AB36392

Anti-Natural Killer Cell Activation Structures antibody [ANK61]

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(12 제품이 사용된 논문 )

Mouse Monoclonal Natural Killer Cell Activation Structures antibody. Suitable for IP, Flow Cyt, IHC-P, IHC-Fr and reacts with Rat samples. Cited in 12 publications. Immunogen corresponding to Cell preparation containing Natural Killer Cell Activation Structures protein.

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

ANK61

Isotype

IgG1

Carrier free

Reacts with

Rat

Applications

IHC-P, IHC-Fr, Flow Cyt, IP

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

The antigen recognized by ab36392 is highly expressed on freshly isolated and cultured NK cells. The antibody also binds to rat alpha beta TCR T cells and at a low level to B cells.

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<a href='/ko/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }

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제품 세부 정보

Triggering of the antigen by ab36392 antibody activates the lytic machinery of rat NK cells, but not of T cells.

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특성 및 보관 정보

제형

Liquid

Purity

Tissue culture supernatant

보관 버퍼

pH: 7.3 Preservative: 0.05% Sodium azide Constituents: Tissue culture supernatant

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Natural Killer (NK) Cell Activation Structures are essential components responsible for triggering the killing activity of NK cells. These structures are primarily located on the surface of NK cells where they interact with ligands on target cells. The mass of these activation structures can vary as they often comprise clusters of proteins such as CD16 also known as Fc receptor IIIA and their associated molecules. CD16 has an estimated molecular weight of around 50 kDa. NK cell activation structures are expressed across various tissues where immune surveillance is necessary.

Biological function summary

These structures serve to initiate the cytotoxic response of NK cells by recognizing stressed cells and those lacking "self" markers. When NK cell activation structures engage target cells they form part of a complex that includes proteins such as NKG2D and NKp46. These complexes recognize specific ligands on potential target cells facilitating the release of cytotoxic granules and cytokines. This biological function ensures that NK cells can target and eliminate infected or cancerous cells while sparing normal cells.

Pathways

NK cell activation structures play an important role in the immune response pathways specifically the natural cytotoxicity pathway. They interact with signaling molecules like DAP10 and DAP12 which transmit activation signals to the interior of the NK cells. This signal transduction enhances the ability of NK cells to respond to infections and cancerous changes. Another pathway is the Fc receptor pathway in which CD16 is associated with the activation of NK cells through antibody-dependent cellular cytotoxicity (ADCC).

Activating structures of NK cells have connections to conditions such as cancer and autoimmune diseases. In cancer defective NK cell activation can lead to insufficient immune surveillance allowing tumor cells to proliferate. Malfunctions in these structures potentially linked with proteins like MHC class I chain-related proteins can also result in an autoimmune response where NK cells mistakenly target healthy tissue. Understanding and targeting these structures might lead to improved therapeutic strategies for modulating immune responses in these diseases.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

See full target information Natural Killer Cell Activation Structures

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제품이 사용된 논문 (12)

Recent publications for all applications. Explore the 전체 목록 and refine your search

American journal of reproductive immunology (New York, N.Y. : 1989) 92:e13895 PubMed39001587

2024

IL-33 Signaling Inhibition Leads to a Preeclampsia-Like Phenotype in Pregnant Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Xi Wang,Corbin A Shields,Deanna Thompson,Jie McKay,Rachel Wilson,Marcus K Robbins,Hannah Glenn,Molly Fontenot,Jan M Williams,Denise C Cornelius

American journal of physiology. Heart and circulatory physiology 326:H1006-H1016 PubMed38363211

2024

IL-33 supplementation improves uterine artery resistance and maternal hypertension in response to placental ischemia.

