JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB192313

Anti-NRXN3 antibody

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Rabbit Polyclonal NRX3A antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human NRXN3.

대체 명칭 보기

C14orf60, KIAA0743, NRXN3, Neurexin-3, Neurexin III-alpha, Neurexin-3-alpha

1 이미지
Western blot - Anti-NRXN3 antibody (AB192313)
  • WB

Supplier Data

Western blot - Anti-NRXN3 antibody (AB192313)

All lanes:

Western blot - Anti-NRXN3 antibody (ab192313)

Lane 1:

HeLa whole cell lysate

Lane 2:

Raw264.7 whole cell lysate

Lane 3:

H9C2 whole cell lysate

Predicted band size: 181 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human NRXN3. The exact immunogen used to generate this antibody is proprietary information.

Q9Y4C0

style
left-column

보완 제품

Assay Kits

AB313913

Human NRXN3 ELISA Kit

Sandwich ELISA - Human NRXN3 ELISA Kit (AB313913)

  • 0
  • 0
Primary Antibodies

AB251161

Anti-Neuroligin 3 antibody [EPR16158] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-Neuroligin 3 antibody [EPR16158] - BSA and Azide free (AB251161)

  • 0
  • 0
Primary Antibodies

AB222806

Anti-Neurexin I beta antibody

Immunocytochemistry/ Immunofluorescence - Anti-Neurexin I beta antibody (AB222806)

  • 0
  • 0
Primary Antibodies

AB186279

Anti-Neuroligin 1 antibody [N97A/31]

Immunocytochemistry/ Immunofluorescence - Anti-Neuroligin 1 antibody [N97A/31] (AB186279)

  • 0
  • 0
Primary Antibodies

AB316740

Anti-NLGN4 antibody [EPR26331-43]

20ul selling size|Recombinant|RabMAb|Trial Size

Western blot - Anti-NLGN4 antibody [EPR26331-43] (AB316740)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
Purity is > 95% (by SDS-PAGE).
보관 버퍼
pH: 7.2 Preservative: 0.05% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Neurexin 3 also known as NRXN3 is a member of the neurexin family of synaptic cell adhesion molecules. It weighs approximately 160 kDa. It is expressed widely in the brain where it plays a critical role in the connection between neurons. The NRXN3 protein helps establish and maintain synaptic connections facilitating communication in the nervous system. Different isoforms of NRXN3 generated through alternative splicing allow for diverse synaptic functions.
Biological function summary

The protein contributes to the formation of complex structures in synapses. NRXN3 interacts with neuroligins and other postsynaptic proteins forming a bridge across the synaptic cleft. This interaction is essential for the alignment and stabilization of pre- and postsynaptic formations influencing synaptic transmission. The NRXN3 complex enables specific synaptic architecture affecting both excitatory and inhibitory synapses.

Pathways

NRXN3 plays a role in key neural signaling routes. It participates in the synaptic formation and plasticity pathways being important for both synaptogenesis and synaptic maintenance. NRXN3 shares pathway interactions with proteins such as neuroligin and dystroglycan. This alignment is important for regulating synapse stabilization and may influence the release of neurotransmitters across synaptic junctions.

NRXN3 is linked to neurological conditions including autism spectrum disorders (ASD) and schizophrenia. Genetic variations in NRXN3 have been associated with synaptic dysfunction that can contribute to these conditions. It connects with proteins such as NRXN1 and neuroligins which are also implicated in similar neuropsychiatric disorders. Understanding NRXN3's involvement could aid in developing targeted therapies for these complex diseases.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity).
See full target information NRXN3
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell discovery 10:11 PubMed38291322

2024

Structural insights into the specific recognition of mitochondrial ribosome-binding factor hsRBFA and 12 S rRNA by methyltransferase METTL15.

Applications

Unspecified application

Species

Unspecified reactive species

Mengqi Lv,Wanwan Zhou,Yijie Hao,Fudong Li,Huafeng Zhang,Xuebiao Yao,Yunyu Shi,Liang Zhang
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com