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AB69226

Anti-NETO1 antibody

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(1 출판물)

Mouse Polyclonal NETO1 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NETO1.

주요 정보

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human NETO1.

Q8TDF5

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보완 제품

Proteins & Peptides

AB276405

Recombinant Human NETO1 protein (His tag)

SDS-PAGE - Recombinant Human NETO1 protein (His tag) (AB276405)

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Primary Antibodies

AB155772

Anti-KCNG4 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KCNG4 antibody (AB155772)

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Primary Antibodies

AB76199

Anti-eNOS (phospho S632) antibody [M232]

Western blot - Anti-eNOS (phospho S632) antibody [M232] (AB76199)

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Primary Antibodies

AB229581

Anti-ULK1 (phospho S758) antibody

  • 1
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.4 Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The NETO1 protein also known as Neuropilin and Tolloid-like 1 is a transmembrane protein with a molecular weight of about 75 kDa. It is primarily expressed in the central nervous system particularly in the hippocampus and cerebellum. NETO1 serves as an auxiliary subunit of ionotropic glutamate receptors specifically the kainate receptor. It modulates the receptor's function by enhancing its kinetics and gating critical for synaptic transmission and plasticity.
Biological function summary

The protein interacts with kainate receptors forming a functional receptor complex that aids in neurotransmission processes. The complex plays a significant role in synaptic scaling and has implications for learning and memory functions. NETO1's ability to bind to various ligands on the glutamate receptor ensures its engagement in critical signal transduction activities across neuronal synapses.

Pathways

The function of NETO1 integrates into neurotransmission and synaptic plasticity pathways. NETO1 plays an important role in the glutamatergic synaptic transmission pathway alongside proteins like the GLUR5 receptor subunit. This involvement facilitates efficient communication between neurons influencing long-term potentiation and depression which are central to learning and memory processes.

NETO1's dysfunction associates with neurological and psychiatric conditions such as schizophrenia and epilepsy. Altered expression or mutations in NETO1 can impact the signaling pathway affecting synaptic strength and neuronal communication. It also interacts with proteins such as DLG4 also known as PSD-95 in these conditions further implicating NETO1 in the stability and function of postsynaptic densities potentially leading to cognitive and behavioral abnormalities.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity).
See full target information NETO1

대체 명칭 보기

BTCL1, NETO1, Neuropilin and tolloid-like protein 1, Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

PloS one 9:e90952 PubMed24632577

2014

Hypoxia-inducible MiR-210 is an independent prognostic factor and contributes to metastasis in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ailin Qu,Lutao Du,Yongmei Yang,Hui Liu,Juan Li,Lili Wang,Yimin Liu,Zhaogang Dong,Xin Zhang,Xiumei Jiang,Haiyan Wang,Zewu Li,Guixi Zheng,Chuanxin Wang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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