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AB237052

Anti-NDRG4 antibody

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Rabbit Polyclonal NDRG4 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human NDRG4 aa 200-350.

대체 명칭 보기

BDM1, KIAA1180, NDRG4, Protein NDRG4, Brain development-related molecule 1, N-myc downstream-regulated gene 4 protein, Vascular smooth muscle cell-associated protein 8, SMAP-8

4 이미지
Immunocytochemistry/ Immunofluorescence - Anti-NDRG4 antibody (AB237052)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-NDRG4 antibody (AB237052)

HepG2 (Human liver hepatocellular carcinoma cell line) cells labeling NDRG4 using ab237052 at 1/100 dilution in ICC/IF, followed by an Alexa-Fluor®488-conjugated goat anti-rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NDRG4 antibody (AB237052)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NDRG4 antibody (AB237052)

Paraffin-embedded human heart tissue stained for NDRG4 using ab237052 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NDRG4 antibody (AB237052)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NDRG4 antibody (AB237052)

Paraffin-embedded human brain tissue stained for NDRG4 using ab237052 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-NDRG4 antibody (AB237052)
  • WB

Supplier Data

Western blot - Anti-NDRG4 antibody (AB237052)

All lanes:

Western blot - Anti-NDRG4 antibody (ab237052) at 1/500 dilution

All lanes:

A549 (Human lung carcinoma cell line) cell lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/50000 dilution

Predicted band size: 38 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human NDRG4 aa 200-350. The exact immunogen used to generate this antibody is proprietary information.

Q9ULP0

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보완 제품

Primary Antibodies

AB86078

Anti-MYCBP2 antibody

Western blot - Anti-MYCBP2 antibody (AB86078)

  • 4
  • 1
Primary Antibodies

AB122273

Anti-METTL8 antibody

Immunocytochemistry/ Immunofluorescence - Anti-METTL8 antibody (AB122273)

  • 0
  • 0
Primary Antibodies

AB250359

Anti-MMP23 antibody [EPR7769] - BSA and Azide free

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-MMP23 antibody [EPR7769] - BSA and Azide free (AB250359)

  • 0
  • 0
Primary Antibodies

AB121146

Anti-TAGLN2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TAGLN2 antibody (AB121146)

  • 5
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

NDRG4 also known as N-Myc downstream-regulated gene 4 is a protein that functions mechanically in cellular processes such as growth and differentiation. Its molecular mass is approximately 43 kDa. This protein is widely expressed in various tissues with notable expression in the heart brain and skeletal muscle. NDRG4 plays a role in cellular stress response and signal transduction by undergoing phosphorylation which aids in the modulation of its activity.
Biological function summary

NDRG4 participates in nervous system development and proper functioning. It is involved in axon growth and guidance important for neuron connectivity. While NDRG4 does not often form part of large protein complexes it interacts with other proteins to facilitate these processes. For instance it coordinates with signaling molecules to affect cytoskeletal dynamics and myelination contributing to neural maintenance.

Pathways

Scientists recognize NDRG4's involvement in signaling pathways like the MAPK pathway pivotal in transmitting extracellular signals to the nucleus to promote cell survival and differentiation. In this pathway NDRG4 interacts with proteins such as ERK1/2 highlighting its role in signal transduction. Another relevant pathway is the PI3K/Akt pathway where NDRG4 influences cell growth and metabolism through interactions with proteins like PI3K further emphasizing its significance in cellular health and function.

Prominently studied ones connected to NDRG4 include cancer and neurological disorders. In cancer alterations in NDRG4 expression can correlate with tumor growth potentially through its interaction with metastasis-related proteins such as NDRG1. Regarding neurological disorders alterations in NDRG4 expression or function have been linked to Alzheimer's disease connecting it with amyloid-beta peptide accumulation and tau protein pathology suggesting its involvement in neurodegeneration.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.
See full target information NDRG4
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Immunology 172:588-599 PubMed38634546

2024

Oligodeoxynucleotides containing CpG motifs (CpG-ODN) restores immune regulatory functions of airway macrophages of patients with asthma.

Applications

Unspecified application

Species

Unspecified reactive species

Huanping Zhang,Lihuan Wang,Aizhi Zhang,Xiangyu Wang,Yun Liao,Xiaoxue Chen,Xuejie Xu,Litao Yang,Yu Liu,Aifa Tang,Pingchang Yang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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