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AB269711

Anti-Neurotensin Receptor 1/NTSR1 antibody [B-N6] - BSA and Azide free

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Mouse Monoclonal Neurotensin Receptor 1/NTSR1 antibody. Carrier free. Suitable for Flow Cyt and reacts with Transfected cell line - Human samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing NTSR1 protein.

대체 명칭 보기

NTRR, NTSR1, Neurotensin receptor type 1, NT-R-1, NTR1, High-affinity levocabastine-insensitive neurotensin receptor, NTRH

1 이미지
Flow Cytometry - Anti-Neurotensin Receptor 1/NTSR1 antibody [B-N6] - BSA and Azide free (AB269711)
  • Flow Cyt

Unknown

Flow Cytometry - Anti-Neurotensin Receptor 1/NTSR1 antibody [B-N6] - BSA and Azide free (AB269711)

Staining pattern of NTR transfected CHO cell line with ab27380.This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (ab27380)

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

B-N6

Isotype

IgM

Light chain 타입

kappa

Carrier free

Yes

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing NTSR1 protein. The exact immunogen used to generate this antibody is proprietary information.

P30989

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대체품

Primary Antibodies

AB183088

Anti-Neurotensin Receptor 1/NTSR1 antibody

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Primary Antibodies

AB217134

Anti-Neurotensin Receptor 1/NTSR1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Neurotensin Receptor 1/NTSR1 antibody (AB217134)

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보완 제품

Primary Antibodies

AB18401

Mouse IgM, kappa monoclonal [MM-30] - isotype control

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Primary Antibodies

AB236285

Anti-GPCR GPR40 antibody

Immunocytochemistry/ Immunofluorescence - Anti-GPCR GPR40 antibody (AB236285)

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Secondary Antibodies

AB150121

Goat Anti-Mouse IgM mu chain (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgM mu chain (Alexa Fluor® 488) (AB150121)

  • 5
  • 5
Proteins & Peptides

AB224777

Recombinant Human Neurotensin protein (His tag C-Terminus)

SDS-PAGE - Recombinant Human Neurotensin protein (His tag C-Terminus) (AB224777)

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  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "" }, "Transfected cell line - Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "10 µL for 10^6 Cells", "FlowCyt-species-notes": "<p><a href='/ko/products/primary-antibodies/mouse-igm-b11-7-isotype-control-ab91545'>ab91545</a> - Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody.</p>" } } }
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제품 세부 정보

ab269711 is a carrier free version of ab27380.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

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특성 및 보관 정보

제형
Liquid
Purification 관련 사항
Gel filtration
보관 버퍼
pH: 7.3 - 7.5 Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Neurotensin Receptor 1 also known as NTSR1 functions as a G-protein coupled receptor (GPCR) that binds to the neuropeptide neurotensin. This protein consists of seven transmembrane domains typical of GPCRs and has a molecular mass of roughly 46 kDa. NTSR1 commonly expresses in the central nervous system particularly in the brain regions such as hypothalamus and basal ganglia and also in peripheral tissues like the gastrointestinal tract.
Biological function summary

NTSR1 influences signaling cascades that regulate various physiological processes. It forms part of a receptor-ligand complex with neurotensin a peptide that modulates neurotransmission and hormone regulation. Neurotensin and NTSR1 interaction can affect neurotransmitter release modulating pathways related to pain locomotion and thermoregulation. Researchers have observed significant roles of the receptor in neural proliferation as well.

Pathways

NTSR1 acts significantly in the dopaminergic and phosphatidylinositol signaling pathways. In the dopaminergic system NTSR1 interacts with dopamine D2 receptors influencing dopamine-mediated behaviors and responses. In phosphatidylinositol signaling it regulates downstream effectors like protein kinase C impacting cellular responses. These pathways integrate NTSR1 into broader signaling networks that control critical neuronal functions and responses.

NTSR1 has connections to certain neurological and psychiatric disorders such as schizophrenia and Parkinson's disease. Abnormal NTSR1 signaling affects dopaminergic neurotransmission which highlights its role in these conditions. Altered interactions with proteins like the dopamine D2 receptor contribute to the pathological symptoms observed in these diseases. Research into NTSR1 and its pathways may reveal targets for therapeutic intervention.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed : 21725197, PubMed : 23140271, PubMed : 8381365). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed : 21725197).
See full target information NTSR1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Scientific reports 13:4663 PubMed36949141

2023

NTSR1 glycosylation and MMP dependent cleavage generate three distinct forms of the protein.

Applications

Unspecified application

Species

Unspecified reactive species

Fotine Libanje,Raphael Delille,Pamela A Young,Sylvie Rolland,Florence Meyer-Losic,Elodie Lewkowicz,Stephan Klinz
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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