AB239520

Anti-Noggin antibody [A11]

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(3 제품이 사용된 논문 )

Mouse Monoclonal Noggin antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NOG.

대체 명칭 보기

Noggin, NOG

6 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Noggin antibody [A11] (AB239520)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Noggin antibody [A11] (AB239520)

Paraffin-embedded human pancreatic cancer tissue stained for Noggin with ab239520 at 30 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Noggin antibody [A11] (AB239520)

Paraffin-embedded human breast cancer tissue stained for Noggin with ab239520 at 30 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Noggin antibody [A11] (AB239520)

Paraffin-embedded human liver cancer tissue stained for Noggin with ab239520 at 30 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Noggin antibody [A11] (AB239520)

Paraffin-embedded human glioma tissue stained for Noggin with ab239520 at 30 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-Noggin antibody [A11] (AB239520)

All lanes:

Western blot - Anti-Noggin antibody [A11] (ab239520) at 2 µg/mL

All lanes:

Recombinant human Noggin protein

Secondary

All lanes:

HRP-Linked Rabbit Anti-Mouse IgG at 1/5000 dilution

Predicted band size: 26 kDa

false

Supplier Data

Western blot - Anti-Noggin antibody [A11] (AB239520)

All lanes:

Western blot - Anti-Noggin antibody [A11] (ab239520) at 2 µg/mL

All lanes:

Rat placenta lysate

Secondary

All lanes:

HRP-Linked Rabbit Anti-Mouse IgG at 1/5000 dilution

Predicted band size: 26 kDa

false

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

A11

Isotype

IgG2b

Light chain 타입

kappa

Carrier free

Reacts with

Rat, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human NOG.

Q13253

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-30 µg/mL", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A/G

Purification 관련 사항

Purified from TCS.

보관 버퍼

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Noggin also known as noggin protein is a secreted glycoprotein with a mass of approximately 26 kDa. It antagonizes bone morphogenetic proteins (BMPs) by directly binding them preventing their interaction with receptors. This binding inhibits the signaling pathway which affects cellular processes such as differentiation growth and apoptosis. Noggin expresses prominently in embryonic tissues and in tissues undergoing differentiation particularly in the neural tube notochord and developing articular cartilage. The expression pattern suggests its importance during critical phases of development and tissue patterning.

Biological function summary

Noggin functions as an essential regulator in embryonic development sculpting tissues by inhibiting BMP activity. It does not work alone but functions as part of a complex regulatory network involving other BMP antagonists. By inhibiting BMPs Noggin plays an important role in neural tube closure limb formation and somite development. Noggin's activities help modulate the balance between proliferation and differentiation in these contexts allowing for proper structural formation during embryogenesis.

Pathways

Noggin operates mainly within the TGF-beta/BMP signaling pathway serving as a critical modulator. Inhibiting BMP through Noggin affects downstream targets connecting it to other signaling proteins like SMADs which mediate transcriptional responses. This control enables Noggin to indirectly regulate Wnt signaling as well showing its impact on various developmental stages and processes. Its influence on these pathways indicates Noggin’s importance in maintaining cellular homeostasis during growth and morphogenesis.

Noggin relates to conditions such as fibrodysplasia ossificans progressiva and cartilage-related abnormalities. Mutations or dysregulation of noggin protein can disrupt normal BMP signaling leading to aberrant skeletal development and calcification. This disruption often involves interactions with other proteins like BMP4 revealing Noggin's critical role in maintaining bone and cartilage integrity. Targeting noggin pathway components may provide therapeutic potential for addressing such conditions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (PubMed : 21976273, PubMed : 26643732).

See full target information NOG

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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Scientific reports 15:33150 PubMed41006496

2025

Neonatal sevoflurane exposure enhances stress-related neurological susceptibility via NKCC1 modulation.

Applications

Unspecified application

Species

Unspecified reactive species

Bi-Ying Yuan,Li-Hui Shan,Jiang Zou,Xiao-Hai Xie,Jia-Qi Gan,Ben-Zhen Chen

Cardiovascular research 120:2163-2165 PubMed39238367

2024

Identifying optimal reference genes for real-time quantitative polymerase chain reaction in human myocardial tissues.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Camacho-Encina,Laura K Booth,Rachael Redgrave,Minna Honkanen-Scott,William E Scott,Carmen Martin-Ruiz,Guy MacGowan,Sarah Richardson,John Dark,Simon Tual-Chalot,Gavin D Richardson

International journal of molecular medicine 51: PubMed36524372

2022

Activin A rescues preterm brain injury through a novel Noggin/BMP4/Id2 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaojuan Su,Junjie Ying,Dongqiong Xiao,Xia Qiu,Shiping Li,Fengyan Zhao,Jun Tang

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Noggin antibody [A11]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Noggin antibody [A11] (AB239520)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Noggin antibody [A11] (AB239520)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Noggin antibody [A11] (AB239520)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Noggin antibody [A11] (AB239520)

Western blot - Anti-Noggin antibody [A11] (AB239520)

Western blot - Anti-Noggin antibody [A11] (AB239520)

주요 정보

Host species

Clonality

Clone number

Isotype

Light chain 타입

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

Primary Antibodies

보완 제품

Assay Kits

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (3)

Product promise