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AB235145

Anti-NeuroD1 antibody

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(1 출판물)

Goat Polyclonal NeuroD1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

대체 명칭 보기

BHLHA3, NEUROD, NEUROD1, Neurogenic differentiation factor 1, NeuroD, NeuroD1, Class A basic helix-loop-helix protein 3, bHLHa3

1 이미지
Western blot - Anti-NeuroD1 antibody (AB235145)
  • WB

Supplier Data

Western blot - Anti-NeuroD1 antibody (AB235145)

All lanes:

Western blot - Anti-NeuroD1 antibody (ab235145) at 5 µg/mL

Lane 1:

NeuroD1 recombinant protein (50 ng), spiked in HEK-293 lysate at 35 µg

Lane 2:

HEK-293 lysate at 35 µg

Lane 3:

SCLC-21H whole cell lysate at 35 µg

Predicted band size: 40 kDa

false

주요 정보

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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대체품

Primary Antibodies

AB213725

Anti-NeuroD1 antibody [EPR20766]

20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-NeuroD1 antibody [EPR20766] (AB213725)

  • 4
  • 2
Primary Antibodies

AB205300

Anti-NeuroD1 antibody [EPR17084]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-NeuroD1 antibody [EPR17084] (AB205300)

  • 0
  • 0
Primary Antibodies

AB109224

Anti-NeuroD1 antibody [EPR4008]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-NeuroD1 antibody [EPR4008] (AB109224)

  • 5
  • 1
Primary Antibodies

AB239955

Anti-NeuroD1 antibody [EPR4008] - BSA and Azide free

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-NeuroD1 antibody [EPR4008] - BSA and Azide free (AB239955)

  • 0
  • 0
Primary Antibodies

AB236148

Anti-NeuroD1 antibody [EPR17084] - BSA and Azide free

BOND RX™ Validated|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-NeuroD1 antibody [EPR17084] - BSA and Azide free (AB236148)

  • 0
  • 0
Primary Antibodies

AB226489

Anti-NeuroD1 antibody [EPR20766] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-NeuroD1 antibody [EPR20766] - BSA and Azide free (AB226489)

  • 0
  • 0

보완 제품

Primary Antibodies

AB211327

Anti-MASH1/Achaete-scute homolog 1 antibody [EPR19840]

BOND RX™ Validated|RabMAb|Recombinant|Advanced Validation|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MASH1/Achaete-scute homolog 1 antibody [EPR19840] (AB211327)

  • 4
  • 3
Primary Antibodies

AB183734

Anti-GFP antibody [EPR14104]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFP antibody [EPR14104] (AB183734)

  • 5
  • 24
Primary Antibodies

AB6326

Anti-BrdU antibody [BU1/75 (ICR1)] - Proliferation Marker

Flow Cytometry (Intracellular) - Anti-BrdU antibody [BU1/75 (ICR1)] - Proliferation Marker (AB6326)

  • 5
  • 104
Primary Antibodies

AB240636

Anti-Ctip2 antibody [EPR23120-25]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Flow Cytometry (Intracellular) - Anti-Ctip2 antibody [EPR23120-25] (AB240636)

  • 5
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "5 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
보관 버퍼
Preservative: 0.01% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

NeuroD1 also referred to as Neurogenic Differentiation 1 is a basic helix-loop-helix transcription factor with a molecular mass of approximately 40 kDa. This protein is expressed mainly in the central nervous system as well as in the pancreas. NeuroD1 plays a role in activating transcription by binding to DNA sequences in specific target genes. This process involves dimerization with E proteins facilitating its function as a transcriptional activator.
Biological function summary

NeuroD1 influences neural development and differentiation. It is vital in converting undifferentiated neural precursors into mature neurons ensuring proper brain formation. NeuroD1 forms part of a transcriptional complex with other neural transcription factors which coordinates the expression of genes needed for neuron specification. Apart from neurogenesis it regulates insulin gene expression in pancreatic beta cells linking neural functions to endocrine regulation.

Pathways

NeuroD1 functions in the neurogenesis pathway and interacts closely with the Notch signaling pathway. It plays a role by influencing the expression of genes essential for neuronal lineage commitment. In the insulin signaling pathway NeuroD1 cooperates with other transcription factors like Pdx1 and MafA managing the expression of insulin and other important beta-cell genes. Interactions with proteins like E47 increase its regulatory effects on these pathways.

Defects in NeuroD1 function connect to conditions such as diabetes mellitus and medulloblastoma. In diabetes mellitus NeuroD1 mutations can disturb insulin gene regulation impacting glucose metabolism severely. The connection with Pdx1 further magnifies its involvement in pancreatic beta-cell function. In medulloblastoma aberrant expression or mutations in NeuroD1 affect neuronal differentiation leading to tumor development. NeuroD1 influences cellular pathways interacting with proteins such as Sox9 which contributes to oncogenic processes in neural tissues.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Acts as a transcriptional activator : mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).
See full target information NEUROD1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Communications biology 8:1249 PubMed40830221

2025

A robust method for assessing mitochondrial function in healthy and diseased frozen cardiac tissue.

Applications

Unspecified application

Species

Unspecified reactive species

Liangyu Hu,Alexia van Rinsum,Rocco Caliandro,Xi Qi,Shuxiu Fan,Xinyi Jiang,Jur Massop,Melissa Bekkenkamp-Grovenstein,Christiane Ott,Tilman Grune,Melissa A E van de Wal,Werner J H Koopman,Marcel Giesbers,Monika Gladka,Jaap Keijer,Deli Zhang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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