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AB233808

Anti-NCR1/NKp46 antibody [2B11E12]

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Mouse Monoclonal NCR1 antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NCR1.

대체 명칭 보기

CD335, LY94, NCR1, Natural cytotoxicity triggering receptor 1, Lymphocyte antigen 94 homolog, NK cell-activating receptor, Natural killer cell p46-related protein, NK-p46, NKp46, hNKp46

3 이미지
Flow Cytometry - Anti-NCR1/NKp46 antibody [2B11E12] (AB233808)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-NCR1/NKp46 antibody [2B11E12] (AB233808)

Flow cytometric analysis of HL-60 (human promyelocytic leukemia cell line) cells labeling NCR1 using ab233808 at 1/200 dilution (green) compared with a negative control (red).

Western blot - Anti-NCR1/NKp46 antibody [2B11E12] (AB233808)
  • WB

Supplier Data

Western blot - Anti-NCR1/NKp46 antibody [2B11E12] (AB233808)

Expected MW is 52.8 kDa.

All lanes:

Western blot - Anti-NCR1/NKp46 antibody [2B11E12] (ab233808) at 1/500 dilution

All lanes:

Recombinant human NCR1 protein

Predicted band size: 34 kDa

false

Western blot - Anti-NCR1/NKp46 antibody [2B11E12] (AB233808)
  • WB

Supplier Data

Western blot - Anti-NCR1/NKp46 antibody [2B11E12] (AB233808)

All lanes:

Western blot - Anti-NCR1/NKp46 antibody [2B11E12] (ab233808) at 1/500 dilution

Lane 1:

HEK-293 (human epithelial cell line from embryonic kidney) cell lysate

Lane 2:

NCR1 (aa 22-258)-hIgGFc transfected HEK-293 cell lysate.

Predicted band size: 34 kDa

false

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

2B11E12

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

Flow Cyt, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human NCR1.

O76036

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대체품

Primary Antibodies

AB14823

Anti-NCR1/NKp46 antibody [n1D9]

Flow Cytometry - Anti-NCR1/NKp46 antibody [n1D9] (AB14823)

  • 0
  • 0
Primary Antibodies

AB199128

Anti-NCR1/NKp46 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NCR1/NKp46 antibody (AB199128)

  • 0
  • 0
Primary Antibodies

AB214468

Anti-NCR1/NKp46 antibody

Western blot - Anti-NCR1/NKp46 antibody (AB214468)

  • 4
  • 4
Primary Antibodies

AB89877

Anti-NCR1/NKp46 antibody [MM0491-8F24]

  • 5
  • 4

보완 제품

Assay Kits

AB282310

Human NCR1/NKp46 ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human NCR1/NKp46 ELISA Kit (AB282310)

  • 0
  • 0
Primary Antibodies

AB16669

Anti-CD3 epsilon antibody [SP7]

BOND RX™ Validated|RabMAb|Advanced Validation|Recombinant|Lab Essentials|20ul selling size

Multiplex immunohistochemistry - Anti-CD3 epsilon antibody [SP7] (AB16669)

  • 4
  • 80
Primary Antibodies

AB201811

Anti-PD1 antibody [NAT105] - BSA and Azide free

BOND RX™ Validated|Recombinant

Immunohistochemistry (Frozen sections) - Anti-PD1 antibody [NAT105] - BSA and Azide free (AB201811)

  • 0
  • 0
Primary Antibodies

AB75813

Anti-NCAM1 antibody [EP2567Y]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NCAM1 antibody [EP2567Y] (AB75813)

  • 4
  • 7
Primary Antibodies

AB260035

Anti-NKG2A antibody [EPR23737-127]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Multiplex immunohistochemistry - Anti-NKG2A antibody [EPR23737-127] (AB260035)

  • 5
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/200 - 1/400", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purified from tissue culture supernatant.
보관 버퍼
Preservative: 0.05% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

NCR1 also known as NKp46 is a receptor mainly expressed on the surface of natural killer (NK) cells. Its primary role involves recognizing and binding to ligands present on target cells including tumor cells and virus-infected cells. NCR1 initiates the activation of NK cells leading to the destruction of these abnormal cells. The NCR1 protein has a molecular weight of approximately 46 kDa and is a part of the immunoglobulin superfamily. NCR1 is mainly expressed in the immune system specifically on NK cells which are an important component of the innate immune response.
Biological function summary

The function of NCR1 involves the recognition of stressed transformed or infected cells marking them for elimination by NK cells. It does not typically function as a part of a complex; rather it serves a somewhat autonomous role in cell signaling. However its interaction with other receptors on NK cells including DAP12 enhances its signaling capabilities. Through the activation of cascades NCR1 promotes the release of cytotoxic granules and the production of cytokines therefore mediating the immune response.

Pathways

NCR1 plays a significant role in the regulation of immune surveillance pathways. It is involved in the recognition and elimination pathways that modulate the immune response against infected or cancerous cells. NK cells with NCR1's involvement interact with receptors like NKG2D adjusting the NK cell's cytotoxic activity. These interactions coordinate the broader immune response important for innate immunity effectively bridging innate and adaptive immunity by influencing other immune cells.

NCR1 has been implicated in cancer and infectious diseases. In cancer altered expression or dysfunction of NCR1 may contribute to the evasion of immune surveillance by tumor cells potentially leading to tumor progression. Studies have shown reduced NKp46 expression in some cancerous states linking it to poor prognosis. In infectious diseases NCR1 plays a role in targeting virus-infected cells and its dysfunction can result in reduced effectiveness in clearing viral infections. Interactions with viral envelope proteins can interfere with NCR1 activity exemplifying its importance in antiviral defense mechanisms.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
See full target information NCR1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular cell 82:2779-2796.e10 PubMed35675814

2022

AKT constitutes a signal-promoted alternative exon-junction complex that regulates nonsense-mediated mRNA decay.

Applications

Unspecified application

Species

Unspecified reactive species

Hana Cho,Elizabeth T Abshire,Maximilian W Popp,Christoph Pröschel,Joshua L Schwartz,Gene W Yeo,Lynne E Maquat
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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