMAb|Recombinant|Advanced Validation|20ul selling size|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NR2F2 antibody [EPR18443] (AB211777)

  • 5
  • 2
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
보관 버퍼
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

MYOM2 also known as myomesin-2 is a protein involved in muscle structure and function. It has a molecular mass of roughly 166 kDa. This protein is predominantly expressed in cardiac and skeletal muscle tissues. MYOM2 plays an important mechanical role by contributing to the M-line of the sarcomere which is essential for muscle elasticity and contractility acting as a link between myosin thick filaments and other structural proteins within the muscle cell.
Biological function summary

MYOM2 integrates into the sarcomeric M-band complex. This complex is important for maintaining the structural integrity of myofibrils. MYOM2 stabilizes interactions between the thick filament protein myosin and other M-band proteins such as myomesin-1 and myomesin-3. This stabilization supports muscle contraction processes and overall muscle fiber architecture adapting muscle cells to mechanical stress.

Pathways

MYOM2 is involved in muscle contraction and structural organization pathways. Specifically it plays a part in the myofibril assembly pathway where it collaborates with other proteins like titin and myosin binding protein C to ensure proper sarcomere assembly. These interactions help maintain the functional properties of muscle tissues contributing to force generation and transmission across muscle cells.

MYOM2 has associations with muscle-related diseases particularly hypertrophic cardiomyopathy (HCM). This disease impacts cardiac muscle and is linked with mutations or variations in MYOM2 and related proteins such as myomesin-1 and titin. Additionally MYOM2 may contribute to myofibrillar myopathy a disorder characterized by disorganization of myofibrils within muscle cells where changes in its structure can disrupt muscle function.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
See full target information MYOM2
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of controlled release : official journal of the Controlled Release Society 355:579-592 PubMed36746337

2023

TOP-EVs: Technology of Protein delivery through Extracellular Vesicles is a versatile platform for intracellular protein delivery.

Applications

Unspecified application

Species

Unspecified reactive species

Nazma F Ilahibaks,Arif I Ardisasmita,Songpu Xie,Anders Gunnarsson,Joseph Brealey,Pieter Vader,Olivier G de Jong,Saskia de Jager,Niek Dekker,Ben Peacock,Raymond M Schiffelers,Joost P G Sluijter,Zhiyong Lei
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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