JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB237798

Anti-NEGR1 antibody

Be the first to review this product! 리뷰 제출

|

(2 제품이 사용된 논문 )

Rabbit Polyclonal NEGR1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NEGR1 aa 1-200.

대체 명칭 보기

IGLON4, UNQ2433/PRO4993, NEGR1, Neuronal growth regulator 1, IgLON family member 4

3 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NEGR1 antibody (AB237798)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NEGR1 antibody (AB237798)

Paraffin-embedded human skeletal muscle tissue stained for NEGR1 using ab237798 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NEGR1 antibody (AB237798)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NEGR1 antibody (AB237798)

Paraffin-embedded human testis tissue stained for NEGR1 using ab237798 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-NEGR1 antibody (AB237798)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-NEGR1 antibody (AB237798)

PC-3 (human prostate adenocarcinoma cell line) cells stained for NEGR1 (green) using ab237798 at 1/100 dilution in ICC/IF, followed by Alexa Fluor® 488® conjugated Goat Anti-Rabbit IgG (H+L).

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human NEGR1 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q7Z3B1

style
left-column

대체품

Primary Antibodies

AB133676

Anti-NEGR1 antibody [EPR8713]

RabMAb|Recombinant

Western blot - Anti-NEGR1 antibody [EPR8713] (AB133676)

  • 0
  • 0

보완 제품

Primary Antibodies

AB217344

Anti-CD8 alpha antibody [EPR21769]

20ul selling size|RabMAb|Recombinant

Flow Cytometry - Anti-CD8 alpha antibody [EPR21769] (AB217344)

  • 5
  • 6
Primary Antibodies

AB109029

Anti-DCAMKL1 antibody [EPR6085]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DCAMKL1 antibody [EPR6085] (AB109029)

  • 5
  • 5
Primary Antibodies

AB283575

Anti-MMP9 antibody [RM1020]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated|Trial Size

Flow Cytometry (Intracellular) - Anti-MMP9 antibody [RM1020] (AB283575)

  • 0
  • 0
Primary Antibodies

AB219650

Anti-PRAME antibody [EPR20330]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PRAME antibody [EPR20330] (AB219650)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity greater than 95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

NEGR1 also known as Neuronal Growth Regulator 1 is a protein that plays an essential role in cellular adhesion and neurodevelopment. It carries a molecular mass of approximately 29 kDa. This protein shows expression mainly in the human brain particularly in regions such as the cortex and cerebellum. Studies have also detected NEGR1 in peripheral tissues to a lesser extent indicating a possible broader range of functions.
Biological function summary

NEGR1 contributes to neuronal growth and connectivity. It forms part of the immunoglobulin superfamily which includes proteins involved in the immune response and cell adhesion processes. NEGR1 interacts with cellular membranes through a glycosylphosphatidylinositol anchor facilitating cell-cell communication and signaling necessary for neural network formation. This interaction allows NEGR1 to be a part of synaptic development and plasticity affecting learning and memory processes.

Pathways

NEGR1 plays a part in neuronal growth pathways and synaptic signaling. These pathways are important for the development and maintenance of neuronal circuits. NEGR1 has connections to the MAPK pathway which oversees cell differentiation and proliferation. It interacts with other synaptic proteins like Neurexins and Neuroligins which are important for synaptic formation and stability underlining its integrative role in neural development.

NEGR1 has links to neurodevelopmental disorders and metabolic conditions. Research has identified associations between NEGR1 variants and autism spectrum disorders suggesting its impact on neural circuit wiring might influence these developmental conditions. Additionally NEGR1 appears related to obesity where it interacts with proteins like Leptin which regulates energy balance and body weight. These associations underline NEGR1's relevance in both neural and metabolic health.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).
See full target information NEGR1
style
left-column

제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of hepatocellular carcinoma 8:333-348 PubMed33977095

2021

LncRNA-CCDC144NL-AS1 Promotes the Development of Hepatocellular Carcinoma by Inducing WDR5 Expression via Sponging miR-940.

Applications

Unspecified application

Species

Unspecified reactive species

Yingying Zhang,Hongyu Zhang,Shuhuan Wu

Molecular therapy. Nucleic acids 22:815-831 PubMed33230478

2020

Circular RNA circRIMS1 Acts as a Sponge of miR-433-3p to Promote Bladder Cancer Progression by Regulating CCAR1 Expression.

Applications

Unspecified application

Species

Unspecified reactive species

Feifan Wang,Mengjing Fan,Yueshu Cai,Xuejian Zhou,Shengcheng Tai,Yanlan Yu,Hongshen Wu,Yan Zhang,Jiaxin Liu,Shihan Huang,Ning He,Zhenghui Hu,Xiaodong Jin
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com