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AB52184

Anti-NMDAR1 (phospho S897) antibody

1

(3 리뷰들)

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(2 제품이 사용된 논문 )

Rabbit Polyclonal NMDAR1 phospho S897 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human GRIN1 pS897 aa 850 to C-terminus.
2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMDAR1 (phospho S897) antibody (AB52184)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMDAR1 (phospho S897) antibody (AB52184)

ab52184 at 1/50 dilution staining Human brain tissue with and without blocking peptide; paraffin embedded.

Western blot - Anti-NMDAR1 (phospho S897) antibody (AB52184)
  • WB

Supplier Data

Western blot - Anti-NMDAR1 (phospho S897) antibody (AB52184)

Western Blot analysis of LOVO cell lysate labeling NMDAR1 (phospho S897) with ab52184. The lane on the right is blocked with the phospho peptide.

All lanes:

Western blot - Anti-NMDAR1 (phospho S897) antibody (ab52184)

Predicted band size: 105 kDa

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주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human GRIN1 pS897 aa 850 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q05586

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대체품

Primary Antibodies

AB109182

Anti-NMDAR1 antibody [EPR2481(2)] - Neuronal Marker

20ul selling size|KO Validated|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-NMDAR1 antibody [EPR2481(2)] - Neuronal Marker (AB109182)

  • 4
  • 4
Primary Antibodies

AB68144

Anti-NMDAR1 antibody [EPR2480Y] - Neuronal Marker

RabMAb|Recombinant|Lab Essentials|20ul selling size

Western blot - Anti-NMDAR1 antibody [EPR2480Y] - Neuronal Marker (AB68144)

  • 0
  • 0
Primary Antibodies

AB236041

Anti-NMDAR1 antibody [EPR2480Y] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-NMDAR1 antibody [EPR2480Y] - BSA and Azide free (AB236041)

  • 0
  • 0
Primary Antibodies

AB193310

Anti-NMDAR1 antibody [N308/48] - Neuronal Marker

BOND RX™ Validated|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMDAR1 antibody [N308/48] - Neuronal Marker (AB193310)

  • 0
  • 0
Primary Antibodies

AB239949

Anti-NMDAR1 antibody [EPR2481(2)] - BSA and Azide free

KO Validated|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-NMDAR1 antibody [EPR2481(2)] - BSA and Azide free (AB239949)

  • 0
  • 0

보완 제품

Primary Antibodies

AB75680

Anti-NMDAR1 (phospho S896) antibody

Western blot - Anti-NMDAR1 (phospho S896) antibody (AB75680)

  • 0
  • 0
Primary Antibodies

AB109182

Anti-NMDAR1 antibody [EPR2481(2)] - Neuronal Marker

20ul selling size|KO Validated|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-NMDAR1 antibody [EPR2481(2)] - Neuronal Marker (AB109182)

  • 4
  • 4
Primary Antibodies

AB65783

Anti-NMDAR2B antibody

Western blot - Anti-NMDAR2B antibody (AB65783)

  • 4
  • 5
Primary Antibodies

AB307359

Anti-GABA A Receptor alpha 2/GABRA2 antibody [EPR26485-185]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-GABA A Receptor alpha 2/GABRA2 antibody [EPR26485-185] (AB307359)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

NMDAR1 also known as GluN1 is a subunit of the NMDA receptor a type of ion channel protein found in the brain. This receptor weighs around 120 kDa and plays an important role in synaptic transmission and plasticity. NMDAR1 operates as part of a receptor complex that allows for calcium influx when activated. It shows high expression throughout the central nervous system primarily in neurons across the cortex and hippocampus. The receptor's function is important to certain calcium-dependent processes in the brain.
Biological function summary

NMDA receptors including the NMDAR1 subunit serve essential functions in synaptic plasticity and memory processes. As part of the receptor complex NMDAR1 contributes to the control of synaptic strength. It requires co-activation by glutamate and glycine or D-serine linking its function to excitatory neurotransmission. The receptor's capacity to modulate synaptic connections forms the basis of learning and long-term memory.

Pathways

NMDAR1 plays a critical role in the glutamatergic pathway influencing synaptic plasticity and memory function. It interacts with other proteins like PSD-95 within the postsynaptic density. NMDAR1 is also involved in the calcium signaling pathway due to its ability to facilitate calcium entry into neurons upon synaptic activity. This positions the receptor as an important modulator in pathways that control neuronal communication and plasticity.

NMDA receptor dysfunction including the NMDAR1 subunit links to neurodegenerative diseases such as Alzheimer's. The alterations in NMDAR1 function can lead to excitotoxicity contributing to neuronal damage. NMDAR1 also associates with schizophrenia where altered glutamatergic transmission has been observed. Here abnormalities in proteins like the synaptic scaffolding protein PSD-95 have also been noted to relate to NMDAR1 dysfunction in the pathophysiology of these disorders.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed : 21376300, PubMed : 26875626, PubMed : 26919761, PubMed : 28126851, PubMed : 28228639, PubMed : 36959261, PubMed : 7679115, PubMed : 7681588, PubMed : 7685113). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP) (PubMed : 26875626). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed : 21376300, PubMed : 26875626, PubMed : 26919761, PubMed : 27164704, PubMed : 28095420, PubMed : 28105280, PubMed : 28126851, PubMed : 28228639, PubMed : 36959261, PubMed : 38538865, PubMed : 7679115, PubMed : 7681588, PubMed : 7685113). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed : 26875626, PubMed : 26919761, PubMed : 36309015, PubMed : 38598639).
See full target information GRIN1 pS897

대체 명칭 보기

NMDAR1, GRIN1, GluN1, Glutamate [NMDA] receptor subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1, NMD-R1, hNR1
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Neuropharmacology 189:108533 PubMed33744339

2021

cAMP signaling through protein kinase A and Epac2 induces substance P release in the rat spinal cord.

Applications

Unspecified application

Species

Unspecified reactive species

Wenling Chen,James A McRoberts,Helena S Ennes,Juan Carlos Marvizon

PloS one 7:e35024 PubMed22496886

2012

Olfactory bulb glomerular NMDA receptors mediate olfactory nerve potentiation and odor preference learning in the neonate rat.

Applications

IHC-FoFr

Species

Rat

Rebecca Lethbridge,Qinlong Hou,Carolyn W Harley,Qi Yuan
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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