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AB237053

Anti-Myozenin 2 antibody

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Rabbit Polyclonal Myozenin 2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MYOZ2 aa 50-200.

대체 명칭 보기

C4orf5, MYOZ2, Myozenin-2, Calsarcin-1, FATZ-related protein 2

2 이미지
Immunocytochemistry/ Immunofluorescence - Anti-Myozenin 2 antibody (AB237053)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Myozenin 2 antibody (AB237053)

HeLa (Human epithelial cell line from cervix adenocarcinoma) cells labeling Myozenin 2 (green) using ab237053 at 1/100 dilution in ICC/IF, followed by an Alexa-Fluor®488-conjugated goat anti-rabbit IgG (H+L). Countersatined with DAPI (blue).

The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal goat serum. The cells were then incubated with the antibody overnight at 4°C.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myozenin 2 antibody (AB237053)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myozenin 2 antibody (AB237053)

Paraffin-embedded human heart tissue stained for Myozenin 2 using ab237053 at 1/300 dilution in immunohistochemical analysis.

After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum for 30 minutes at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human MYOZ2 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.

Q9NPC6

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보완 제품

Primary Antibodies

AB272607

Anti-MTX2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MTX2 antibody (AB272607)

  • 0
  • 0
Primary Antibodies

AB230232

Anti-MTERFD1/MTERF3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MTERFD1/MTERF3 antibody (AB230232)

  • 0
  • 0
Primary Antibodies

AB121243

Anti-MTIF2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MTIF2 antibody (AB121243)

  • 3
  • 1
Primary Antibodies

AB230321

Anti-MTIF3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MTIF3 antibody (AB230321)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Myozenin 2 also known as calsarcin-1 mechanically functions as a scaffold protein that anchors filamentous actin to the sarcomeric Z-disc in striated muscles. It weighs approximately 32 kDa. Myozenin 2 is primarily expressed in cardiac and skeletal muscle tissues where it plays an important role in maintaining the structural integrity of muscle fibers. Its interaction with other proteins at the Z-disc is important for muscle function.
Biological function summary

Myozenin 2 contributes to the regulation of muscle contraction and signal transduction within muscle cells. It forms part of a multiprotein complex at the Z-disc where it interfaces with proteins such as telethonin and myotilin. This positioning aids in the transmission of mechanical and signaling information necessary for muscle adaptation and maintenance.

Pathways

Myozenin 2 has roles in the regulation of muscle hypertrophy and myopathy pathways. This protein interacts closely with calcineurin a phosphatase involved in calcium-dependent signaling pathways that regulate muscle growth and differentiation. Additionally Myozenin 2 can affect protein kinase C pathways which are essential for modulating the cellular responses to mechanical stress in muscle tissues.

Myozenin 2 is linked to conditions such as familial hypertrophic cardiomyopathy and muscular dystrophy. Changes in the expression or function of Myozenin 2 can lead to disrupted Z-disc integrity and impaired muscle function. In cardiomyopathy Myozenin 2's interaction with calcineurin becomes relevant as alterations in this interaction may contribute to the pathogenesis. In muscular dystrophy its relationship with telethonin becomes significant influencing the structural stability of muscle cells.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
See full target information MYOZ2
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Immunology 172:588-599 PubMed38634546

2024

Oligodeoxynucleotides containing CpG motifs (CpG-ODN) restores immune regulatory functions of airway macrophages of patients with asthma.

Applications

Unspecified application

Species

Unspecified reactive species

Huanping Zhang,Lihuan Wang,Aizhi Zhang,Xiangyu Wang,Yun Liao,Xiaoxue Chen,Xuejie Xu,Litao Yang,Yu Liu,Aifa Tang,Pingchang Yang
제품이 사용된 논문 모두 보기
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Product promise

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