Anti-Nebulette antibody

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This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Nebulette plays a pivotal role in organizing the actin cytoskeleton within cardiac myocytes. It forms part of the Z-disc complex and works closely with other structural proteins such as α-actinin and titin. Through these interactions Nebulette supports the mechanical stability of myofibrils. Its organization function is necessary to sustain proper muscle fiber contraction and overall cardiac function.

Pathways

Actin filament regulation and organization are influenced significantly by Nebulette. It integrates into the Calmodulin binding pathway where it interacts with proteins such as calmodulin itself to modulate cardiac muscle contraction. Moreover Nebulette is involved in the cardiac muscle contraction pathway where it collaborates with proteins such as MYH7 myosin heavy chain beta to support contractile unit performance.