Applications

Unspecified application

Species

Unspecified reactive species

Xi Wang,Corbin Shields,Geilda Tardo,Greg Peacock,Emily Hester,Marissa Anderson,Jan M Williams,Denise C Cornelius

International journal of molecular sciences 25: PubMed38255935

2024

Inhibition of Caspase 1 Reduces Blood Pressure, Cytotoxic NK Cells, and Inflammatory T-Helper 17 Cells in Placental Ischemic Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Corbin A Shields,Geilda A Tardo,Xi Wang,Gregory Peacock,Marcus Robbins,Hannah Glenn,Rachel Wilson,Jan M Williams,Denise C Cornelius

American journal of physiology. Regulatory, integrative and comparative physiology 324:R556-R567 PubMed36847598

2023

NLRP3 inhibition improves maternal hypertension, inflammation, and vascular dysfunction in response to placental ischemia.

Applications

Unspecified application

Species

Unspecified reactive species

Xi Wang,Olivia K Travis,Corbin A Shields,G Ann Tardo,Chelsea Giachelli,Christopher W Nutter,Hannah L Glenn,Olive G Cooper,Tatiana Davis,Rashauna Thomas,Jan M Williams,Denise C Cornelius

American journal of physiology. Regulatory, integr : PubMed33533305

2021

Progesterone induced blocking factor improves blood pressure, inflammation and pup weight in response to reduced uterine perfusion pressure (RUPP).

Applications

Unspecified application

Species

Unspecified reactive species

Jesse N Cottrell,Alexis Witcher,Kyleigh M Comley,Mark W Cunningham,Tarek Ibrahim,Denise C Cornelius,Babbette D LaMarca,Lorena M Amaral

American journal of reproductive immunology (New York, N.Y. : 1989) 85:e13386 PubMed33315281

2020

Adoptive transfer of placental ischemia-stimulated natural killer cells causes a preeclampsia-like phenotype in pregnant rats.

Applications

Unspecified application

Species

Unspecified reactive species

Olivia K Travis,Cedar Baik,Geilda A Tardo,Lorena Amaral,Carmilya Jackson,Mallory Greer,Chelsea Giachelli,Tarek Ibrahim,Owen T Herrock,Jan M Williams,Denise C Cornelius

American journal of physiology. Regulatory, integr 318:R1036-R1046 PubMed32320265

2020

Interleukin-17 signaling mediates cytolytic natural killer cell activation in response to placental ischemia.

Applications

Unspecified application

Species

Unspecified reactive species

Olivia K Travis,Dakota White,Cedar Baik,Chelsea Giachelli,Willie Thompson,Cassandra Stubbs,Mallory Greer,James P Lemon,Jan Michael Williams,Denise C Cornelius

Physiological reports 7:e14038 PubMed30963715

2019

Chronic infusion of interleukin-17 promotes hypertension, activation of cytolytic natural killer cells, and vascular dysfunction in pregnant rats.

Applications

Unspecified application

Species

Unspecified reactive species

Olivia K Travis,Dakota White,W Austin Pierce,Ying Ge,Cassandra Y Stubbs,Frank T Spradley,Jan M Williams,Denise C Cornelius

American journal of physiology. Regulatory, integrative and comparative physiology 316:R165-R171 PubMed30624978

2019

Interleukin-4 supplementation improves the pathophysiology of hypertension in response to placental ischemia in RUPP rats.

Applications

Unspecified application

Species

Unspecified reactive species

Jesse N Cottrell,Lorena M Amaral,Ashlyn Harmon,Denise C Cornelius,Mark W Cunningham,Venkata Ramana Vaka,Tarek Ibrahim,Florian Herse,Gerd Wallukat,Ralf Dechend,Babbette LaMarca

American journal of physiology. Regulatory, integr 315:R336-R343 PubMed29718698

2018

Placental ischemia-stimulated T-helper 17 cells induce preeclampsia-associated cytolytic natural killer cells during pregnancy.

Applications

Unspecified application

Species

Unspecified reactive species

Corbin A Shields,Maggie McCalmon,Tarek Ibrahim,Dakota L White,Jan M Williams,Babbette LaMarca,Denise C Cornelius

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Natural Killer Cell Activation Structures antibody [ANK61]

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

보완 제품

Primary Antibodies

Assay Kits

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purity

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (12)

Product promise