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AB122177

Anti-Nance-Horan Syndrome Protein antibody

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Rabbit Polyclonal Nance-Horan Syndrome Protein antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human NHS aa 1100 to C-terminus.

대체 명칭 보기

Actin remodeling regulator NHS, Congenital cataracts and dental anomalies protein, Nance-Horan syndrome protein, NHS

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nance-Horan Syndrome Protein antibody (AB122177)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nance-Horan Syndrome Protein antibody (AB122177)

ab122177 at 1/35 dilution staining Nance-Horan Syndrome Protein in Paraffin-embedded Human Liver tissue by Immunohistochemistry.

Immunocytochemistry/ Immunofluorescence - Anti-Nance-Horan Syndrome Protein antibody (AB122177)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Nance-Horan Syndrome Protein antibody (AB122177)

Immunofluorescent staining of Human cell line U-2 OS shows positivity in nucleus but not nucleoli. Recommended concentration of ab122177 1-4 µg/ml. Cells treated with PFA/Triton X-100.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human NHS aa 1100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q6T4R5

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보완 제품

Primary Antibodies

AB201022

Anti-ATM antibody [EPR20100] - ChIP Grade

RabMAb|Recombinant|KO Validated|20ul selling size

Flow Cytometry (Intracellular) - Anti-ATM antibody [EPR20100] - ChIP Grade (AB201022)

  • 0
  • 0
Primary Antibodies

AB81292

Anti-ATM (phospho S1981) antibody [EP1890Y]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATM (phospho S1981) antibody [EP1890Y] (AB81292)

  • 5
  • 18
Primary Antibodies

AB109413

Anti-Chk2 antibody [EPR4325]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Chk2 antibody [EPR4325] (AB109413)

  • 5
  • 9
Primary Antibodies

AB40866

Anti-Chk1 antibody [EP691Y]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Chk1 antibody [EP691Y] (AB40866)

  • 5
  • 6
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-4 µg/mL", "ICCIF-species-notes": "<p>Recommend PFA Fixation and Triton X-100 treatment</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Nance-Horan Syndrome Protein also known as NHS plays an important role within the cell. Mechanically NHS is involved in cytoskeleton organization and cell morphogenesis. The protein has a mass of approximately 163 kDa. It is expressed in a range of tissues with notable expression in the eye and craniofacial regions. The NHS protein is important for proper cellular structure and organization of the actin cytoskeleton.
Biological function summary

The Nance-Horan Syndrome Protein is involved in cell differentiation and development. It acts as part of a larger protein complex that regulates cellular stability and morphology. This involvement is essential in maintaining the integrity of tissues particularly in areas like the eye lens and dental structures where precise cell architecture is significant for function. The protein's specific interactions in these biological processes highlight its importance within dynamic cellular environments.

Pathways

The Nance-Horan Syndrome Protein intersects with developmental signaling pathways. It particularly associates with the Wnt signaling pathway which is critical for tissue morphogenesis and cell fate determination. In this pathway NHS interacts with proteins such as β-catenin helping regulate gene expression and maintaining tissue-specific functions. The NHS protein's activity within this pathway supports the development of anatomical structures necessitating precise cellular communication.

The Nance-Horan Syndrome Protein is closely linked to Nance-Horan Syndrome an X-linked developmental disorder. This syndrome primarily affects the eyes teeth and face demonstrating how disruptions in NHS function can lead to pronounced phenotype alterations. Additionally mutations or malfunctions in NHS can relate to congenital cataracts further emphasizing its role in ocular development. Proteins like FOXC1 have connections with NHS-related pathways illustrating its broader implications in embryonic development and disease manifestation.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development.
See full target information NHS
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

International journal of oncology 64: PubMed38426627

2024

Characterization of KIF20B as a novel prognostic biomarker and therapeutic target for breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Regina Wachuka Mbugua,Atsushi Takano,Bayarbat Tsevegjav,Tomoyuki Yokose,Toshinari Yamashita,Yohei Miyagi,Yataro Daigo
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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