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AB241982

Anti-Myotrophin antibody

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Rabbit Polyclonal Myotrophin antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MTPN aa 50 to C-terminus.

대체 명칭 보기

Myotrophin, Protein V-1, MTPN

1 이미지
Western blot - Anti-Myotrophin antibody (AB241982)
  • WB

Supplier Data

Western blot - Anti-Myotrophin antibody (AB241982)

Lysates prepared using NETN lysis buffer.

Lane 1:

Western blot - Anti-Myotrophin antibody (ab241982) at 0.1 µg/mL

Lanes 2 - 5:

Western blot - Anti-Myotrophin antibody (ab241982) at 0.1 µg

Lane 1:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 15 µg

Lane 2:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 15 µg

Lane 3:

Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate at 15 µg

Lane 4:

TCMK-1 (mouse kidney epithelial cell line) whole cell lysate at 15 µg

Lane 5:

NIH/3T3 (mouse embryo fibroblast cell line) whole cell lysate at 15 µg

Predicted band size: 13 kDa

true

Exposure time: 3min

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human MTPN aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P58546

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보완 제품

Primary Antibodies

AB311847

Anti-Indoleamine 2, 3-dioxygenase antibody [EPR28349-89]

BOND RX™ Validated|20ul selling size|KO Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Indoleamine 2, 3-dioxygenase antibody [EPR28349-89] (AB311847)

  • 0
  • 0
Primary Antibodies

AB234663

Anti-MTX1/MTX antibody

  • 0
  • 0
Primary Antibodies

AB201316

Anti-MYH8 antibody

Western blot - Anti-MYH8 antibody (AB201316)

  • 0
  • 0
Primary Antibodies

AB102575

Anti-MTMR14 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MTMR14 antibody (AB102575)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
Antibody was affinity purified using an epitope specific to Myotrophin immobilized on solid support.
보관 버퍼
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Myotrophin also known as V-1 is a protein that facilitates numerous cellular activities. This protein has a molecular weight of approximately 12 kDa and is expressed in several tissues including cardiac and skeletal muscles. It shows high presence in the brain and heart suggesting significant roles in these organs. Myotrophin's ability to modulate multiple cellular functions makes it a target of interest in scientific research focused on cardiac function and neurobiology.
Biological function summary

This protein plays a role in modulating cardiac muscle cell hypertrophy directly affecting heart muscle growth. Myotrophin participates in forming a complex with other proteins such as calpactin which influences actin filament dynamics. This interaction is essential for cellular structural maintenance and function. Additionally myotrophin acts as a transcription factor modulator impacting the expression of genes associated with cellular growth and differentiation.

Pathways

Myotrophin integrates into signaling networks like the NF-kB and MAPK pathways. These pathways are critical for cellular responses to stress and inflammation. Myotrophin interacts with proteins such as p65 (a subunit of NF-kB) to modulate transcriptional activities that regulate these pathways. By influencing these pathways myotrophin plays a substantial role in cellular adaptation and stress response mechanisms.

Myotrophin associates with cardiovascular diseases like hypertrophic cardiomyopathy and heart failure. It contributes to the pathological remodeling of heart tissue through its impact on hypertrophy. Additionally it shows implications in neurodegenerative diseases linked through the protein α-synuclein. Alterations in myotrophin levels and function can disrupt normal cellular processes leading to the progression of these critical diseases.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy.
See full target information MTPN
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in cell and developmental biology 7:351 PubMed31921861

2019

Role of TGF-β/Smad Pathway in the Transcription of Pancreas-Specific Genes During Beta Cell Differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Yuhua Gao,Ranxi Zhang,Shanshan Dai,Xue Zhang,Xiangchen Li,Chunyu Bai
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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