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AB247146

Anti-NKG2E antibody

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(1 출판물)

Rabbit Polyclonal NKG2E antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KLRC3 aa 200-250.

대체 명칭 보기

NKG2E, KLRC3, NKG2-E type II integral membrane protein, NK cell receptor E, NKG2-E-activating NK receptor

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NKG2E antibody (AB247146)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NKG2E antibody (AB247146)

Paraffin-embedded human tonsil tissue stained for NKG2E using ab247146 at 1/20 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human KLRC3 aa 200-250. The exact immunogen used to generate this antibody is proprietary information.

Q07444

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보완 제품

Primary Antibodies

AB224699

Anti-NKG2A + NKG2E + NKG2C antibody [EPR22137]

20ul selling size|RabMAb|Recombinant|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NKG2A + NKG2E + NKG2C antibody [EPR22137] (AB224699)

  • 0
  • 0
Primary Antibodies

AB235441

Anti-CD94 antibody [EPR21003]

20ul selling size|RabMAb|Recombinant|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD94 antibody [EPR21003] (AB235441)

  • 4
  • 1
Primary Antibodies

AB302907

Anti-NKG2D antibody [EPR24072-342]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Immunohistochemistry - Anti-NKG2D antibody [EPR24072-342] (AB302907)

  • 0
  • 0
Primary Antibodies

AB230900

Anti-NKG2C antibody - N-terminal

Flow Cytometry (Intracellular) - Anti-NKG2C antibody - N-terminal (AB230900)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

NKG2E also known as KLRC3 is a protein involved in immune response regulation. It belongs to the killer cell lectin-like receptor subfamily K (NKG2) and has a predicted mass of approximately 25 kDa. NKG2E is primarily expressed on natural killer (NK) cells and some T cell subsets. This expression is important for these cells' ability to recognize and eliminate infected or malignant cells. NKG2E operates through interactions with other proteins and may form complexes to mediate immune signaling.
Biological function summary

NKG2E interacts with other components on cellular surfaces to play a role in activating immune cell responses. It often forms complexes with the adapter protein DAP12 which contains immunoreceptor tyrosine-based activation motifs (ITAMs). This interaction leads to the triggering of downstream signaling cascades upon recognition of stress-induced ligands on infected or tumor cells. The result is increased cytotoxicity and cytokine production which contribute to immune surveillance.

Pathways

NKG2E is significant in immune checkpoint pathways that regulate the balance between immune activation and tolerance. It is linked with the Natural Killer cell mediated cytotoxicity pathway and interacts with HLA class I ligands. NKG2E's association with other proteins such as NKG2D and CD94 exists within these pathways serving to modulate the activation threshold and function of NK cells and certain T cells therefore maintaining immune homeostasis.

NKG2E shows connections to cancer and viral infections where immune evasion mechanisms need counteracting. Tumor cells sometimes alter the expression of ligands that engage NKG2E influencing the effectiveness of NK cell surveillance. In viral infections NKG2E's role in recognizing stress-induced ligands supports defense against pathogens like cytomegalovirus (CMV). The protein's connection with the adapter protein DAP12 is instrumental in these immune responses and may highlight potential therapeutic strategies targeting immune modulation.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
See full target information KLRC3
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Scientific reports 15:13811 PubMed40259011

2025

Human RCC1L is involved in the maintenance of mitochondrial nucleoids and mtDNA.

Applications

Unspecified application

Species

Unspecified reactive species

Emi Matsumoto,Taeko Sasaki,Tetsuya Higashiyama,Narie Sasaki
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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