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AB317393

Anti-NEK4 antibody [S09-1I1]

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Rabbit Recombinant Monoclonal NEK4 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human NEK4.

대체 명칭 보기

STK2, NEK4, Serine/threonine-protein kinase Nek4, Never in mitosis A-related kinase 4, Serine/threonine-protein kinase 2, Serine/threonine-protein kinase NRK2, NimA-related protein kinase 4

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

S09-1I1

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human NEK4.

P51957

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보완 제품

Primary Antibodies

AB279717

Anti-NEK2 antibody [20/NEK2]

Recombinant|KO Validated|Trial Size

Western blot - Anti-NEK2 antibody [20/NEK2] (AB279717)

  • 0
  • 0
Primary Antibodies

AB108521

Anti-ICAD antibody [EPR4222(2)]

RabMAb|Recombinant

Western blot - Anti-ICAD antibody [EPR4222(2)] (AB108521)

  • 0
  • 0
Primary Antibodies

AB151747

Anti-CDC42EP1 antibody [EPR10129(B)]

RabMAb|Recombinant

Western blot - Anti-CDC42EP1 antibody [EPR10129(B)] (AB151747)

  • 0
  • 0
Primary Antibodies

AB129075

Anti-MFF antibody [EPR7360]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-MFF antibody [EPR7360] (AB129075)

  • 0
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>" } } }
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제품 세부 정보

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
보관 버퍼
pH: 7.4 Preservative: 0.01% Sodium azide Constituents: 55.08% Water, 40% Glycerol (glycerin, glycerine), 0.98% Tris glycine, 0.88% Sodium chloride, 0.05% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

NEK4 also known as NimA-related protein kinase 4 functions as a serine/threonine kinase involved in cell cycle regulation and ciliogenesis. It has a molecular weight of about 84 kDa. NEK4 is expressed widely in various tissues with significant expression in lung skeletal muscle and kidney. Its expression is important for proper cellular processes like mitosis and maintenance of the ciliary structure.
Biological function summary

NEK4 participates in centrosome function and cilia dynamics playing an important role in maintaining cellular integrity. It associates with other proteins in a complex manner to facilitate cell cycle progression. NEK4 shows importance in regulating the stability of microtubules which affects the proper formation and function of cilia.

Pathways

NEK4 integrates into major cellular pathways involved in cell cycle checkpoints and ciliogenesis. It is a part of the cell cycle regulation pathway influencing events necessary for DNA replication and mitotic progression. NEK4 also interacts with proteins like NEK1 which further modulates its activity in regulating cellular responses to DNA damage and ensuring correct cell division.

NEK4 links to conditions such as cancer and primary ciliary dyskinesia. In various cancers NEK4 expression may influence tumor growth and metastasis through its role in cell cycle regulation. In primary ciliary dyskinesia faults in NEK4-related proteins like NEK1 can affect cilia structure and function leading to clinical symptoms.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage.
See full target information NEK4
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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