AB172653

Anti-Nogo Receptor antibody

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Mouse Polyclonal Nogo Receptor antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RTN4R.

대체 명칭 보기

NOGOR, UNQ330/PRO526, RTN4R, Reticulon-4 receptor, Nogo receptor, Nogo-66 receptor, NgR

1 이미지

Supplier Data

Western blot - Anti-Nogo Receptor antibody (AB172653)

All lanes:

Western blot - Anti-Nogo Receptor antibody (ab172653) at 1 µg/mL

Lane 1:

Nogo Receptor-transfected 293T cell line lysate at 15 µL

Lane 2:

Non-transfected 293T cell line lysate at 15 µL

Secondary

All lanes:

Goat Anti-Mouse IgG-HRP at 1/2500 dilution

Predicted band size: 51 kDa

true

주요 정보

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Recombinant Full Length Protein corresponding to Human RTN4R.

Q9BZR6

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cynomolgus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.4 Constituents: PBS

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The Nogo Receptor also known as Reticulon 4 receptor (RTN4R) is a protein that functions as an axon growth inhibitor. This receptor with an approximate molecular mass of 55 kDa binds to myelin-associated inhibitors to regulate neuronal growth and regeneration. It is part of the Nogo signaling pathway and is expressed mainly in the central nervous system. The receptor interacts with ligands like Nogo-A MAG and OMgp which play key roles in the restriction of axonal regeneration.

Biological function summary

Nogo Receptor plays a critical role in the regulation of neural plasticity and axonal growth. The receptor forms a complex with co-receptors such as p75 neurotrophin receptor (p75NTR) and LINGO-1 and this complex significantly influences signal transduction. Nogo Receptor-mediated signaling restricts the ability of neurons to regrow or extend after injury maintaining inhibitory influence on the nervous system regeneration.

Pathways

This receptor actively participates in neural inhibitory signaling and axon guidance pathways. It integrates signals from proteins like Nogo-A and glial inhibitors to regulate neuron morphology and network architecture. Understanding these pathways reveals Nogo Receptor's involvement in neuronal development and injury responses associating with signaling proteins like ROCK that mediate structural rearrangement of the cytoskeleton.

Nogo Receptor has relevance particularly in central nervous system injuries and multiple sclerosis (MS). Its high expression in the CNS aligns with limited neural repair and recovery in these conditions. Nogo Receptor signaling inhibits axonal regeneration contributing to the pathology of diseases like spinal cord injury and MS. In multiple sclerosis interactions between Nogo Receptor and MAG or OMgp correspond with the restricted repair and remyelination processes observed in demyelinating lesions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Receptor for RTN4, OMG and MAG (PubMed : 12037567, PubMed : 12068310, PubMed : 12089450, PubMed : 12426574, PubMed : 12839991, PubMed : 16712417, PubMed : 18411262, PubMed : 19052207). Functions as a receptor for the sialylated gangliosides GT1b and GM1 (PubMed : 18411262). Besides, functions as a receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR (PubMed : 12426574). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed : 16712417, PubMed : 22325200). Mediates axonal growth inhibition (PubMed : 12839991, PubMed : 19052207, PubMed : 28892071). Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed : 22325200).. (Microbial infection) Acts as a receptor for Reovirus type 3.

See full target information RTN4R

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The Journal of biological chemistry 300:107988 PubMed39542244

2024

Absence of SMARCB1 in rhabdoid tumor cells increases sensitivity to translation inhibition and alters translation efficiency of specific mRNAs.

Applications

Unspecified application

Species

Unspecified reactive species

Linh T Nguyen,Anastasia E Hains,Mohammad O Aziz-Zanjani,Mattia Dalsass,Sheikh B U D Farooqee,Yingzhou Lu,Peter K Jackson,Capucine Van Rechem

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Nogo Receptor antibody

Western blot - Anti-Nogo Receptor antibody (AB172653)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Assay Kits

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise