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AB197686

Anti-NME6 antibody

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Rabbit Polyclonal NME6 antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NME6.

대체 명칭 보기

NDK6, NDP kinase 6, Inhibitor of p53-induced apoptosis-alpha, nm23-H6, IPIA-alpha, NME6

1 이미지
Western blot - Anti-NME6 antibody (AB197686)
  • WB

Supplier Data

Western blot - Anti-NME6 antibody (AB197686)

10% SDS-PAGE

All lanes:

Western blot - Anti-NME6 antibody (ab197686) at 1/400 dilution

Lane 1:

Mouse spleen tissue lysate at 40 µg

Lane 2:

Mouse intestinum crassum tissue lysate at 40 µg

Predicted band size: 21 kDa

false

Exposure time: 1min

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human NME6.

O75414

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보완 제품

Primary Antibodies

AB92552

Anti-PCNA antibody [EPR3821]

RabMAb|Lab Essentials|20ul selling size|Recombinant

Flow Cytometry (Intracellular) - Anti-PCNA antibody [EPR3821] (AB92552)

  • 5
  • 12
Primary Antibodies

AB40658

Anti-p73 antibody [EP436Y]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-p73 antibody [EP436Y] (AB40658)

  • 5
  • 3
Primary Antibodies

AB193598

HRP Anti-Cyclin A2 antibody [E399]

RabMAb|Recombinant

Western blot - HRP Anti-Cyclin A2 antibody [E399] (AB193598)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

NME6 also known as NM23-H6 or NDP kinase H6 is an enzyme that plays a role as a nucleoside diphosphate kinase. It weighs approximately 19 kDa and is part of the NME/NM23 nucleoside diphosphate kinase gene family. NME6 appears in various tissues with notable expression in the heart and skeletal muscle indicating its importance in tissues with high energy demands.
Biological function summary

NME6 functions in regulating the levels of nucleoside triphosphates within cells. The enzyme does not act alone; it associates as part of a larger complex where its activity supplements cellular energy metabolism. This involvement in energy conversion underlines its broader role in maintaining the balance of ATP and GTP concentrations which are essential for numerous cellular processes including signal transduction and cell proliferation.

Pathways

The enzyme NME6 integrates into ATP synthesis and metabolism pathways. It holds a relationship with the ATP citrate lyase pathway facilitating the interplay of energy production and consumption. Through this connection NME6 interacts with proteins such as NME1 and NME2 which also participate in maintaining cellular energetic homeostasis.

Alterations in the NME6 function have associations with mitochondrial disorders particularly those impacting tissues with high energetic needs. The enzyme also relates to cardiovascular diseases due to its expression in the cardiac muscle. Defective NME6 expression or function might cause disruptions in energy homeostasis leading to disease states. Additionally through these diseases NME6 potentially connects to other proteins involved in energy metabolism like ATP synthase.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Catalytic subunit of a complex with RCC1L, which catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving the formation of a phosphohistidine intermediate (PubMed : 10618642, PubMed : 34789336, PubMed : 37770567). Participates in the regulation of mitochondrial nucleotide levels, mitoribosome biogenesis, and mitochondrial RNA abundances (PubMed : 10618642, PubMed : 34789336, PubMed : 37770567). Supplies pyrimidine ribonucleoside triphosphates (rNTPs) for mitochondrial transcription and is required for the maintenance of mitochondrial DNA (mtDNA) when the import of pyrimidine deoxyribonucleoside triphosphates (dNTPs) is limited from the cytosol is limited (PubMed : 37439264). As a monomer, lacks nucleoside diphosphate kinase (NDPK) activity (PubMed : 34789336).
See full target information NME6
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of cellular and molecular medicine 25:1759-1770 PubMed33452764

2021

Exploring the five different genes associated with PKCα in bladder cancer based on gene expression microarray.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaotong Zhang,Jiarun Zhang,Hao Zhang,Yang Liu,Lei Yin,Xi Liu,Xuejie Li,Xiuyue Yu,Jinlong Yao,Zhe Zhang,Chuize Kong
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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